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Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism Sikorska, Justyna; Hou, Yan; Chiurazzi, Paul; Siu, Tony; Baltus, Gretchen A.; Sheth, Payal; McLaren, David G.; Truong, Quang; Parish, Craig A.; Wyss, Daniel F. 分享 收藏
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors Tiedt, Ralph; King, Frederick J.; Stamm, Christelle; Niederst, Matthew J.; Delach, Scott; Zumstein-Mecker, Sabine; Meltzer, Jodi; Mulford, Iain J.; Labrot, Emma; Engstler, Barbara Schacher; Baltschukat, Sabrina; Kerr, Grainne; Golji, Javad; Wyss, Daniel; Schnell, Christian; Ainscow, Edward; Engelman, Jeffrey A.; Sellers, William R.; Barretina, Jordi; Caponigro, Giordano; Porta, Diana Graus 分享 收藏
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta- Lactamase Inhibitors: Initial Leads toward Clinical Candidates Mandal, Mihirbaran; Xiao, Li; Pan, Weidong; Scapin, Giovanna; Li, Guoqing; Tang, Haiqun; Yang, Shu-Wei; Pan, Jianping; Root, Yuriko; de Jesus, Reynalda Keh; Yang, Christine; Prosise, Winnie; Dayananth, Priya; Mirza, Asra; Therien, Alex G.; Young, Katherine; Flattery, Amy; Garlisi, Charles; Zhang, Rumin; Chu, Donald; Sheth, Payal; Chu, Inhou; Wu, Jin; Markgraf, Carrie; Kim, Hai-Young; Painter, Ronald; Mayhood, Todd W.; DiNunzio, Edward; Wyss, Daniel F.; Buevich, Alexei, V; Fischmann, Thierry; Pasternak, Alexander; Dong, Shuzhi; Hicks, Jacqueline D.; Villafania, Artjohn; Liang, Lianzhu; Murgolo, Nicholas; Black, Todd; Hagmann, William K.; Tata, Jim; Parmee, Emma R.; Weber, Ann E.; Su, Jing; Tang, Haifeng 分享 收藏
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer Chang, Wonsuk; Altman, Michael D.; Lesburg, Charles A.; Perera, Samanthi A.; Piesvaux, Jennifer A.; Schroeder, Gottfried K.; Wyss, Daniel F.; Cemerski, Saso; Chen, Yiping; DiNunzio, Edward; Haidle, Andrew M.; Ho, Thu; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny E.; Lacey, Brian M.; Laskey, Jason; Lim, Jongwon; Long, Brian J.; Ma, Yanhong; Maddess, Matthew L.; Pan, Bo-Sheng; Presland, Jeremy P.; Spooner, Edward; Steinhuebel, Dietrich; Quang Truong; Zhang, Zhibo; Fu, Jianmin; Addona, George H.; Northrup, Alan B.; Parmee, Emma; Tata, James R.; Bennett, David Jonathan; Cumming, Jared N.; Siu, Tony; Trotter, B. Wesley 分享 收藏
SGLT2 inhibition improves BYL719-induced hyperglycemia and hyperinsulinemia in rat pre-clinical models Schnell, Christian R.; Wyss, Daniel; Tinetto, Walter; Ferrat, Thomas; Gao, Jiaping; Darrell, Panza; Gold, Josh; Beaulieu, Valerie; Diener, John; Fritsch, Christine 分享 收藏
Pyrazolopyrimidines as novel selective allosteric MALT1 inhibitors with in vivo activity in ABC-DLBCL Weiss, Andreas; Radimerski, Thomas; Wyss, Daniel; Andraos, Rita; Buhles, Alexandra; Sterker, Dario; Quancard, Jean; Pissot, Carole; Simic, Oliver; Bigaud, Marc; Bornancin, Frederic; Schlapbach, Achim; Regnier, Catherine; McSheehy, Paul; Buchdunger, Elisabeth; Wartmann, Markus; Renatus, Martin; Endres, Ralf; Sellers, William; Hofmann, Francesco 分享 收藏
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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response 使用患者来源的肿瘤异种移植物进行高通量筛选以预测临床试验药物反应 Gao, Hui; Korn, Joshua M.; Ferretti, Stephane; Monahan, John E.; Wang, Youzhen; Singh, Mallika; Zhang, Chao; Schnell, Christian; Yang, Guizhi; Zhang, Yun; Balbin, O. Alejandro; Barbe, Stephanie; Cai, Hongbo; Casey, Fergal; Chatterjee, Susmita; Chiang, Derek Y.; Chuai, Shannon; Cogan, Shawn M.; Collins, Scott D.; Dammassa, Ernesta; Ebel, Nicolas; Embry, Millicent; Green, John; Kauffmann, Audrey; Kowa, Colleen; Leary, Rebecca J.; Lehar, Joseph; Liang, Ying; Loo, Alice; Lorenzana, Edward; McDonald, E. Robert, III; McLaughlin, Margaret E.; Merkin, Jason; Meyer, Ronald; Naylor, Tara L.; Patawaran, Montesa; Reddy, Anupama; Roeelli, Claudia; Ruddy, David A.; Salangsang, Fernando; Santacroce, Francesca; Singh, Angad P.; Tang, Yan; Tinetto, Walter; Tobler, Sonja; Velazquez, Roberto; Venkatesan, Kavitha; Von Arx, Fabian; Wang, Hui Qin; Wang, Zongyao; Wiesmann, Marion; Wyss, Daniel; Xu, Fiona; Bitter, Hans; Atadja, Peter; Lees, Emma; Hofmann, Francesco; Li, En; Keen, Nicholas; Cozens, Robert; Jensen, Michael Rugaard; Pryer, Nancy K.; Williams, Juliet A.; Sellers, William R. 分享 收藏
The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors Labroli, Marc A.; Dwyer, Michael P.; Shen, Ruichao; Popovici-Muller, Janeta; Pu, Qinglin; Wyss, Daniel; McCoy, Mark; Barrett, Dianah; Davis, Nicole; Seghezzi, Wolfgang; Shanahan, Frances; Taricani, Lorena; Beaumont, Maribel; Malinao, Maria-Christina; Parry, David; Guzi, Timothy J. 分享 收藏
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors Huang, Xiaohua; Shipps, Gerald W., Jr.; Cheng, Cliff C.; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A.; Wyss, Daniel F.; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K.; Murphy, Denise M.; Whitehurst, Charles E. 分享 收藏
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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase Cheng, Cliff C.; Huang, Xiaohua; Shipps, Gerald W., Jr.; Wang, Yu-Sen; Wyss, Daniel F.; Soucy, Kyle A.; Jiang, Chuan-kui; Agrawal, Sony; Ferrari, Eric; He, Zhiqing; Huang, H-C 分享 收藏
The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist Baur, Francois; Beattie, David; Beer, David; Bentley, David; Bradley, Michelle; Bruce, Ian; Charlton, Steven J.; Cuenoud, Bernard; Ernst, Roland; Fairhurst, Robin A.; Faller, Bernard; Farr, David; Keller, Thomas; Fozard, John R.; Fullerton, Joe; Garman, Sheila; Hatto, Julia; Hayden, Claire; He, Handan; Howes, Colin; Janus, Diana; Jiang, Zhengjin; Lewis, Christine; Loeuillet-Ritzler, Frederique; Moser, Heinz; Reilly, John; Steward, Alan; Sykes, David; Tedaldi, Lauren; Trifilieff, Alexandre; Tweed, Morris; Watson, Simon; Wissler, Elke; Wyss, Daniel 分享 收藏
Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation Zhu, Zhaoning; Sun, Zhong-Yue; Ye, Yuanzan; Voigt, Johannes; Strickland, Corey; Smith, Elizabeth M.; Cumming, Jared; Wang, Lingyan; Wong, Jesse; Wang, Yu-Sen; Wyss, Daniel F.; Chen, Xia; Kuvelkar, Reshma; Kennedy, Matthew E.; Favreau, Leonard; Parker, Eric; McKittrick, Brian A.; Stamford, Andrew; Czarniecki, Michael; Greenlee, William; Hunter, John C. 分享 收藏
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors Wang, Yu-Sen; Strickland, Corey; Voigt, Johannes H.; Kennedy, Matthew E.; Beyer, Brian M.; Senior, Mary M.; Smith, Elizabeth M.; Nechuta, Terry L.; Madison, Vincent S.; Czarniecki, Michael; McKittrick, Brian A.; Stamford, Andrew W.; Parker, Eric M.; Hunter, John C.; Greenlee, William J.; Wyss, Daniel F. 分享 收藏
Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males Svensson, J; Ohlsson, C; Jansson, JO; Murphy, G; Wyss, D; Krupa, D; Cerchio, K; Polvino, W; Gertz, B; Baylink, D; Mohan, S; Bengtsson, BÅ 分享 收藏
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