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袁

袁正宏 (Zhenghong Yuan)

fudan university

60H指数
293论文数
1.7W被引数
收录论文 155
发表时间
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Generation of HBV cccDNA using single-stranded M13 phage DNA for authentic minichromosome functionality利用单链M13噬菌体DNA生成HBV cccDNA以实现真核微型染色体功能
errJournal of Virology
IF3.8
err2026-06-23
err0
PREAI
errLi, Yumeng; Hua, Ting; Hao, Menghan; Chen, Liman; Huang, Wenjun; Fang, Zhong; Ashuo, Asha; Li, Yaming; Yi, Zhigang; Gu, Hongzhou; Yuan, Zhenghong; Chen, Jieliang
err分享
err收藏
Repurposing Screen Using a Robust Human Rhinovirus Infectious Clone Identifies Pyrvinium Pamoate with Antiviral Activity利用稳健的人鼻病毒感染性克隆的药物重定位筛选鉴定出具有抗病毒活性的噻嘧啶盐酸盐
errAntiviral Research
IF4
err2026-04-21
err0
PREAI
errLinlin Pang; Jingyi Zou; Zhenghong Yuan; Ping Zhao; Zhigang Yi
err分享
err收藏
Structural and functional insights into HBx–Smc6 targeting for HBV inhibition结构和功能的见解为HBV抑制HBx-Smc6靶向
errCell Research
IF25.9
err2026-04-16
err0
PREAI
errTong Cheng; Jinhong Zhou; Wenjun Huang; Lili Du; Pengyu He; Renzheng Yang; Yan Gao; Menghan Hao; Kongying Hu; Jieliang Chen; Hongxia Wang; Zihe Rao; Zhenghong Yuan; Lanfeng Wang
err分享
err收藏
SARS-CoV-2 polyprotein expression and the induction of double-membrane vesicles
errJOURNAL OF VIROLOGY
IF3.8
err2025-11-01
err1
PREAI
errZhao, Meng; Zhang, Yajie; Liang, Yakun; Lei, Fuzhi; Han, Yuying; Yuan, Zhenghong; Yi, Zhigang
err分享
err收藏
Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure干扰素-α在慢性乙型肝炎免疫调节中实现功能性治愈
errViruses 2025, Vol. 17, Page 1358
IF0
err2025-10-10
err0
errOAAI
errAsha Ashuo; Jia Liu; Zhenghong Yuan; Jieliang Chen
err分享
err收藏
Viral Determinants of Cis- and Trans-Cleavage by SARS-CoV-2 Nsp3 and an On-Off Reporter for Monitoring Intracellular Protease ActivitySARS-CoV-2 Nsp3介导顺式和反式切割的病毒决定因子及一种用于监测细胞内蛋白酶活性的开关报告系统
errAntiviral Research
IF4
err2025-08-18
err0
PREAI
errFuzhi Lei; Jun Shu; Chengjie Xia; Yahan Lei; Yajie Zhang; Yang Zhang; Zhenghong Yuan; Zhigang Yi
err分享
err收藏
Residual viral expression in siRNA-treated HBV-replicating cell and mouse modelssiRNA处理的人乙型肝炎病毒（HBV）复制细胞和小鼠模型中的残余病毒表达
errAntiviral Research
IF4
err2025-06-05
err0
PREAI
errMingzhu Xu; Yuyan Qian; Ziyang Song; Haiyu Wang; Lei Yue; Jiangxia Liu; Yaming Li; Wenjing Zai; Zhenghong Yuan; Jieliang Chen
err分享
err收藏
Extrathymic CD8 and CD4 Double Positive T Cells Presenting Vigorous HBV-Specific Responses Accelerate HBV Clearance胸外CD8和CD4双阳性T细胞表现出强烈的HBV特异性反应，加速HBV清除
errJOURNAL OF MEDICAL VIROLOGY
IF4.6
err2025-03-25
err0
PREAI
errFang, Zhong; Wang, Cong; Huang, Chen-lu; Tan, Dan; Peng, Xiu-hua; Bai, Jin-jin; Yuan, Zheng-hong; Yu, Xiao-yu; Ren, Guang-xu
err分享
err收藏
Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy
errMBIO
IF4.7
err2024-12-11
err1
errOAAI
errHu, Kongying; Zai, Wenjing; Xu, Mingzhu; Wang, Haiyu; Song, Xinluo; Huang, Chao; Liu, Jiangxia; Chen, Juan; Deng, Qiang; Yuan, Zhenghong; Chen, Jieliang
err分享
err收藏
Potential role of liver-resident CD3+ macrophages in HBV clearance in a mouse hepatitis B model肝脏驻留CD3+巨噬细胞在HBV清除中的潜在作用：小鼠乙型肝炎模型研究
errJHEP REPORTS
IF7.5
err2024-12-01
err0
errOAAI
errWang, Cong; Zai, Wenjing; Zhao, Kuangjie; Li, Yaming; Shi, Bisheng; Wu, Min; Zhou, Xiaohui; Kozlowski, Maya; Zhang, Xiaonan; Fang, Zhong; Yuan, Zhenghong
err分享
err收藏
Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening
errACTA PHARMACEUTICA SINICA B
IF14.6
err2024-11-01
err0
errOAAI
errHuang, Chao; Jin, Yang; Fu, Panpan; Hu, Kongying; Wang, Mengxue; Zai, Wenjing; Hua, Ting; Song, Xinluo; Ye, Jianyu; Zhang, Yiqing; Luo, Gan; Wang, Haiyu; Liu, Jiangxia; Chen, Jieliang; Li, Xuwen; Yuan, Zhenghong
err分享
err收藏
Liver mechanosignaling as a natural anti-hepatitis B virus mechanism
errNATURE COMMUNICATIONS
IF15.7
err2024-09-27
err0
errOAAI
errYe, Jianyu; Li, Fahong; Hua, Ting; Ma, Kewei; Wang, Jinyu; Zhao, Zixin; Yang, Zhongning; Luo, Chen; Jia, Ruohan; Li, Yaming; Hao, Menghan; Wu, Jian; Lu, Mengji; Yuan, Zhenghong; Zhang, Jiming; Chen, Jieliang
err分享
err收藏
Modulation of monocyte activity by hepatocellular MicroRNA delivery through HBsAg particles: Implications for pathobiology of chronic hepatitis B
errHEPATOLOGY
IF15.8
err2024-06-20
err0
PREAI
errLi, Jin; Ma, Xiao; Xuan, Qinkao; Li, Qiang; Wu, Min; Shi, Bisheng; Fang, Zhong; Chen, Liang; Chen, Jieliang; Wen, Yumei; Zhu, Chuanwu; Zhu, Li; Zhang, Xiaonan; Yuan, Zhenghong
err分享
err收藏
Identification of a membrane-associated element (MAE) in the C-terminal region of SARS-CoV-2 nsp6 that is essential for viral replication
errJOURNAL OF VIROLOGY
IF3.8
err2024-05-14
err1
PREAI
errHan, Yuying; Yuan, Zhenghong; Yi, Zhigang
err分享
err收藏
An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes用于分析人干扰素 α 和亚型的细胞外人源化IFNAR免疫活性小鼠模型
errEMERGING MICROBES & INFECTIONS
IF7.5
err2024-01-22
err2
errOAAI
errLi, Yumeng; Ashuo, Asha; Hao, Menghan; Li, Yaming; Ye, Jianyu; Liu, Jiangxia; Hua, Ting; Fang, Zhong; Li, Jianhua; Yuan, Zhenghong; Chen, Jieliang
err分享
err收藏
Zika virus infection triggers caspase cleavage of STAT1
errMICROBIOLOGY SPECTRUM
IF3.8
err2024-01-11
err1
errOAAI
errShu, Jun; Ma, Xiao; Zou, Jingyi; Yuan, Zhenghong; Yi, Zhigang
err分享
err收藏
Structural biology of SARS-CoV-2 Mpro and drug discoverySARS-CoV-2 Mpro的结构生物学和药物发现
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2023-10-01
err18
PREAI
errDuan, Yinkai; Wang, Haofeng; Yuan, Zhenghong; Yang, Haitao
err分享
err收藏
Illuminating the Live-Cell Dynamics of Hepatitis B Virus Covalently Closed Circular DNA Using the CRISPR-Tag System
errMBIO
IF4.7
err2023-04-25
err5
errOAAI
errDing, Jiahui; Yi, Zhigang; Zai, Wenjing; Wu, Min; Chen, Baohui; Cai, Qiliang; Zhang, Xiaonan; Yuan, Zhenghong
err分享
err收藏
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection
errPROTEIN & CELL
IF12.8
err2022-08-23
err1
errOAAI
errFeng, Fei; Zhu, Yunkai; Ma, Yanlong; Wang, Yuyan; Yu, Yin; Sun, Xinran; Song, Yuanlin; Shao, Zhugui; Huang, Xinxin; Liao, Ying; Ma, Jingyun; He, Yuping; Wang, Mingyuan; Tang, Longhai; Huang, Yaowei; Zhao, Jincun; Ding, Qiang; Xie, Youhua; Cai, Qiliang; Xiao, Hui; Li, Chun; Yuan, Zhenghong; Zhang, Rong
err分享
err收藏
A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments
errNATURE COMMUNICATIONS
IF15.7
err2022-08-08
err15
errOAAI
errWang, Yang; Yuan, Wenjie; Guo, Siqi; Li, Qiqi; Chen, Xiaomei; Li, Cheng; Liu, Qianying; Sun, Lei; Chen, Zhenguo; Yuan, Zhenghong; Luo, Cheng; Chen, Shijie; Tong, Shuping; Nassal, Michael; Wen, Yu-Mei; Wang, Yong-Xiang
err分享
err收藏

研究方向

乙肝慢性化机制及治愈策略乙肝病毒拮抗逃逸天然免疫干扰素系统导致疾病迁延难愈的作用及分子机制乙肝病毒cccDNA分布及表观调控机制新发传染病监测与防控H7N9禽流感病毒鉴定与研究
合作学者
合作期刊
S
Simon I Hay
H 指数: 231 · 论文数: 900
王
王军 (Jun Wang)
H 指数: 222 · 论文数: 3.2K
M
Malik Peiris
H 指数: 167 · 论文数: 1.5K
C
Charles M. Rice
H 指数: 166 · 论文数: 718
A
Adolfo Garcı́a-Sastre
H 指数: 161 · 论文数: 1.1K
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