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Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma Panowski, Siler H.; Srinivasan, Surabhi; Tan, Nguyen; Tacheva-Grigorova, Silvia K.; Smith, Bryan; Mak, Yvonne S. L.; Ning, Hongxiu; Villanueva, Jonathan; Wijewarnasuriya, Dinali; Lang, Shanshan; Melton, Zea; Ghosh, Adit; Dusseaux, Mathilde; Galetto, Roman; Heyen, Jonathan R.; Sai, Tao; Van Blarcom, Thomas; Chaparro-Riggers, Javier; Sasu, Barbra 分享 收藏
DUAL CHECKPOINT BLOCKADE OF CD47 AND PD-L1 USING AN AFFINITY-TUNED BISPECIFIC ANTIBODY MAXIMIZES ANTI-TUMOR IMMUNITY AND IMPROVES THERAPEUTIC WINDOW Chen, Shih-Hsun; Dominik, Pawel; Stanfield, Jessica; Ding, Sheng; Yang, Wenjing; Kurd, Nadia; Llewellyn, Ryan; Heyen, Jonathan; Wang, Carole; Melton, Zea; Lindquist, Kevin; Van Blarcom, Thomas; Chaparro-Riggers, Javier; Salek-Ardakani, Shahram 分享 收藏
Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex Liu, Weifeng; Maben, Zachary; Wang, Carole; Lindquist, Kevin C.; Li, Manqing; Rayannavar, Vinayak; Armenta, Ilsel Lopez; Nager, Andrew; Pascua, Edward; Dominik, Pawel K.; Oyen, David; Wang, Hui; Roach, Rachel Carson; Allan, Corey M.; Mosyak, Lidia; Chaparro-Riggers, Javier 分享 收藏
One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics Chen, Wei; Yang, Fan; Wang, Carole; Narula, Jatin; Pascua, Edward; Ni, Irene; Ding, Sheng; Deng, Xiaodi; Chu, Matthew Ling-Hon; Pham, Amber; Jiang, Xiaoyue; Lindquist, Kevin C.; Doonan, Patrick J.; Van Blarcom, Tom; Yeung, Yik Andy; Chaparro-Riggers, Javier 分享 收藏
Direct control of CAR T cells through small molecule-regulated antibodies Park, Spencer; Pascua, Edward; Lindquist, Kevin C.; Kimberlin, Christopher; Deng, Xiaodi; Mak, Yvonne S. L.; Melton, Zea; Johnson, Theodore O.; Lin, Regina; Boldajipour, Bijan; Abraham, Robert T.; Pons, Jaume; Sasu, Barbra Johnson; Van Blarcom, Thomas J.; Chaparro-Riggers, Javier 分享 收藏
Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery Sommer, Cesar; Cheng, Hsin-Yuan; Nguyen, Duy; Dettling, Danielle; Yeung, Yik Andy; Sutton, Janette; Hamze, Moustafa; Valton, Julien; Smith, Julianne; Djuretic, Ivana; Chaparro-Riggers, Javier; Sasu, Barbra J. 分享 收藏
SMIC CAR T cells: CAR T with temporally-controlled, programmable cytokine signaling outputs Lin, Regina; Nager, Andrew; Park, Spencer; Sutton, Janette; Melton, Zea; Zhang, Yi; Boldajipour, Bijan; Van Blarcom, Tom; Panowski, Siler; Chaparro-Riggers, Javier; Sasu, Barbra 分享 收藏
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An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity Yeung, Yik Andy; Krishnamoorthy, Veena; Dettling, Danielle; Sommer, Cesar; Poulsen, Kris; Ni, Irene; Pham, Amber; Chen, Wei; Liao-Chan, Sindy; Lindquist, Kevin; Chin, S. Michael; Chunyk, Allison Given; Hu, Wenyue; Sasu, Barbra; Chaparro-Riggers, Javier; Djuretic, Ivana 分享 收藏
Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer (vol 9, 8420, 2019) Zhu, Guoyun; Foletti, Davide; Liu, Xiaohui; Ding, Sheng; Witt, Jody Melton; Hasa-Moreno, Adela; Rickert, Mathias; Holz, Charles; Aschenbrenner, Laura; Yang, Amy H.; Kraynov, Eugenia; Evering, Winston; Obert, Leslie; Lee, Chenyu; Sai, Tao; Mistry, Tina; Lindquist, Kevin C.; Van Blarcom, Thomas; Strop, Pavel; Chaparro-Riggers, Javier; Liu, Shu-Hui 分享 收藏
Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma Panowski, Siler H.; Kuo, Tracy C.; Zhang, Yi; Chen, Amy; Geng, Tao; Aschenbrenner, Laura; Kamperschroer, Cris; Pascua, Edward; Chen, Wei; Delaria, Kathy; Farias, Santiago; Bateman, Marjorie; Dushin, Russell G.; Chin, Sherman M.; Van Blarcom, Thomas J.; Yeung, Yik Andy; Lindquist, Kevin C.; Chunyk, Allison G.; Kuang, Bing; Han, Bora; Mirsky, Michael; Pardo, Ingrid; Buetow, Bernard; Martin, Thomas G.; Wolf, Jeffrey L.; Shelton, David; Rajpal, Arvind; Strop, Pavel; Chaparro-Riggers, Javier; Sasu, Barbra J. 分享 收藏
Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer 通过CD3双特异性和ADC模式靶向CLDN18.2治疗胃癌和胰腺癌 Zhu, Guoyun; Foletti, Davide; Liu, Xiaohui; Ding, Sheng; Witt, Jody Melton; Hasa-Moreno, Adela; Rickert, Mathias; Holz, Charles; Aschenbrenner, Laura; Yang, Amy H.; Kraynov, Eugenia; Evering, Winston; Obert, Leslie; Lee, Chenyu; Sai, Tao; Mistry, Tina; Lindquist, Kevin C.; Van Blarcom, Thomas; Strop, Pavel; Chaparro-Riggers, Javier; Liu, Shu-Hui 分享 收藏
Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity Zhang, Pamela; Tu, Guang Huan; Wei, Jie; Santiago, Pamela; Larrabee, Lance R.; Liao-Chan, Sindy; Mistry, Tina; Chu, Matthew Ling-Hon; Sai, Tao; Lindquist, Kevin; Long, Hua; Chaparro-Riggers, Javier; Salek-Ardakani, Shahram; Yeung, Yik Andy 分享 收藏
Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma Sommer, Cesar; Boldajipour, Bijan; Kuo, Tracy C.; Bentley, Trevor; Sutton, Janette; Chen, Amy; Geng, Tao; Dong, Holly; Galetto, Roman; Valton, Julien; Pertel, Thomas; Juillerat, Alexandre; Gariboldi, Annabelle; Pascua, Edward; Brown, Colleen; Chin, Sherman M.; Sai, Tao; Ni, Yajin; Duchateau, Philippe; Smith, Julianne; Rajpal, Arvind; Van Blarcom, Thomas; Chaparro-Riggers, Javier; Sasu, Barbra J. 分享 收藏
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab 4-1BB/4-1BBL复合物的结构以及utomilumab和urelumab的独特结合和功能特性 Chin, S. Michael; Kimberlin, Christopher R.; Roe-Zurz, Zygy; Zhang, Pamela; Xu, Allison; Liao-Chan, Sindy; Sen, Debasish; Nager, Andrew R.; Oakdale, Nicole Schirle; Brown, Colleen; Wang, Feng; Yang, Yuting; Lindquist, Kevin; Yeung, Yik Andy; Salek-Ardakani, Shahram; Chaparro-Riggers, Javier 分享 收藏
Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies 生产性共同轻链文库产生多种高亲和力双特异性抗体 Van Blarcom, Thomas; Lindquist, Kevin; Melton, Zea; Cheung, Wai Ling; Wagstrom, Chris; McDonough, Dan; Oseguera, Cendy Valle; Ding, Sheng; Rossi, Andrea; Potluri, Shobha; Sundar, Purnima; Pitts, Steven; Sirota, Marina; Casas, Meri Galindo; Yan, Yu; Jones, Jeffrey; Roe-Zurz, Zygy; Srinivasan, Surabhi Srivatsa; Zhai, Wenwu; Pons, Jaume; Rajpal, Arvind; Chaparro-Riggers, Javier 分享 收藏
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire Yeung, Yik Andy; Foletti, Davide; Deng, Xiaodi; Abdiche, Yasmina; Strop, Pavel; Glanville, Jacob; Pitts, Steven; Lindquist, Kevin; Sundar, Purnima D.; Sirota, Marina; Hasa-Moreno, Adela; Pham, Amber; Witt, Jody Melton; Ni, Irene; Pons, Jaume; Shelton, David; Rajpal, Arvind; Chaparro-Riggers, Javier 分享 收藏
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity 新生儿Fc受体 (FcRn) 以相同的亲和力独立结合IgG同型二聚体的两个位点 Abdiche, Yasmina Noubia; Yeung, Yik Andy; Chaparro-Riggers, Javier; Barman, Ishita; Strop, Pavel; Chin, Sherman Michael; Pham, Amber; Bolton, Gary; McDonough, Dan; Lindquist, Kevin; Pons, Jaume; Rajpal, Arvind 分享 收藏
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