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A

Alejandra Tomás

imperial college london
H指数:35
被引数:4,179

个人简介

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荣誉奖项

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In vivo functional profiling and structural characterization of the human GLP1R A316T variant
Science Advances
IF12.5
2026-02-040
OA
Liliane El Eid; Yusman Manchanda; Gregory Austin; Kieran Deane-Alder; Roxana-Maria Rujan; Zamara Mariam; Affiong I. Oqua; Matthew J. Belousoff; Jorge Bernardino de la Serna; Kyle W. Sloop; Guy A. Rutter; Alex Montoya; Dominic J. Withers; Steven J. Millership; Karim Bouzakri; Ben Jones; Christopher A. Reynolds; Patrick M. Sexton; Denise Wootten; Giuseppe Deganutti; Alejandra Tomas
Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment

GIPR编码变异对血糖和体重的效应反映了表面表达差异和固有功能损害

Science Advances
IF12.5
2026-01-010
OA
Yusman Manchanda; Rofaida Desoki; Eugene J. Gardner; John R. B. Perry; David B. Wainscott; Cynthia Stutsman; Claudia Langenberg; Matthew P. Coghlan; Pallav Bhatnagar; Joseph D. Ho; Michael J. Yonkunas; Kyle W. Sloop; Ken K. Ong; Nicholas J. Wareham; Alejandra Tomás; Ben J. Jones
Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation

尽管受体定位存在差异，但β细胞中具有相反偏倚的GLP-1受体激动剂仍能产生空间弥散的cAMP信号传导。

Molecular Metabolism
IF6.6
2025-12-120
OAAI
Shiqian Chen; Carolina B. Lobato; Carissa Wong; Yusman Manchanda; Katrina Viloria; Iona Davies; Daniel B. Andersen; Julia Ast; Kyle W. Sloop; David J. Hodson; Johannes Broichhagen; Steve Bloom; Jens J. Holst; Tricia Tan; Alejandra Tomas; Ben Jones
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

GLP-1R在ERMCSs处与VAPB和SPHKAP相互作用，以调节β细胞线粒体重塑和功能。

Nature Communications
IF15.7
2025-12-100
OA
Gregory Austin; Affiong I. Oqua; Liliane El Eid; Mingli Zhu; Yusman Manchanda; Priyanka Peres; Helena Coyle; Yelyzaveta Poliakova; Zhanna Balkhiyarova; Karim Bouzakri; Alex Montoya; Dominic J. Withers; Michele Solimena; Ben Jones; Steven J. Millership; Steffen Burgold; David C. A. Gaboriau; Endre Majorovits; Evelyn Garlick; Maria Augusta do R. B. F. Lima; Inga Prokopenko; Jonathon Nixon-Abell; Andreas Müller; Alejandra Tomas
Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001

一种新型GLP-1R/GIPR双激动剂HISHS-2001的体外和体内结合动力学、偏向性、受体内化以及对胰岛素分泌的影响

diabetes obesity metabolism
IF0
2025-08-200
OAAI
Yusman Manchanda MSc; Ben Jones PhD; Gaelle Carrat PhD; Zenouska Ramchunder PhD; Piero Marchetti PhD; Isabelle Leclerc PhD; Rajamannar Thennati PhD; Vinod Burade PhD; Muthukumaran Natarajan MSc; Pradeep Shahi PhD; Alejandra Tomas PhD; Guy A. Rutter PhD
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

476,326个体中随机葡萄糖的gis提供了对糖尿病病理生理学，并发症和治疗分层的见解

NATURE GENETICS
IF31.8
2023-09-0720
OAAI
Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; Gonzalez, Karla Sofia Gutierrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Magi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, He; Evangelou, Evangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Mueller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Correa, Ivan R., Jr.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, Andre G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Ines; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njolstad, Inger; Wichmann, H. -Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josee; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga
Hypothalamic and brainstem glucose- dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding
JCI INSIGHT
IF6.1
2023-05-2224
OA
Adriaenssens, Alice; Broichhagen, Johannes; de Bray, Anne; Ast, Julia; Hasib, Annie; Jones, Ben; Tomas, Alejandra; Burgos, Natalie Figueredo; Woodward, Orla; Lewis, Jo; O'Flaherty, Elisabeth; El, Kimberley; Cui, Canqi; Harada, Norio; Inagaki, Nobuya; Campbell, Jonathan; Brierley, Daniel; Hodson, David J.; Samms, Ricardo; Gribble, Fiona; Reimann, Frank
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic 0 cells

雄性胰腺0细胞中增强胰高血糖素样肽-1促胰岛素作用的雄激素受体途径的结构

CELL REPORTS
IF6.9
2023-05-019
OAAI
Xu, Weiwei; Qadir, M. M. Fahd; Nasteska, Daniela; de Sa, Paula Mota; Gorvin, Caroline M.; Blandino-Rosano, Manuel; Evans, Charles R.; Ho, Thuong; Potapenko, Evgeniy; Veluthakal, Rajakrishnan; Ashford, Fiona B.; Bitsi, Stavroula; Fan, Jia; Bhondeley, Manika; Song, Kejing; Sure, Venkata N.; Sakamuri, Siva S. V. P.; Schiffer, Lina; Beatty, Wandy; Wyatt, Rachael; Frigo, Daniel E.; Liu, Xiaowen; Katakam, Prasad V.; Arlt, Wiebke; Buck, Jochen; Levin, Lonny R.; Hu, Tony; Kolls, Jay; Burant, Charles F.; Tomas, Alejandra; Merrins, Matthew J.; Thurmond, Debbie C.; Bernal-Mizrachi, Ernesto; Hodson, David J.; Mauvais-Jarvis, Franck

研究方向

暂未获取到该数据
B
Ben Jones
H 指数:37论文数:248被引数:4,508
G
Guy A. Rutter
H 指数:94论文数:666被引数:3.0万
Y
Yusman Manchanda
H 指数:7论文数:26被引数:255
D
David J. Hodson
H 指数:50论文数:248被引数:7,887
P
Philippe A. Halban
H 指数:73论文数:285被引数:1.8万
S
Stephen R. Bloom
H 指数:155论文数:1,419被引数:10.4万
I
Isabelle Leclerc
H 指数:33论文数:125被引数:4,091
T
Tricia Tan
H 指数:41论文数:367被引数:6,537
S
Stavroula Bitsi
H 指数:11论文数:26被引数:514
J
Johannes Broichhagen
H 指数:37论文数:274被引数:4,549