Richard J. Smeyne - Publications, H-index & Citations

Richard J. Smeyne

neuroscience

62H指数

158论文数

1.5W被引数

收录论文 49

发表时间

Exposure to manganese during juvenile development increases microglial activation in the hippocampus following systemic infection with A/California/04/2009 Influenza A H1N1 virus 在幼年发育期间接触锰会增强海马体中微胶质细胞的活化，继而在系统性感染A/California/04/2009甲型H1N1流感病毒后出现该现象。

Frontiers in Toxicology

IF4.6

2026-04-03

OAAI

MR Megan R. Hager †; AJ Adam J. Schuller †; OA Omar A. Yanouri †; CM Collin M. Bantle †; RJ Richard J. Smeyne †; RB Ronald B. Tjalkens †

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration 新生儿CMV感染后持续的微胶质细胞活化介导神经退行性变

Science Advances

IF12.5

2026-03-11

OAAI

Jessica L. McCord; Debotri Chatterjee; John Y. S. Han; Drew Scoles; Richard J. Smeyne; Nancy J. Philp; Christopher M. Snyder

Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy 单聚体α-突触核蛋白的模板化导致遗传性诱导型突触核蛋白病小鼠模型中出现炎症和SNpc多巴胺能神经元死亡。

Scientific Reports

IF3.9

2025-07-22

OAAI

Matthew D. Byrne; Peyman Petramfar; Jae-Kyung Lee; Richard Jay Smeyne

Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection 环境暴露和家族背景改变了SARS-CoV-2感染后神经病理和炎症的诱导。

NPJ PARKINSONS DISEASE

IF8.2

2025-04-23

OAAI

Chatterjee, Debotri; Kurup, Drishya; Smeyne, Richard Jay

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

NPJ PARKINSONS DISEASE

IF8.2

2024-04-13

OAAI

Cheslow, Lara; Byrne, Matthew; Kopenhaver, Jessica S.; Iacovitti, Lorraine; Smeyne, Richard J.; Snook, Adam E.; Waldman, Scott A.

In memorium, Michael Zigmond, PhD

NPJ PARKINSONS DISEASE

IF8.2

2023-11-01

OAAI

Smeyne, Richard J.

Microglia-specific knock-out of NF-?B/IKK2 increases the accumulation of misfolded a-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease

GLIA

IF5.1

2023-05-18

OAAI

Rocha, Savannah M.; Kirkley, Kelly S.; Chatterjee, Debotri; Aboellail, Tawfik A.; Smeyne, Richard J.; Tjalkens, Ronald B.

Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment

NATURE AGING

IF19.4

2022-10-12

OAAI

Chen, Ping-Chung; Han, Xian; Shaw, Timothy I.; Fu, Yingxue; Sun, Huan; Niu, Mingming; Wang, Zhen; Jiao, Yun; Teubner, Brett J. W.; Eddins, Donnie; Beloate, Lauren N.; Bai, Bing; Mertz, Joseph; Li, Yuxin; Cho, Ji-Hoon; Wang, Xusheng; Wu, Zhiping; Liu, Danting; Poudel, Suresh; Yuan, Zuo-Fei; Mancieri, Ariana; Low, Jonathan; Lee, Hyeong-Min; Patton, Mary H.; Earls, Laurie R.; Stewart, Elizabeth; Vogel, Peter; Hui, Yawei; Wan, Shibiao; Bennett, David A.; Serrano, Geidy E.; Beach, Thomas G.; Dyer, Michael A.; Smeyne, Richard J.; Moldoveanu, Tudor; Chen, Taosheng; Wu, Gang; Zakharenko, Stanislav S.; Yu, Gang; Peng, Junmin

COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism

MOVEMENT DISORDERS

IF7.6

2022-06-09

OAAI

Smeyne, Richard J.; Eells, Jeffrey B.; Chatterjee, Debotri; Byrne, Matthew; Akula, Shaw M.; Sriramula, Srinivas; O'Rourke, Dorcas P.; Schmidt, Peter

Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice

NEUROBIOLOGY OF DISEASE

IF5.6

2022-06-01

OAAI

Rocha, Savannah M.; Bantle, Collin M.; Aboellail, Tawfik; Chatterjee, Debotri; Smeyne, Richard J.; Tjalkens, Ronald B.

Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson's disease

NPJ PARKINSONS DISEASE

IF8.2

2022-03-15

OAAI

Kozina, Elena; Byrne, Matthew; Smeyne, Richard Jay

Infection and Risk of Parkinson's Disease

JOURNAL OF PARKINSONS DISEASE

IF5

2021-02-02

OAAI

Smeyne, Richard J.; Noyce, Alastair J.; Byrne, Matthew; Savica, Rodolfo; Marras, Connie

COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside

NPJ PARKINSONS DISEASE

IF8.2

2020-08-20

130

OAAI

Sulzer, David; Antonini, Angelo; Leta, Valentina; Nordvig, Anna; Smeyne, Richard J.; Goldman, James E.; Al-Dalahmah, Osama; Zecca, Luigi; Sette, Alessandro; Bubacco, Luigi; Meucci, Olimpia; Moro, Elena; Harms, Ashley S.; Xu, Yaqian; Fahn, Stanley; Chaudhuri, K. Ray

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2019-10-01

OAAI

Fischer, Roman; Padutsch, Tanja; Bracchi-Ricard, Valerie; Murphy, Kayla L.; Martinez, George. F.; Delguercio, Niky; Elmer, Nicholas; Sendetski, Maksim; Diem, Ricarda; Eisel, Ulrich L. M.; Smeyne, Richard J.; Kontermann, Roland E.; Pfizenmaier, Klaus; Bethea, John R.

Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

NPJ PARKINSONS DISEASE

IF8.2

2019-09-13

OAAI

Bantle, Collin M.; Phillips, Aaron T.; Smeyne, Richard J.; Rocha, Savannah M.; Olson, Ken E.; Tjalkens, Ronald B.

Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus

EMBO MOLECULAR MEDICINE

IF8.3

2018-12-05

OAAI

Yang, Junning; Simonneau, Claire; Kilker, Robert; Oakley, Laura; Byrne, Matthew D.; Nichtova, Zuzana; Stefanescu, Ioana; Pardeep-Kumar, Fnu; Tripathi, Sushil; Londin, Eric; Saugier-Veber, Pascale; Willard, Belinda; Thakur, Mathew; Pickup, Stephen; Ishikawa, Hiroshi; Schroten, Horst; Smeyne, Richard; Horowitz, Arie

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo

BRAIN

IF11.7

2018-03-21

OAAI

Kozina, Elena; Sadasivan, Shankar; Jiao, Yun; Dou, Yuchen; Ma, Zhijun; Tan, Haiyan; Kodali, Kiran; Shaw, Timothy; Peng, Junmin; Smeyne, Richard J.

Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multihit hypothesis

NPJ PARKINSONS DISEASE

IF8.2

2017-05-23

OAAI

Sadasivan, Shankar; Sharp, Bridgett; Schultz-Cherry, Stacey; Smeyne, Richard Jay

Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice

JOURNAL OF PARKINSONS DISEASE

IF5

2015-06-01

OAAI

Jiao, Yun; Dou, Yuchen; Lockwood, Georgina; Pani, Amar; Smeyne, Richard Jay

p75 Regulates Purkinje Cell Firing by Modulating SK Channel Activity through Rac1

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-11-01

OAAI

Tian, JinBin; Tep, Chhavy; Benedick, Alex; Saidi, Nabila; Ryu, Jae Cheon; Kim, Mi Lyang; Sadasivan, Shankar; Oberdick, John; Smeyne, Richard; Zhu, Michael X.; Yoon, Sung Ok

研究方向