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收藏The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts
Xue, Zhiyi; Mladek, Ann C.; Rathi, Sneha; Jain, Sonia; Vaubel, Rachael A.; Odukoya, Lateef A.; Garcia, Darwin A.; Liu, Lily; Bakken, Katrina K.; Carlson, Brett L.; Ott, Lauren L.; Burgenske, Danielle M.; Hu, Zeng; Dragojevic, Sonja; Decker, Paul A.; Kosel, Matthew L.; Breen, William G.; Gupta, Shiv K.; Eckel-Passow, Jeanette E.; Elmquist, William F.; Zhong, Wei; Sarkaria, Jann N. 分享 收藏 ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastomaLaverty, Daniel J.; Gupta, Shiv K.; Bradshaw, Gary A.; Hunter, Alexander S.; Carlson, Brett L.; Calmo, Nery Matias; Chen, Jiajia; Tian, Shulan; Sarkaria, Jann N.; Nagel, Zachary D. 分享 收藏 Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma ModelsJain, Sonia; Griffith, Jessica I.; Porath, Kendra A.; Rathi, Sneha; Le, Jiayan; Pasa, Tugce I.; Decker, Paul A.; Gupta, Shiv K.; Hu, Zeng; Carlson, Brett L.; Bakken, Katrina; Burgenske, Danielle M.; Feldsien, Thomas M.; Lefebvre, Didier R.; Vaubel, Rachael A.; Eckel-Passow, Jeanette E.; Reilly, Edward B.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitizationChen, Jiajia; Laverty, Daniel J.; Talele, Surabhi; Bale, Ashwin; Carlson, Brett L.; Porath, Kendra A.; Bakken, Katrina K.; Burgenske, Danielle M.; Decker, Paul A.; Vaubel, Rachael A.; Eckel-Passow, Jeanette E.; Bhargava, Rohit; Lou, Zhenkun; Hamerlik, Petra; Harley, Brendan; Elmquist, William F.; Nagel, Zachary D.; Gupta, Shiv K.; Sarkaria, Jann N. 分享 收藏 Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis XenograftsJi, Jianxiang; Dragojevic, Sonja; Callaghan, Cameron M.; Smith, Emily J.; Talele, Surabhi; Zhang, Wenjuan; Connors, Margaret A.; Mladek, Ann C.; Hu, Zeng; Bakken, Katrina K.; Sarkaria, Paige P.; Carlson, Brett L.; Burgenske, Danielle M.; Decker, Paul A.; Rashid, Mohammad Abdur; Jang, Mi-hyeon; Gupta, Shiv K.; Eckel-Passow, Jeanette E.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenograftsXue, Zhiyi; Mladek, Ann C.; Rathi, Sneha; Burgenske, Danielle M.; Gupta, Shiv K.; Carlson, Brett L.; Hu, Zeng; Ott, Lauren L.; Bakken, Katrina K.; Vaubel, Rachael A.; Elimquist, William F.; Zhong, Wei; Sarkaria, Jann N. 分享 收藏 分享 收藏 分享 收藏 Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenograftsPorath, Kendra A.; Regan, Michael S.; Griffith, Jessica, I; Jain, Sonia; Stopka, Sylwia A.; Burgenske, Danielle M.; Bakken, Katrina K.; Carlson, Brett L.; Decker, Paul A.; Vaubel, Rachael A.; Dragojevic, Sonja; Mladek, Ann C.; Connors, Margaret A.; Hu, Zeng; He, Lihong; Kitange, Gaspar J.; Gupta, Shiv K.; Feldsien, Thomas M.; Lefebvre, Didier R.; Agar, Nathalie Y. R.; Eckel-Passow, Jeanette E.; Reilly, Edward B.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of GlioblastomaTalele, Surabhi; Zhang, Wenjuan; Burgenske, Danielle M.; Kim, Minjee; Mohammad, Afroz S.; Dragojevic, Sonja; Gupta, Shiv K.; Bindra, Ranjit S.; Sarkaria, Jann N.; Elmquist, William F. 分享 收藏 Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastomaMarin, Bianca-Maria; Porath, Kendra A.; Jain, Sonia; Kim, Minjee; Conage-Pough, Jason E.; Oh, Ju-Hee; Miller, Caitlyn L.; Talele, Surabhi; Kitange, Gaspar J.; Tian, Shulan; Burgenske, Danielle M.; Mladek, Ann C.; Gupta, Shiv K.; Decker, Paul A.; McMinn, Madison H.; Stopka, Sylwia A.; Regan, Michael S.; He, Lihong; Carlson, Brett L.; Bakken, Katrina; Burns, Terence C.; Parney, Ian F.; Giannini, Caterina; Agar, Nathalie Y. R.; Eckel-Passow, Jeanette E.; Cochran, Jennifer R.; Elmquist, William F.; Vaubel, Rachael A.; White, Forest M.; Sarkaria, Jann N. 分享 收藏 In Vivo Efficacy of Tesevatinib in EGFR-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory SignalingKizilbash, Sani H.; Gupta, Shiv K.; Parrish, Karen E.; Laramy, Janice K.; Kim, Minjee; Gampa, Gautham; Carlson, Brett L.; Bakken, Katrina K.; Mladek, Ann C.; Schroeder, Mark A.; Decker, Paul A.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 Brain penetrant MDM2 inhibitor RG7388 extends survival benefit of radiation treatment in select glioblastoma patient-derived xenograft modelsGupta, Shiv K.; Mladek, Ann C.; Telele, Surabhi; Mohammad, Afroz S.; He, Lihong; Hu, Zeng; Bakken, Katrina K.; Burgenske, Danielle M.; Carlson, Brett L.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 Inhibition of DNA-PKcs by M3814 potentiates efficacy of ionizing radiation in patient derived xenografts of melanoma brain metastasesJi, Jianxiong; Smith, Emily J.; Sarkaria, Paige; Mladek, Ann C.; Talele, Surabhi; Swanson, Katelyn; Mohammad, Afroz S.; He, Lihong; Hu, Zeng; Bakken, Katrina K.; Gupta, Shiv K.; Burgenske, Danielle M.; Kitange, Gaspar J.; Elmquist, William F.; Sarkaria, Jann N. 分享 收藏 Targeting ATM with AZD1390 for radio-sensitization of glioblastoma patient derived xenograftsChen, Jiajia; Gupta, Shiv K.; Kitange, Gaspar J.; Mladek, Ann C.; Carlson, Brett L.; He, Lihong; Hu, Zeng; Bakken, Katrina K.; Burgenske, Danielle M.; Connors, Margaret A.; Sarkaria, Jann N. 分享 收藏 A promising blood-brainbarrier penetrant MDM2-p53 antagonist, BI-MDM2, increases survival in orthotopic, glioblastoma patient-derived xenograft modelsTuma, Ann C. Mladek; Gupta, Shiv; Talele, Surabhi; Mohammad, Afroz Shareef; Bakken, Katrina K.; He, Helen; Hu, Zeng; Connors, Margaret A.; Burgenske, Danielle M.; Carlson, Brett L.; Elmquist, William F.; Weyer-Czernilofsky, Ulrike; Sarkaria, Jann N. 分享 收藏 分享 收藏 MDM2 inhibitor KRT-232 extends survival in glioblastoma patient-derived xenograft modelsMladek, Ann C.; Gupta, Shiv; Kim, Minjee; Mohammad, Afroz Shareef; Bakken, Katrina K.; He, Helen; Hu, Zeng; Burgenske, Danielle M.; Carlson, Brett L.; Elmquist, William F.; Sarkaria, Jann 分享 收藏 分享 收藏 
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