Ian E. Alexander - Publications, H-index & Citations

Ian E. Alexander

The University of Sydney and Sydney Children's Hospitals Network

51H指数

249论文数

1.4W被引数

收录论文 100

发表时间

Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk 体内鉴定人源和食蟹猴原代肝细胞中AAV载体整合位点及分析致癌风险

Molecular Therapy

IF12

2026-07-22

OAAI

Suzanne Scott; Claus V. Hallwirth; Natsuki Sasaki; Sharon C. Cunningham; Erhua Zhu; Neeta Khandekar; Eddy Kizana; Julien Baruteau; Paul Gissen; Dany P. Perocheau; Denis C. Bauer; Laurence O.W. Wilson; Leszek Lisowski; Ian E. Alexander

A novel fusion protein reduces kidney complement in experimental C3 glomerulopathy 一种新型融合蛋白可降低实验性C3肾小球病中的肾脏补体

Clinical and Experimental Immunology

IF3.8

2026-01-01

PREAI

Malik, Talat H.; Kwiatkowska, Karolina; Lomax-Browne, Hannah J.; Bottomley, Charlotte M.; Bright, Matthew; Tean, Zhang Sung; Akturk, Ahmet K.; Alexander, Ian E.; Logan, Grant J.; Pickering, Matthew C.

Exploration of the potential of genomic editing in the treatment of congenital adrenal hyperplasia 基因组编辑在先天性肾上腺皮质增生症治疗中潜力的探索

Frontiers in Endocrinology

IF4.6

2025-12-10

OAAI

Lara E. Graves; Sharntie Christina; Kathryn L. Mullany; Ian E. Alexander†; Henrik Falhammar†

Targeted editing of the 21-hydroxylase locus confers durable therapeutic effect in a murine model of congenital adrenal hyperplasia 靶向编辑21-羟化酶基因座在先天性肾上腺皮质增生症的小鼠模型中具有持久的治疗效果。

Molecular Therapy

IF12

2025-11-10

OAAI

Lara E. Graves; Lakshmy Viswanath; Eva B. van Dijk; Erhua Zhu; Sundar Koyyalamudi; Tiffany Wotton; Sebastian Rosser; Shubha Srinivasan; Samantha L. Ginn; Ian E. Alexander

Pancreatic Transdifferentiation of NOD Mouse Livers Prevented Development of Hyperglycemia NOD小鼠肝脏的胰腺转分化预防了高血糖的发展

Molecular Therapy

IF12

2025-10-11

PREAI

Alexandra L.G. Mahoney; Binhai Ren; Najah T. Nassif; Bronwyn A. O’Brien; Grant J. Logan; Catherine A. Gorrie; Ian E. Alexander; Ann M. Simpson

High-throughput evaluation of cardiac-specific promoters for adeno-associated virus mediated cardiac gene therapy 腺相关病毒介导的心脏基因治疗中高通量评价心脏特异性启动子

Gene Therapy

IF4.5

2025-07-19

OAAI

Dhanya Ravindran; Renuka Rao; Juan Mundisugih; Tracy Titus; Shinya Tsurusaki; Cindy Y. Kok; Fairooj N. Rashid; Sindhu Igoor; Yasuhito Kotake; Saurabh Kumar; James J. H. Chong; Ian E. Alexander; Leszek Lisowski; Eddy Kizana

Structural characterization of antibody-responses following Zolgensma treatment for AAV capsid engineering to expand patient cohorts Zolgensma治疗后抗体反应的结构表征及其对AAV衣壳工程化以扩大患者群体的研究

NATURE COMMUNICATIONS

IF15.7

2025-04-19

OAAI

Mietzsch, Mario; Hsi, Jane; Nelson, Austin R.; Khandekar, Neeta; Huang, Ann-Maree; Smith, Nicholas J. C.; Zachary, Jon; Potts, Lindsay; Farrar, Michelle A.; Chipman, Paul; Ghanem, Mohammad; Alexander, Ian E.; Logan, Grant J.; Huiskonen, Juha T.; McKenna, Robert

Stable transduction of the neonatal mouse liver using a hybrid rAAV/sleeping beauty transposon gene delivery system

JOURNAL OF GENE MEDICINE

IF2.2

2024-08-19

PREAI

Cunningham, Sharon C.; Zakas, Philip M.; Sasaki, Natsuki; van Dijk, Eva B.; Zhu, Erhua; Fu, Yanfang; Salomon, William E.; Citorik, Robert J.; Rubens, Jacob R.; Cotta-Ramusino, Cecilia; Querbes, William; Alexander, Ian E.

Gene therapy clinical trials worldwide to 2023-an update

JOURNAL OF GENE MEDICINE

IF2.2

2024-08-08

PREAI

Ginn, Samantha L.; Mandwie, Mawj; Alexander, Ian E.; Edelstein, Michael; Abedi, Mohammad R.

Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer's disease

JOURNAL OF NEUROINFLAMMATION

IF10.1

2024-03-27

OAAI

Ng, Roy Chun-Laam; Jian, Min; Ma, Oscar Ka-Fai; Xiang, Ariya Weiman; Bunting, Myriam; Kwan, Jason Shing-Cheong; Wong, Curtis Wai-Kin; Yick, Leung-Wah; Chung, Sookja Kim; Lam, Karen Siu-Ling; Alexander, Ian E.; Xu, Aimin; Chan, Koon-Ho

Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation 利用全人肝异位常温灌注进行临床前AAV载体评估

NATURE COMMUNICATIONS

IF15.7

2024-03-14

OAAI

Cabanes-Creus, Marti; Liao, Sophia H. Y.; Navarro, Renina Gale; Knight, Maddison; Nazareth, Deborah; Lau, Ngee-Soon; Ly, Mark; Zhu, Erhua; Roca-Pinilla, Ramon; Bugallo Delgado, Ricardo; Vicente, Ana F.; Baltazar, Grober; Westhaus, Adrian; Merjane, Jessica; Crawford, Michael; McCaughan, Geoffrey W.; Unzu, Carmen; Gonzalez-Aseguinolaza, Gloria; Alexander, Ian E.; Pulitano, Carlo; Lisowski, Leszek

Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice

MOLECULAR THERAPY

IF12

2024-03-01

OAAI

Drouyer, Matthieu; Merjane, Jessica; Nazareth, Deborah; Knight, Maddison; Scott, Suzanne; Liao, Sophia H. Y.; Ginn, Samantha L.; Zhu, Erhua; Alexander, Ian E.; Lisowski, Leszek

Generation of AAV9 Gene Therapy Capsid Variants Capable of Evading Neutralizing anti-AAV9 Antibodies derived from Patients Post-Zolgensma® Treatment

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Potts, Lindsay; Hsi, Jane; Mietzsch, Mario; Zachary, Jon; Nelson, Austin; Logan, Grant; Alexander, Ian; Huiskonen, Juha; Mckenna, Robert

Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy

MOLECULAR THERAPY

IF12

2023-07-01

OAAI

Logan, Grant J.; Mietzsch, Mario; Khandekar, Neeta; D'Silva, Arlene; Anderson, Daniel; Mandwie, Mawj; Hsi, Jane; Nelson, Austin R.; Chipman, Paul; Jackson, Jennifer; Schofield, Peter; Christ, Daniel; Goodnow, Christopher C.; Reed, Joanne H.; Farrar, Michelle A.; McKenna, Robert; Alexander, Ian E.

Future Directions for Adrenal Insufficiency: Cellular Transplantation and Genetic Therapies

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2023-01-06

PREAI

Graves, Lara E.; Torpy, David J.; Coates, P. Toby; Alexander, Ian E.; Bornstein, Stefan R.; Clarke, Brigette

Performance of Cardiotropic rAAV Vectors Is Dependent on Production Method

VIRUSES-BASEL

IF3.5

2022-07-26

OAAI

Rao, Renuka; Farraha, Melad; Logan, Grant J.; Igoor, Sindhu; Kok, Cindy Y.; Chong, James J. H.; Alexander, Ian E.; Kizana, Eddy

Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2022-07-22

OAAI

Chen, Jinbiao; Zhao, Yang; Zhang, Fan; Li, Jia; Boland, Jade A.; Cheng, Ngan Ching; Liu, Ken; Tiffen, Jessamy C.; Bertolino, Patrick; Bowen, David G.; Krueger, Andreas; Lisowski, Leszek; Alexander, Ian E.; Vadas, Mathew A.; El-Omar, Emad; Gamble, Jennifer R.; McCaughan, Geoffrey W.

Onasemnogene abeparvovec for the treatment of spinal muscular atrophy

EXPERT OPINION ON BIOLOGICAL THERAPY

IF4

2022-05-02

OAAI

McMillan, Hugh J.; Proud, Crystal M.; Farrar, Michelle A.; Alexander, Ian E.; Muntoni, Francesco; Servais, Laurent

Onasemnogene abeparvovec in spinal muscular atrophy: an Australian experience of safety and efficacy

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

IF3.9

2022-02-16

OAAI

D'Silva, Arlene M.; Holland, Sandra; Kariyawasam, Didu; Herbert, Karen; Barclay, Peter; Cairns, Anita; MacLennan, Suzanna C.; Ryan, Monique M.; Sampaio, Hugo; Smith, Nicholas; Woodcock, Ian R.; Yiu, Eppie M.; Alexander, Ian E.; Farrar, Michelle A.

Angiotensin Converting Enzyme-2 Therapy Improves Liver Fibrosis and Glycemic Control in Diabetic Mice With Fatty Liver

HEPATOLOGY COMMUNICATIONS

IF4.6

2021-12-23

OAAI

Rajapaksha, Indu G.; Gunarathne, Lakmie S.; Asadi, Khashayar; Laybutt, Ross; Andrikopoulous, Sof; Alexander, Ian E.; Watt, Mathew J.; Angus, Peter W.; Herath, Chandana B.

研究方向