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Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics 利用多性状遗传学识别慢性阻塞性肺疾病亚型 Ziyatdinov, Andrey; Hobbs, Brian D.; Kanaan-Izquierdo, Samir; Moll, Matthew; Sakornsakolpat, Phuwanat; Shrine, Nick; Chen, Jing; Song, Kijoung; Bowler, Russell P.; Castaldi, Peter J.; Tobin, Martin D.; Kraft, Peter; Silverman, Edwin K.; Julienne, Hanna; Cho, Michael H.; Aschard, Hugues 分享 收藏
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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (vol 51, pg 481, 2019) 跨多个祖先的肺功能突出通路和慢性阻塞性肺疾病关联的新遗传信号 (第51卷，481页，2019) Shrine, Nick; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung; Sakornsakolpat, Phuwanat; Li, Xingnan; Boxall, Ruth; Reeve, Nicola F.; Obeidat, Ma'en; Zhao, Jing Hua; Wielscher, Matthias; Weiss, Stefan; Kentistou, Katherine A.; Cook, James P.; Sun, Benjamin B.; Zhou, Jian; Hui, Jennie; Karrasch, Stefan; Imboden, Medea; Harris, Sarah E.; Marten, Jonathan; Enroth, Stefan; Kerr, Shona M.; Surakka, Ida; Vitart, Veronique; Lehtimaeki, Terho; Allen, Richard J.; Bakke, Per S.; Beaty, Terri H.; Bleecker, Eugene R.; Bosse, Yohan; Brandsma, Corry-Anke; Chen, Zhengming; Crapo, James D.; Danesh, John; DeMeo, Dawn L.; Dudbridge, Frank; Ewert, Ralf; Gieger, Christian; Gulsvik, Amund; Hansell, Anna L.; Hao, Ke; Hoffman, Joshua D.; Hokanson, John E.; Homuth, Georg; Joshi, Peter K.; Joubert, Philippe; Langenberg, Claudia; Li, Xuan; Li, Liming; Lin, Kuang; Lind, Lars; Locantore, Nicholas; Luan, Jian'an; Mahajan, Anubha; Maranville, Joseph C.; Murray, Alison; Nickle, David C.; Packer, Richard; Parker, Margaret M.; Paynton, Megan L.; Porteous, David J.; Prokopenko, Dmitry; Qiao, Dandi; Rawal, Rajesh; Runz, Heiko; Sayers, Ian; Sin, Don D.; Smith, Blair H.; Artigas, Maria Soler; Sparrow, David; Tal-Singer, Ruth; Timmers, Paul R. H. J.; Van den Berge, Maarten; Whittaker, John C.; Woodruff, Prescott G.; Yerges-Armstrong, Laura M.; Troyanskaya, Olga G.; Raitakari, Olli T.; Kaehoenen, Mika; Polasek, Ozren; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J.; Probst-Hensch, Nicole M.; Schulz, Holger; James, Alan L.; Wilson, James F.; Stubbe, Beate; Zeggini, Eleftheria; Jarvelin, Marjo-Riitta; Wareham, Nick; Silverman, Edwin K.; Hayward, Caroline; Morris, Andrew P.; Butterworth, Adam S.; Scott, Robert A.; Walters, Robin G.; Meyers, Deborah A.; Cho, Michael H.; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.; Wain, Louise V. 分享 收藏
Genome-wide association study of preserved ratio impaired spirometry (PRISm) 保留比率受损肺活量测定法 (PRISm) 的全基因组关联研究 Higbee, Daniel H.; Lirio, Alvin; Hamilton, Fergus; Granell, Raquel; Wyss, Annah B.; London, Stephanie J.; Bartz, Traci M.; Gharib, Sina A.; Cho, Michael H.; Wan, Emily; Silverman, Edwin; Crapo, James D.; Lominchar, Jesus V. T.; Hansen, Torben; Grarup, Niels; Dantoft, Thomas; Karhus, Line; Linneberg, Allan; O'Connor, George T.; Dupuis, Josee; Xu, Hanfie; De Vries, Maaike M.; Hu, Xiaowei; Rich, Stephen S.; Barr, R. Graham; Manichaikul, Ani; Wijnant, Sara R. A.; Brusselle, Guy G.; Lahousse, Lies; Li, Xuan; Cordero, Ana I. Hernandez; Obeidat, Ma'en; Sin, Don D.; Harris, Sarah E.; Redmond, Paul; Taylor, Adele M.; Cox, Simon R.; Williams, Alexander T.; Shrine, Nick; John, Catherine; Guyatt, Anna L.; Hall, Ian P.; Smith, George Davey; Tobin, Martin D.; Dodd, James W. 分享 收藏
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (vol 55, pg 410, 2023) 多血统全基因组关联分析可改善影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率 (第55卷，410页，2023) Shrine, Nick; Izquierdo, Abril G.; Chen, Jing; Packer, Richard; Hall, Robert J.; Guyatt, Anna L.; Batini, Chiara; Thompson, Rebecca J.; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D.; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per; Fawcett, Katherine A.; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wijnant, Sara R. A.; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G.; Manichaikul, Ani; Oelsner, Elizabeth C.; Rich, Stephen S.; Barr, R. Graham; Kerr, Shona M.; Vitart, Veronique; Brown, Michael R.; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M.; Gharib, Sina A.; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E.; Meyers, Deborah A.; Bleecker, Eugene R.; Gabriel, Stacey B.; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin F.; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H.; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L.; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T.; Thareja, Gaurav; Albagha, Omar M. E.; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O.; Hiemstra, Pieter S.; Slats, Annelies M.; Mullin, Benjamin H.; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T.; Wyss, Annah B.; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A.; Joshi, Peter K.; Timmers, Paul R. H. J.; Williams, Alexander T.; Free, Robert C.; Wang, Xueyang; Morrison, John L.; Gilliland, Frank D.; Chen, Zhanghua; Wang, Carol A.; Foong, Rachel E.; Harris, Sarah E.; Taylor, Adele; Redmond, Paul; Cook, James P.; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimaki, Terho; Raitakari, Olli T.; Kaprio, Jaakko; Rantanen, Taina; Pietilainen, Kirsi H.; Cox, Simon R.; Pennell, Craig E.; Hall, Graham L.; Gauderman, W. James; Brightling, Chris; Wilson, James F.; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O.; Timpson, Nicholas J.; Zeggini, Eleftheria; Dupuis, Josee; Hayward, Caroline; Brumpton, Ben; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C.; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L.; Dudbridge, Frank; Silverman, Edwin K.; Strachan, David P.; Walters, Robin G.; Morris, Andrew P.; London, Stephanie J.; Cho, Michael H.; Wain, Louise V.; Hall, Ian P.; Tobin, Martin D. 分享 收藏
Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease 遗传性非酒精性脂肪肝病的罕见MTTP变异的鉴定和表征 Grove, Jane I.; Lo, Peggy C. K.; Shrine, Nick; Barwell, Julian; V. Wain, Louise; Tobin, Martin D.; Salter, Andrew M.; Borkar, Aditi N.; Cuevas-Ocana, Sara; Bennett, Neil; John, Catherine; Ntalla, Ioanna; Jones, Gabriela E.; Neal, Christopher P.; Thomas, Mervyn G.; Kuht, Helen; Gupta, Pankaj; Vemala, Vishwaraj M.; Grant, Allister; Adewoye, Adeolu B.; Shenoy, Kotacherry T.; Balakumaran, Leena K.; Hollox, Edward J.; Hannan, Nicholas R. F.; Aithal, Guruprasad P. 分享 收藏
Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection 慢性痰液产生的全基因组关联研究涉及参与粘液产生和感染的基因座 Packer, Richard J.; Shrine, Nick; Hall, Robert; Melbourne, Carl A.; Thompson, Rebecca; Williams, Alex T.; Paynton, Megan L.; Guyatt, Anna L.; Allen, Richard J.; Lee, Paul H.; John, Catherine; Campbell, Archie; Hayward, Caroline; de Vries, Maaike; Vonk, Judith M.; Davitte, Jonathan; Hessel, Edith; Michalovich, David; Betts, Joanna C.; Sayers, Ian; Yeo, Astrid; Hall, Ian P.; Tobin, Martin D.; Wain, Louise, V 分享 收藏
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 多血统全基因组关联分析可改善影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率 Shrine, Nick; Izquierdo, Abril G.; Chen, Jing; Packer, Richard; Hall, Robert J.; Guyatt, Anna L.; Batini, Chiara; Thompson, Rebecca J.; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D.; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per; Fawcett, Katherine A.; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wijnant, Sara R. A.; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G.; Manichaikul, Ani; Oelsner, Elizabeth C.; Rich, Stephen S.; Barr, R. Graham; Kerr, Shona M.; Vitart, Veronique; Brown, Michael R.; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M.; Gharib, Sina A.; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E.; Meyers, Deborah A.; Bleecker, Eugene R.; Gabriel, Stacey B.; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin F.; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H.; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L.; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T.; Thareja, Gaurav; Albagha, Omar M. E.; Ismail, Said I.; Al-Muftah, Wadha; Badji, Radja; Mbarek, Hamdi; Darwish, Dima; Fadl, Tasnim; Yasin, Heba; Ennaifar, Maryem; Abdellatif, Rania; Alkuwari, Fatima; Alvi, Muhammad; Al-Sarraj, Yasser; Saad, Chadi; Althani, Asmaa; Fethnou, Eleni; Qafoud, Fatima; Alkhayat, Eiman; Afifi, Nahla; Tomei, Sara; Liu, Wei; Lorenz, Stephan; Syed, Najeeb; Almabrazi, Hakeem; Vempalli, Fazulur Rehaman; Temanni, Ramzi; Abu Saqri, Tariq; Khatib, Mohammedhusen; Hamza, Mehshad; Abu Zaid, Tariq; El Khouly, Ahmed; Pathare, Tushar; Poolat, Shafeeq; Al-Ali, Rashid; Al-Khodor, Souhaila; Alshafai, Mashael; Badii, Ramin; Chouchane, Lotfi; Estivill, Xavier; Fakhro, Khalid; Mokrab, Younes; Puthen, Jithesh, V; Tatari, Zohreh; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O.; Hiemstra, Pieter S.; Slats, Annelies M.; Mullin, Benjamin H.; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T.; Wyss, Annah B.; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A.; Joshi, Peter K.; Timmers, Paul R. H. J.; Williams, Alexander T.; Free, Robert C.; Wang, Xueyang; Morrison, John L.; Gilliland, Frank D.; Chen, Zhanghua; Wang, Carol A.; Foong, Rachel E.; Harris, Sarah E.; Taylor, Adele; Redmond, Paul; Cook, James P.; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimaki, Terho; Raitakari, Olli T.; Kaprio, Jaakko; Rantanen, Taina; Pietilainen, Kirsi H.; Cox, Simon R.; Pennell, Craig E.; Hall, Graham L.; Gauderman, W. James; Brightling, Chris; Wilson, James F.; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O.; Timpson, Nicholas J.; Zeggini, Eleftheria; Dupuis, Josee; Hayward, Caroline; Brumpton, Ben; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C.; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L.; Dudbridge, Frank; Silverman, Edwin K.; Strachan, David P.; Walters, Robin G.; Morris, Andrew P.; London, Stephanie J.; Cho, Michael H.; Wain, Louise, V; Hall, Ian P.; Tobin, Martin 分享 收藏
Multi-ancestry genetic risk score for lung function from meta-analysis of genome-wide association studies in 580,869 individuals from five ancestry groups Shrine, N.; Izqueirdo, A.; Chen, J.; Guyatt, A. L.; Packer, R.; Batini, C.; Pozarickij, A.; Walters, R. G.; London, S.; Morris, A. P.; Wain, L. V.; Hall, I. P.; Tobin, M. D. 分享 收藏
Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK Piga, Noemi-Nicole; Boua, Palwende Romuald; Soremekun, Chisom; Shrine, Nick; Coley, Kayesha; Brandenburg, Jean-Tristan; Tobin, Martin D.; Ramsay, Michele; Fatumo, Segun; Choudhury, Ananyo; Batini, Chiara 分享 收藏
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease Guyatt, Anna; John, Catherine; Williams, Alexander T.; Shrine, Nick; Reeve, Nicola F.; Sayers, Ian; Hall, Ian; Wain, Louise, V; Sheehan, Nuala; Dudbridge, Frank; Tobin, Martin D. 分享 收藏
Genetic Associations and Architecture of Asthma-COPD Overlap John, Catherine; Guyatt, Anna L.; Shrine, Nick; Packer, Richard; Olafsdottir, Thorunn A.; Liu, Jiangyuan; Hayden, Lystra P.; Chu, Su H.; Koskela, Jukka T.; Luan, Jian'an; Li, Xingnan; Terzikhan, Natalie; Xu, Hanfei; Bartz, Traci M.; Petersen, Hans; Leng, Shuguang; Belinsky, Steven A.; Cepelis, Aivaras; Cordero, Ana I. Hernandez; Obeidat, Ma'en; Thorleifsson, Gudmar; Meyers, Deborah A.; Bleecker, Eugene R.; Sakoda, Lori C.; Iribarren, Carlos; Tesfaigzi, Yohannes; Gharib, Sina A.; Dupuis, Josee; Brusselle, Guy; Lahousse, Lies; Ortega, Victor E.; Jonsdottir, Ingileif; Sin, Don D.; Bosse, Yohan; van den Berge, Maarten; Nickle, David; Quint, Jennifer K.; Sayers, Ian; Hall, Ian P.; Langenberg, Claudia; Ripatti, Samuli; Laitinen, Tarja; Wu, Ann C.; Lasky-Su, Jessica; Bakke, Per; Gulsvik, Amund; Hersh, Craig P.; Hayward, Caroline; Langhammer, Arnulf; Brumpton, Ben; Stefansson, Kari; Cho, Michael H.; Wain, Louise, V; Tobin, Martin D. 分享 收藏
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Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function 肺功能中的罕见和低频外显子变异和吸烟基因相互作用 Yang, Tianzhong; Jackson, Victoria E.; Smith, Albert, V; Chen, Han; Bartz, Traci M.; Sitlani, Colleen M.; Psaty, Bruce M.; Gharib, Sina A.; O'Connor, George T.; Dupuis, Josee; Xu, Jiayi; Lohman, Kurt; Liu, Yongmei; Kritchevsky, Stephen B.; Cassano, Patricia A.; Flexeder, Claudia; Gieger, Christian; Karrasch, Stefan; Peters, Annette; Schulz, Holger; Harris, Sarah E.; Starr, John M.; Deary, Ian J.; Manichaikul, Ani; Oelsner, Elizabeth C.; Barr, R. G.; Taylor, Kent D.; Rich, Stephen S.; Bonten, Tobias N.; Mook-Kanamori, Dennis O.; Noordam, Raymond; Li-Gao, Ruifang; Jarvelin, Marjo-Riitta; Wielscher, Matthias; Terzikhan, Natalie; Lahousse, Lies; Brusselle, Guy; Weiss, Stefan; Ewert, Ralf; Glaeser, Sven; Homuth, Georg; Shrine, Nick; Hall, Ian P.; Tobin, Martin; London, Stephanie J.; Wei, Peng; Morrison, Alanna C. 分享 收藏
Familial hypereosinophilia associated with eosinophilic gastrointestinal symptoms in individuals with a missense mutation in CKLF-like MARVEL transmembrane domain containing 3 Wardlaw, Andrew J.; Barwell, Julian; Hitchman, Charles; Shrine, Nick; Bennett, Neil; Adewoye, Ade; Ozturk, Hasret; Ntereke, Tumisang; Wurm, Peter; Tobin, Martin; Gooptu, Bibek; Hollox, Ed; Wain, Louise V. 分享 收藏
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts Fabbri, Chiara; Hagenaars, Saskia P.; John, Catherine; Williams, Alexander T.; Shrine, Nick; Moles, Louise; Hanscombe, Ken B.; Serretti, Alessandro; Shepherd, David J.; Free, Robert C.; Wain, Louise, V; Tobin, Martin D.; Lewis, Cathryn M. 分享 收藏
Phenotypic and functional translation of IL33 genetics in asthma Ketelaar, Maria E.; Portelli, Michael A.; Dijk, F. Nicole; Shrine, Nick; Faiz, Alen; Vermeulen, Cornelis J.; Xu, Cheng J.; Hankinson, Jenny; Bhaker, Sangita; Henry, Amanda P.; Billington, Charlote K.; Shaw, Dominick E.; Johnson, Simon R.; Benest, Andrew, V; Pang, Vincent; Bates, David O.; Pogson, Z. E. K.; Fogarty, Andrew; McKeever, Tricia M.; Singapuri, Amisha; Heaney, Liam G.; Mansur, Adel H.; Chaudhuri, Rekha; Thomson, Neil C.; Holloway, John W.; Lockett, Gabrielle A.; Howarth, Peter H.; Niven, Robert; Simpson, Angela; Tobin, Martin D.; Hall, Ian P.; Wain, Louise, V; Blakey, John D.; Brightling, Christopher E.; Obeidat, Ma'en; Sin, Don D.; Nickle, David C.; Bosse, Yohan; Vonk, Judith M.; van den Berge, Maarten; Koppelman, Gerard H.; Sayers, Ian; Nawijn, Martijn C. 分享 收藏
A genome-wide association study of asthma-COPD overlap syndrome (ACOS) John, Catherine; Guyatt, Anna L.; Shrine, Nick; Olafsdottir, Thorunn; Liu, Jiangyuan; Hayden, Lystra; Chu, Su H.; Koskela, Jukka; Luan, Jian'An; Li, Xingnan; Terzikhan, Natalie; Xu, Hanfei; Bartz, Traci M.; Petersen, Hans; Leng, Shuguang; Thorleifsson, Gudmar; Meyers, Deborah A.; Bleecker, Eugene R.; Sakoda, Lori C.; Iribarren, Carlos; Tesfaigzi, Yohannes; Gharib, Sina A.; Dupuis, Josee; Lahousse, Lies; Ortega, Victor E.; Stefansson, Kari; Sayers, Ian; Hall, Ian P.; Langenberg, Claudia; Ripatti, Samuli; Laitinen, Tarja; Wu, Ann C.; Lasky-Su, Jessica; Hayward, Caroline; Brumpton, Ben; Langhammer, Arnulf; Jonsdottir, Ingileif; Cho, Michael H.; Wain, Louise, V; Tobin, Martin D. 分享 收藏
Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease Kim, Woori; Prokopenko, Dmitry; Sakornsakolpat, Phuwanat; Hobbs, Brian D.; Lutz, Sharon M.; Hokanson, John E.; Wain, Louise, V; Melbourne, Carl A.; Shrine, Nick; Tobin, Martin D.; Silverman, Edwin K.; Cho, Michael H.; Beaty, Terri H. 分享 收藏
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