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Tomoya Isobe

University of Cambridge
H指数:15
被引数:1,100

个人简介

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工作经历

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荣誉奖项

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Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis

代谢物诱导的DNA损伤驱动随机干细胞丢失和克隆性造血

Cell Stem Cell
IF20.4
2026-03-230
OAAI
Ashley N. Kamimae-Lanning; Jill M. Brown; Matthias Günther; Franziska Esau; Holly Russell; Lise Larcher; Frédéric Langevin; Tomoya Isobe; Nicola K. Wilson; Felix A. Dingler; Rebecca L. Cordell; Meng Wang; Christopher L. Millington; Nina Claudino; Ewa Gogola; Matthew Nicholls; Verena Körber; Berthold Göttgens; Marella F.T.R. de Bruijn; Juan I. Garaycoechea
Comprehensive Molecular and Functional Analysis of NUTM1-Rearranged Leukemia

NUTM1易位白血病的综合分子与功能分析

Blood
IF23.1
2025-12-310
PRE
Koutarou Nishimura; Tomoya Isobe; Tsukasa Shigehiro; Masaki Nomura; Weijia Zang; Muran Xiao; Wenjuan Liao; Yui Koike; Akira Nishimura; Aiko Sato-Otsubo; Hiromi Yamazaki; Hiromi Ito; Shinri Okada; Naomi Matsumoto; Wataru Saika; Yifan Zhang; Yumi Aoyama; Chihiro Hasegawa; Takaya Yamasaki; Yasuo Kubota
Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell–type chronic active EBV infection

多组学分析揭示了高风险NK细胞型慢性活动性EBV感染中的遗传和表观遗传特征

Blood
IF23.1
2025-08-050
PREAI
Ryo Akazawa; Takashi Mikami; Masaki Yamada; Itaru Kato; Hirohito Kubota; Satoshi Saida; Yoshinori Uchihara; Yuriko Ishikawa; Tatsuya Kamitori; Keiji Tasaka; Kiyotaka Isobe; Tomoya Isobe; Kazushi Izawa; Katsutsugu Umeda; Hidefumi Hiramatsu; Keita Jinnouchi; Masahiro Hirata; Masakazu Fujimoto; Tomoo Daifu; Hiroo Ueno; Seishiro Nodomi; Machiko Sawada; Hisanori Fujino; Katsuyoshi Koh; Mitsuteru Hiwatari; Motohiro Kato; Hiroaki Goto; Ikumi Katano; Ryoji Ito; Mamoru Ito; Nobuyuki Kakiuchi; Masahiro M. Nakagawa; Yuichi Shiraishi; Yoshitaka Honda; Hiroyuki Yoshitomi; Hideki Ueno; Maho Sato; Satoru Miyano; Hironori Haga; Akihisa Sawada; Ken-Ichi Imadome; Seishi Ogawa; Junko Takita
Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity
cardiovascular research
IF10.8
2024-12-090
PRE
Sato, Naru; Goyama, Susumu; Chang, Yu-Hsuan; Miyawaki, Masashi; Fujino, Takeshi; Koide, Shuhei; Denda, Tamami; Liu, Xiaoxiao; Ueda, Koji; Yamamoto, Keita; Asada, Shuhei; Takeda, Reina; Yonezawa, Taishi; Tanaka, Yosuke; Honda, Hiroaki; Ota, Yasunori; Shibata, Takuma; Sekiya, Motohiro; Isobe, Tomoya; Lamagna, Chrystelle; Masuda, Esteban; Iwama, Atsushi; Shimano, Hitoshi; Inoue, Jun-ichiro; Miyake, Kensuke; Kitamura, Toshio
Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type

骨髓/自然杀伤 (NK) 细胞前体急性白血病是一种独特的白血病类型

SCIENCE ADVANCES
IF12.5
2023-12-152
OAAI
Nishimura, Akira; Yokoyama, Kazuaki; Naruto, Takuya; Yamagishi, Chika; Imamura, Toshihiko; Nakazono, Hiroto; Kimura, Shunsuke; Ito, Mieko; Sagisaka, Maiko; Tanaka, Yukie; Piao, Jinhua; Namikawa, Yui; Yanagimachi, Masakatsu; Isoda, Takeshi; Kanai, Akinori; Matsui, Hirotaka; Isobe, Tomoya; Sato-Otsubo, Aiko; Higuchi, Naoko; Takada, Akiko; Okuno, Haruna; Saito, Shoji; Karakawa, Shuhei; Kobayashi, Shogo; Hasegawa, Daisuke; Fujisaki, Hiroyuki; Hasegawa, Daiichiro; Koike, Kazutoshi; Koike, Takashi; Rai, Shinya; Umeda, Katsutsugu; Sano, Hideki; Sekinaka, Yujin; Ogawa, Atsushi; Kinoshita, Akitoshi; Shiba, Norio; Miki, Mizuka; Kimura, Fumihiko; Nakayama, Hideki; Nakazawa, Yozo; Taga, Takashi; Taki, Tomohiko; Adachi, Souichi; Manabe, Atsushi; Koh, Katsuyoshi; Ishida, Yasushi; Takita, Junko; Ishikawa, Fumihiko; Goto, Hiroaki; Morio, Tomohiro; Mizutani, Shuki; Tojo, Arinobu; Takagi, Masatoshi
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes
CELL GENOMICS
IF9
2023-12-011
OAAI
Isobe, Tomoya; Kucinski, Iwo; Barile, Melania; Wang, Xiaonan; Hannah, Rebecca; Bastos, Hugo P.; Chabra, Shirom; Vijayabaskar, M. S.; Sturgess, Katherine H. M.; Williams, Matthew J.; Giotopoulos, George; Marando, Ludovica; Li, Juan; Rak, Justyna; Gozdecka, Malgorzata; Prins, Daniel; Shepherd, Mairi S.; Watcham, Sam; Green, Anthony R.; Kent, David G.; Vassiliou, George S.; Huntly, Brian J. P.; Wilson, Nicola K.; Gottgens, Berthold
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment

有丝分裂扰动是地西他滨治疗髓系肿瘤的关键作用机制

CELL REPORTS
IF6.9
2023-09-014
OA
Yabushita, Tomohiro; Chinen, Takumi; Nishiyama, Atsuya; Asada, Shuhei; Shimura, Ruka; Isobe, Tomoya; Yamamoto, Keita; Sato, Naru; Enomoto, Yutaka; Tanaka, Yosuke; Fukuyama, Tomofusa; Satoh, Hitoshi; Kato, Keiko; Saitoh, Kaori; Ishikawa, Takamasa; Soga, Tomoyoshi; Nannya, Yasuhito; Fukagawa, Tatsuo; Nakanishi, Makoto; Kitagawa, Daiju; Kitamura, Toshio; Goyama, Susumu
Identification of the ultrahigh-risk subgroup in neuroblastoma cases through DNA methylation analysis and its treatment exploiting cancer metabolism
ONCOGENE
IF7.3
2022-11-017
OAAI
Watanabe, Kentaro; Kimura, Shunsuke; Seki, Masafumi; Isobe, Tomoya; Kubota, Yasuo; Sekiguchi, Masahiro; Sato-Otsubo, Aiko; Hiwatari, Mitsuteru; Kato, Motohiro; Oka, Akira; Koh, Katsuyoshi; Sato, Yusuke; Tanaka, Hiroko; Miyano, Satoru; Kawai, Tomoko; Hata, Kenichiro; Ueno, Hiroo; Nannya, Yasuhito; Suzuki, Hiromichi; Yoshida, Kenichi; Fujii, Yoichi; Nagae, Genta; Aburatani, Hiroyuki; Ogawa, Seishi; Takita, Junko
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
NATURE COMMUNICATIONS
IF15.7
2022-08-3014
OAAI
Isobe, Tomoya; Takagi, Masatoshi; Sato-Otsubo, Aiko; Nishimura, Akira; Nagae, Genta; Yamagishi, Chika; Tamura, Moe; Tanaka, Yosuke; Asada, Shuhei; Takeda, Reina; Tsuchiya, Akiho; Wang, Xiaonan; Yoshida, Kenichi; Nannya, Yasuhito; Ueno, Hiroo; Akazawa, Ryo; Kato, Itaru; Mikami, Takashi; Watanabe, Kentaro; Sekiguchi, Masahiro; Seki, Masafumi; Kimura, Shunsuke; Hiwatari, Mitsuteru; Kato, Motohiro; Fukuda, Shiro; Tatsuno, Kenji; Tsutsumi, Shuichi; Kanai, Akinori; Inaba, Toshiya; Shiozawa, Yusuke; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Kotecha, Rishi S.; Cruickshank, Mark N.; Ishikawa, Fumihiko; Morio, Tomohiro; Eguchi, Mariko; Deguchi, Takao; Kiyokawa, Nobutaka; Arakawa, Yuki; Koh, Katsuyoshi; Aoki, Yuki; Ishihara, Takashi; Tomizawa, Daisuke; Miyamura, Takako; Ishii, Eiichi; Mizutani, Shuki; Wilson, Nicola K.; Gottgens, Berthold; Miyano, Satoru; Kitamura, Toshio; Goyama, Susumu; Yokoyama, Akihiko; Aburatani, Hiroyuki; Ogawa, Seishi; Takita, Junko
Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia
BLOOD ADVANCES
IF7.1
2020-10-2336
OAAI
Ueno, Hiroo; Yoshida, Kenichi; Shiozawa, Yusuke; Nannya, Yasuhito; Iijima-Yamashita, Yuka; Kiyokawa, Nobutaka; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Isobe, Tomoya; Seki, Masafumi; Kimura, Shunsuke; Makishima, Hideki; Nakagawa, Masahiro M.; Kakiuchi, Nobuyuki; Kataoka, Keisuke; Yoshizato, Tetsuichi; Nishijima, Dai; Deguchi, Takao; Ohki, Kentaro; Sato, Atsushi; Takahashi, Hiroyuki; Hashii, Yoshiko; Tokimasa, Sadao; Hara, Junichi; Kosaka, Yoshiyuki; Kato, Koji; Inukai, Takeshi; Takita, Junko; Imamura, Toshihiko; Miyano, Satoru; Manabe, Atsushi; Horibe, Keizo; Ogawa, Seishi; Sanada, Masashi
Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets
COMMUNICATIONS BIOLOGY
IF5.1
2020-09-3010
OAAI
Kubota, Yasuo; Seki, Masafumi; Kawai, Tomoko; Isobe, Tomoya; Yoshida, Misa; Sekiguchi, Masahiro; Kimura, Shunsuke; Watanabe, Kentaro; Sato-Otsubo, Aiko; Yoshida, Kenichi; Suzuki, Hiromichi; Kataoka, Keisuke; Fujii, Yoichi; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Hiwatari, Mitsuteru; Oka, Akira; Hayashi, Yasuhide; Miyano, Satoru; Ogawa, Seishi; Hata, Kenichiro; Tanaka, Yukichi; Takita, Junko
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets
NPJ PRECISION ONCOLOGY
IF8
2020-07-0734
OAAI
Sekiguchi, Masahiro; Seki, Masafumi; Kawai, Tomoko; Yoshida, Kenichi; Yoshida, Misa; Isobe, Tomoya; Hoshino, Noriko; Shirai, Ryota; Tanaka, Mio; Souzaki, Ryota; Watanabe, Kentaro; Arakawa, Yuki; Nannya, Yasuhito; Suzuki, Hiromichi; Fujii, Yoichi; Kataoka, Keisuke; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Shimamura, Teppei; Sato, Yusuke; Sato-Otsubo, Aiko; Kimura, Shunsuke; Kubota, Yasuo; Hiwatari, Mitsuteru; Koh, Katsuyoshi; Hayashi, Yasuhide; Kanamori, Yutaka; Kasahara, Mureo; Kohashi, Kenichi; Kato, Motohiro; Yoshioka, Takako; Matsumoto, Kimikazu; Oka, Akira; Taguchi, Tomoaki; Sanada, Masashi; Tanaka, Yukichi; Miyano, Satoru; Hata, Kenichiro; Ogawa, Seishi; Takita, Junko
DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes
LEUKEMIA
IF13.4
2019-11-1514
PREAI
Kimura, Shunsuke; Seki, Masafumi; Kawai, Tomoko; Goto, Hiroaki; Yoshida, Kenichi; Isobe, Tomoya; Sekiguchi, Masahiro; Watanabe, Kentaro; Kubota, Yasuo; Nannya, Yasuhito; Ueno, Hiroo; Shiozawa, Yusuke; Suzuki, Hiromichi; Shiraishi, Yuichi; Ohki, Kentaro; Kato, Motohiro; Koh, Katsuyoshi; Kobayashi, Ryoji; Deguchi, Takao; Hashii, Yoshiko; Imamura, Toshihiko; Sato, Atsushi; Kiyokawa, Nobutaka; Manabe, Atsushi; Sanada, Masashi; Mansour, Marc R.; Ohara, Akira; Horibe, Keizo; Kobayashi, Masao; Oka, Akira; Hayashi, Yasuhide; Miyano, Satoru; Hata, Kenichiro; Ogawa, Seishi; Takita, Junko
Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma
CANCER RESEARCH
IF16.6
2018-02-1426
OAAI
Isobe, Tomoya; Seki, Masafumi; Yoshida, Kenichi; Sekiguchi, Masahiro; Shiozawa, Yusuke; Shiraishi, Yuichi; Kimura, Shunsuke; Yoshida, Misa; Inoue, Yoshikage; Yokoyama, Akira; Kakiuchi, Nobuyuki; Suzuki, Hiromichi; Kataoka, Keisuke; Sato, Yusuke; Kawai, Tomoko; Chiba, Kenichi; Tanaka, Hiroko; Shimamura, Teppei; Kato, Motohiro; Iguchi, Akihiro; Hama, Asahito; Taguchi, Tomoaki; Akiyama, Masaharu; Fujimura, Junya; Inoue, Akiko; Ito, Tsuyoshi; Deguchi, Takao; Kiyotani, Chikako; Iehara, Tomoko; Hosoi, Hajime; Oka, Akira; Sanada, Masashi; Tanaka, Yukichi; Hata, Kenichiro; Miyano, Satoru; Ogawa, Seishi; Takita, Junko
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
NATURE GENETICS
IF31.8
2017-07-03106
PREAI
Seki, Masafumi; Kimura, Shunsuke; Isobe, Tomoya; Yoshida, Kenichi; Ueno, Hiroo; Nakajima-Takagi, Yaeko; Wang, Changshan; Lin, Lin; Kon, Ayana; Suzuki, Hiromichi; Shiozawa, Yusuke; Kataoka, Keisuke; Fujii, Yoichi; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Shimamura, Teppei; Masuda, Kyoko; Kawamoto, Hiroshi; Ohki, Kentaro; Kato, Motohiro; Arakawa, Yuki; Koh, Katsuyoshi; Hanada, Ryoji; Moritake, Hiroshi; Akiyama, Masaharu; Kobayashi, Ryoji; Deguchi, Takao; Hashii, Yoshiko; Imamura, Toshihiko; Sato, Atsushi; Kiyokawa, Nobutaka; Oka, Akira; Hayashi, Yasuhide; Takagi, Masatoshi; Manabe, Atsushi; Ohara, Akira; Horibe, Keizo; Sanada, Masashi; Iwama, Atsushi; Mano, Hiroyuki; Miyano, Satoru; Ogawa, Seishi; Takita, Junko

研究方向

暂未获取到该数据
J
Junko Takita
H 指数:43论文数:506被引数:8,988
S
Seishi Ogawa
H 指数:113论文数:1,493被引数:5.5万
S
Satoru Miyano
H 指数:113论文数:1,593被引数:6.9万
S
Shunsuke Kimura
H 指数:23论文数:139被引数:1,676
Y
Yuichi Shiraishi
H 指数:83论文数:695被引数:3.6万
K
Katsuyoshi Koh
H 指数:38论文数:405被引数:5,973
K
Kenichi Yoshida
H 指数:87论文数:898被引数:3.3万
M
Masafumi Seki
H 指数:21论文数:116被引数:1,492
H
Hiroo Ueno
H 指数:43论文数:160被引数:6,969
M
Motohiro Kato
H 指数:61论文数:830被引数:1.4万