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Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis 将具有基因毒性的肠道细菌菌株结合会增加无菌小鼠结肠癌模型中的肿瘤负担并加速其发生 Plitt, Tamar; Piessevaux, Alix; Rajpal, Urvija; Fischer, Jeremy; Spindler, Matthew P.; Ruprecht, Constantin; Li, Zhihua; Mogno, Ilaria; Yang, Ye; Desch, A. Nicole; Chu, Gerald; Jiang, Zhengyu; Wang, Jianyao; Gevers, Dirk; Pocalyko, David; Geis, Abby L.; Jobin, Christian; Bachman, Kurtis E.; Sears, Cynthia L.; Britton, Graham J.; Mateo, Lani R. San; Faith, Jeremiah J. 分享 收藏
Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli Hulpia, F.; Schepens, W.; Lepri, S.; Nicolai, J.; Jiang, Z.; Boj, S.F.; Bush, T.L.; Carvalho, M.A.; Chen, F.; Chu, G.; 等. 发现肠道特异性的PRMT5抑制剂，以阻断具有腺瘤性息肉病 coli基因缺失的肿瘤抑制基因患者的结直肠癌。J. Med. Chem. 2025. [Google Scholar] [CrossRef] [PubMed] Hulpia, Fabian; Schepens, Wim; Lepri, Susan; Nicolai, Johan; Jiang, Zhengyu; Boj, Sylvia F.; Bush, Tammy L.; Carvalho, Mary-ambre; Chen, Falian; Chu, Gerald; Clancy, Kathleen W.; Etwebi, Zienab; Everaerts, Melissa; Fan, Yi; Fernandez Candelaria, Froylan Omar; Francis, Albi; Hixon, Mark S.; Jardi, Ferran; Jin, Shuai; Larin, Egor M.; Last, Stefaan; Leenaerts, Joseph E.; Li, Siyu; Liddane, Alexandra G.; Lutter, Ferdinand H.; Lv, Dan; Mattson, Bethany; Milligan, Cynthia M.; Patrick, Aaron N.; Patwardhan, Gauri Anand; Perez-Benito, Laura; Pieters, Serge; Renders, Evelien; Retzbach, Ed; Smith-Monroy, Constance; Silva, Jose; Silva, Mariana; Sterckx, Hans; ten Hag, Gerben; Thate, Claudia; Van Brandt, Sven; Verissimo, Carla S.; Verniest, Guido; Vesely, Eileen; Vetrano, Irene; Vinken, Petra; Wang, Yufei; Wong, Victoria; Yao, Xuemei; Yang, Jie; Zijlmans, Remco; Bachman, Kurtis E.; Pocalyko, David; Jimenez, Juan-Miguel; Gaffney, Dana; Thuring, Jan Willem 分享 收藏
Comprehensive genomic dependency landscape of a human colon cancer organoid Khalili, Sana; Mohseninia, Atefeh; Liu, Changlong; Banister, Carolyn E.; Heine, Paige; Khazan, Minou; Morrison, Sidney E.; Gokare, Prashanth; Cowley, Glenn S.; Weir, Barbara A.; Pocalyko, David; Bachman, Kurtis E.; Buckhaults, Phillip J. 分享 收藏
Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers 结直肠癌表观遗传和转录亚型的转录因子表达谱基础 Bhandari, Yuba R.; Krishna, Vinod; Powers, Rachael; Parmar, Sehej; Thursby, Sara -Jayne; Gupta, Ekta; Kulak, Ozlem; Gokare, Prashanth; Reumers, Joke; Van Wesenbeeck, Liesbeth; Bachman, Kurtis E.; Baylin, Stephen B.; Easwaran, Hariharan 分享 收藏
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Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer Zhang, Zhuming; Ghosh, Avijit; Connolly, Peter J.; King, Peter; Wilde, Thomas; Wang, Jianyao; Dong, Yawei; Li, Xueliang; Liao, Daohong; Chen, Hao; Tian, Gaochao; Suarez, Javier; Bonnette, William G.; Pande, Vineet; Diloreto, Karen A.; Shi, Yifan; Patel, Shefali; Pietrak, Beth; Szewczuk, Lawrence; Sensenhauser, Carlo; Dallas, Shannon; Edwards, James P.; Bachman, Kurtis E.; Evans, David C. 分享 收藏
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DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer Travers, Meghan; Brown, Stephen M.; Dunworth, Matthew; Holbert, Cassandra E.; Wiehagen, Karla R.; Bachman, Kurtis E.; Foley, Jackson R.; Stone, Meredith L.; Baylin, Stephen B.; Casero, Robert A., Jr.; Zahnow, Cynthia A. 分享 收藏
REPLY TO HAFFNER ET AL.: DNA hypomethylation renders tumors more immunogenic Stone, Meredith L.; Chiappinelli, Katherine B.; Li, Huili; Murphy, Lauren M.; Travers, Meghan E.; Topper, Michael J.; Mathios, Dimitrios; Lim, Michael; Shih, Le-Ming; Wang, Tian-Li; Hung, Chien-Fu; Bhargava, Vipul; Wiehagen, Karla R.; Cowley, Glenn S.; Bachman, Kurtis E.; Strick, Reiner; Strissel, Pamela L.; Baylin, Stephen B.; Zahnow, Cynthia A. 分享 收藏
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes Ai, Rizi; Laragione, Teresina; Hammaker, Deepa; Boyle, David L.; Wildberg, Andre; Maeshima, Keisuke; Palescandolo, Emanuele; Krishna, Vinod; Pocalyko, David; Whitaker, John W.; Bai, Yuchen; Nagpal, Sunil; Bachman, Kurtis E.; Ainsworth, Richard I.; Wang, Mengchi; Ding, Bo; Gulko, Percio S.; Wang, Wei; Firestein, Gary S. 分享 收藏
TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1 Sabins, Nina Chi; Chornoguz, Olesya; Leander, Karen; Kaplan, Fred; Carter, Richard; Kinder, Michelle; Bachman, Kurtis; Verona, Raluca; Shen, Shixue; Bhargava, Vipul; Santulli-Marotto, Sandra 分享 收藏
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden Stone, Meredith L.; Chiappinelli, Katherine B.; Li, Huili; Murphy, Lauren M.; Travers, Meghan E.; Topper, Michael J.; Mathios, Dimitrios; Lim, Michael; Shih, Ie-Ming; Wang, Tian-Li; Hung, Chien-Fu; Bhargava, Vipul; Wiehagen, Karla R.; Cowley, Glenn S.; Bachman, Kurtis E.; Strick, Reiner; Strissel, Pamela L.; Baylin, Stephen B.; Zahnow, Cynthia A. 分享 收藏
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p21WAF1/cIP1 mediates the growth response to TGF-β in human epithelial cells Bachman, KE; Blair, BG; Brenner, K; Bardelli, A; Arena, S; Zhou, SB; Hicks, J; De Marzo, AM; Argani, P; Park, BH 分享 收藏
The PIK3CA gene is mutated with high frequency in human breast cancers Bachman, KE; Argani, P; Samuels, Y; Silliman, N; Ptak, J; Szabo, S; Konishi, H; Karakas, B; Blair, BG; Lin, C; Peters, BA; Velculescu, VE; Park, BH 分享 收藏
Lapatinib inhibits the growth of esophageal squamous cell carcinoma and synergistically interacts with 5-fluorouracil in patient-derived xenograft models Hou, Wenmin; Qin, Xia; Zhu, Xuehua; Fei, Maogui; Liu, Ping; Liu, Li; Moon, Hanlim; Zhang, Pingkuan; Greshock, Joel; Bachman, Kurtis E.; Ye, Bang-Ce; Wang, Hui; Zang, Crystal Ying Qin 分享 收藏
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