Timothy F. Osborne - Publications, H-index & Citations

Timothy F. Osborne

johns hopkins university

70H指数

186论文数

2.0W被引数

收录论文 105

发表时间

Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling 葡萄糖激活的JMJD1A通过α-酮戊二酸依赖的染色质重塑驱动内脏脂肪生成

Cell Reports

IF6.9

2025-07-26

OAAI

Chenxu Yang; Makoto Arai; Eko Fuji Ariyanto; Ji Zhang; Debby Mirani Lubis; Ryo Ito; Shiyu Xie; Mio Nitta; Fuka Kawashima; Tomofumi Ishitsuka; Chaoran Yang; Tomohiro Suzuki; Tetsuro Komatsu; Hina Sagae; Hitomi Jin; Hiroki Takahashi; Eri Kobayashi; Yuchen Wei; Bohao Liu; Hyunmi Choi; Youichiro Wada; Toshiya Tanaka; Tsuyoshi Osawa; Hiroshi Kimura; Tatsuhiko Kodama; Hiroyuki Aburatani; Makoto Tachibana; Yoichi Shinkai; Takeshi Inagaki; Tomoyoshi Soga; Timothy F. Osborne; Takeshi Yoneshiro; Yoshihiro Matsumura; Juro Sakai

SETDB2 regulates the Innate Immune Memory response and influences Inflammatory Immune landscape in Atherosclerosis SETDB2调控先天免疫记忆反应，并影响动脉粥样硬化中的炎症免疫景观

CIRCULATION

IF38.6

2024-11-12

PREAI

Jaiswal, Anant; Halasz, Laszlo; Suarez, Yajaira; Fernandez-Hernando, Carlos; Osborne, Timothy

Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2024-04-16

OAAI

Lee, Eun-Ho; Lee, Jae-Ho; Kim, Do-Young; Lee, Young-Seung; Jo, Yunju; Dao, Tam; Kim, Kyung Eun; Song, Dae-Kyu; Seo, Ji Hae; Seo, Young-Kyo; Seong, Je Kyung; Moon, Changjong; Han, Eugene; Kim, Mi Kyung; Ryu, Seungwan; Shin, Minsang; Roh, Gu Seob; Jung, Hye Ra; Osborne, Timothy F.; Ryu, Dongryeol; Jeon, Tae-Il; Im, Seung-Soon

Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2024-04-01

OAAI

Divoux, Adeline; Whytock, Katie L.; Halasz, Laszlo; Hopf, Meghan E.; Sparks, Lauren M.; Osborne, Timothy F.; Smith, Steven R.

Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women

CELLS

IF5.2

2023-12-30

OAAI

Erdos, Edina; Sandor, Katalin; Young-Erdos, Crystal L.; Halasz, Laszlo; Smith, Steven R.; Osborne, Timothy F.; Divoux, Adeline

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis

NATURE COMMUNICATIONS

IF15.7

2023-12-13

OAAI

Muta, Yu; Linares, Juan F.; Martinez-Ordonez, Anxo; Duran, Angeles; Cid-Diaz, Tania; Kinoshita, Hiroto; Zhang, Xiao; Han, Qixiu; Nakanishi, Yuki; Nakanishi, Naoko; Cordes, Thekla; Arora, Gurpreet K.; Ruiz-Martinez, Marc; Reina-Campos, Miguel; Kasashima, Hiroaki; Yashiro, Masakazu; Maeda, Kiyoshi; Albaladejo-Gonzalez, Ana; Torres-Moreno, Daniel; Garcia-Solano, Jose; Conesa-Zamora, Pablo; Inghirami, Giorgio; Metallo, Christian M.; Osborne, Timothy F.; Diaz-Meco, Maria T.; Moscat, Jorge

Identification of the novel role of sterol regulatory element binding proteins (SREBPs) in mechanotransduction and intraocular pressure regulation 鉴定固醇调节元件结合蛋白 (SREBPs) 在机械转导和眼压调节中的新作用

FASEB JOURNAL

IF4.2

2023-10-12

OAAI

Wang, Ting; Soundararajan, Avinash; Rabinowitz, Jeffrey; Jaiswal, Anant; Osborne, Timothy; Pattabiraman, Padmanabhan Paranji

Opportunistic screening for osteoporosis by abdominal CT in a British population 通过腹部CT对英国人群进行骨质疏松症的机会性筛查

INSIGHTS INTO IMAGING

IF4.5

2023-04-01

OAAI

Vadera, Sonam; Osborne, Timothy; Shah, Vikas; Stephenson, James A.

Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: A critical role for the btd domain of Sp1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

OAAI

Athanikar, JN; Sanchez, HB; Osborne, TF

Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Zoumi, A; Datta, S; Liaw, LHL; Wu, CJ; Manthripragada, G; Osborne, TF; LaMorte, VJ

Hepatocyte nuclear factor 4α contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9 肝细胞核因子4α 通过与GATA4和Kruppel样转录因子9协同调节1型碘甲状腺素脱碘酶基因来促进甲状腺激素稳态

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Ohguchi, Hiroto; Tanaka, Toshiya; Uchida, Aoi; Magoori, Kenta; Kudo, Hiromi; Kim, Insook; Daigo, Kenji; Sakakibara, Iori; Okamura, Masashi; Harigae, Hideo; Sasaki, Takeshi; Osborne, Timothy F.; Gonzalez, Frank J.; Hamakubo, Takao; Kodama, Tatsuhiko; Sakai, Juro

Cooperative interaction between hepatocyte nuclear factor 4α and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8 肝细胞核因子4α 和GATA转录因子之间的协同相互作用调节ATP结合盒固醇转运蛋白ABCG5和ABCG8

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Sumi, Koichi; Tanaka, Toshiya; Uchida, Aoi; Magoori, Kenta; Urashima, Yasuyo; Ohashi, Riuko; Ohguchi, Hiroto; Okamura, Masashi; Kudo, Hiromi; Daigo, Kenji; Maejima, Takashi; Kojima, Noriaki; Sakakibara, Iori; Jiang, Shuying; Hasegawa, Go; Kim, Insook; Osborne, Timothy F.; Naito, Makoto; Gonzalez, Frank J.; Hamakubo, Takao; Kodama, Tatsuhiko; Sakai, Juro

Selective coactivator interactions in gene activation by SREBP-1a and-1c

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

123

OAAI

Toth, JI; Datta, S; Athanikar, JN; Freedman, LP; Osborne, TF

Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2 (vol 29, pg 4864, 2009)

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Im, Seung-Soon; Hammond, Linda E.; Yousef, Leyla; Nugas-Selby, Cherryl; Shin, Dong-Ju; Seo, Young-Kyo; Fong, Loren G.; Young, Stephen G.; Osborne, Timothy F.

Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2 固醇调节元件结合蛋白1a通过激活乙酰辅酶a羧化酶2调节肝脏脂肪酸分配

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Im, Seung-Soon; Hammond, Linda E.; Yousef, Leyla; Nugas-Selby, Cherryl; Shin, Dong-Ju; Seo, Young-Kyo; Fong, Loren G.; Young, Stephen G.; Osborne, Timothy F.

Protection from Bacterial-Toxin-Induced Apoptosis in Macrophages Requires the Lipogenic Transcription Factor Sterol Regulatory Element Binding Protein 1a

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Im, Seung-Soon; Osborne, Timothy F.

Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-03

OAAI

Liebergall, Sophie R.; Angdisen, Jerry; Chan, Shun Hang; Chang, YingJu; Osborne, Timothy F.; Koeppel, Alexander F.; Turner, Stephen D.; Schulman, Ira G.

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization

JOURNAL OF ADVANCED RESEARCH

IF13

2023-03-01

OAAI

Lee, Jae-Ho; Lee, Sun Hee; Lee, Eun-Ho; Cho, Jeong-Yong; Song, Dae-Kyu; Lee, Young Jae; Kwon, Taeg Kyu; Oh, Byung-Chul; Cho, Kae Won; Osborne, Timothy F.; Jeon, Tae-Il; Im, Seung-Soon

Intersection of Trained Immunity and Metabolism in Macrophages Through SETDB2

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-01

OAAI

Jaiswal, Anant; Halasz, Laszlo; Osborne, Timothy

SREBP signaling is essential for effective B cell responses SREBP信号传导对于有效的b细胞反应至关重要

NATURE IMMUNOLOGY

IF27.6

2022-12-28

OAAI

Luo, Wei; Adamska, Julia Z. Z.; Li, Chunfeng; Verma, Rohit; Liu, Qing; Hagan, Thomas; Wimmers, Florian; Gupta, Shakti; Feng, Yupeng; Jiang, Wenxia; Zhou, Jiehao; Valore, Erika; Wang, Yanli; Trisal, Meera; Subramaniam, Shankar; Osborne, Timothy F.; Pulendran, Bali

研究方向