未登录 Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease 脑多组学分析识别阿尔茨海默病中与tau蛋白相关的转录组失调 Stephanie R Oatman, PhD; Zachary S Quicksall, MS; Xue Wang, PhD; Jeremiah Bergman; Joseph S Reddy, PhD; Floor Vanelderen; Thuy Nguyen; Kimberly Malphrus; Sarah J Lincoln; Yuka A Martens, PhD; Na Zhao, PhD; Yu Yamazaki; Michael DeTure, PhD; Melissa E Murray, PhD; Chia-Chen Liu, PhD; Guojun Bu, PhD; Takahisa Kanekiyo, PhD; Dennis W Dickson, MD; Mariet Allen, PhD; Nilüfer Ertekin-Taner, MD PhD 分享 收藏
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The UFMylation pathway is impaired in Alzheimer's disease Yan, Tingxiang; Heckman, Michael G.; Craver, Emily C.; Liu, Chia-Chen; Rawlinson, Bailey D.; Wang, Xue; Murray, Melissa E.; Dickson, Dennis W.; Ertekin-Taner, Nilufer; Lou, Zhenkun; Bu, Guojun; Springer, Wolfdieter; Fiesel, Fabienne C. 分享 收藏
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference APOE和痴呆症研究的进展: 2023 AAIC进展的亮点: APOE会议 Kloske, Courtney M.; Belloy, Michael E.; Blue, Elizabeth E.; Bowman, Gregory R.; Carrillo, Maria C.; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A.; Di Paolo, Gilbert; Garretti, Francesca; Gate, David; Golden, Lesley R.; Heinecke, Jay W.; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A.; Kanekiyo, Takahisa; Karch, Celeste M.; Khvorova, Anastasia; Koppes-den Hertog, Sascha J.; Lamb, Bruce T.; Lawler, Paige E.; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M.; Miller, Justin J.; Morganti, Josh M.; Narayan, Priyanka S.; Naslavsky, Michel S.; Oosthoek, Marlies; Ramachandran, Kapil V.; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N. M.; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J.; Soranno, Andrea; Strickland, Michael R.; Julia, T. C. W.; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A.; Ulrich, Jason D.; van der Kant, Rik; Wang, Na; Wellington, Cheryl L.; Weninger, Stacie C.; Yassine, Hussein N.; Zhao, Na; Bu, Guojun; Goate, Alison M.; Holtzman, David M. 分享 收藏
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease Raulin, Ana-Caroline; Doss, Sydney V.; Heckman, Michael G.; Craver, Emily C.; Li, Zonghua; Ikezu, Tadafumi C.; Sekiya, Hiroaki; Liu, Chia-Chen; Martens, Yuka A.; Rosenberg, Cassandra L.; Kuchenbecker, Lindsey A.; Deture, Michael; Reichard, R. Ross; Nguyen, Aivi T.; Constantopoulos, Eleni; Larsen, Rachel A.; Kounaves, Emmaline K.; Murray, Melissa E.; Dickson, Dennis W.; Petersen, Ronald C.; Bu, Guojun; Kanekiyo, Takahisa 分享 收藏
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease Liu, Chia-Chen; Wang, Na; Chen, Yuanxin; Inoue, Yasuteru; Shue, Francis; Ren, Yingxue; Wang, Minghui; Qiao, Wenhui; Ikezu, Tadafumi C.; Li, Zonghua; Zhao, Jing; Martens, Yuka; Doss, Sydney V.; Rosenberg, Cassandra L.; Jeevaratnam, Suren; Jia, Lin; Raulin, Ana-Caroline; Qi, Fangfang; Zhu, Yiyang; Alnobani, Alla; Knight, Joshua; Chen, Yixing; Linares, Cynthia; Kurti, Aishe; Fryer, John D.; Zhang, Bin; Wu, Long-Jun; Kim, Betty Y. S.; Bu, Guojun 分享 收藏
Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology sFRP1的上调在雌性5xfad小鼠中比雄性更重要，并且与淀粉样蛋白病理呈正相关 Macyczko, Jesse R.; Wang, Na; Lu, Wenyan; Jeevaratnam, Suren; Shue, Francis; Martens, Yuka; Liu, Chia-Chen; Kanekiyo, Takahisa; Bu, Guojun; Li, Yonghe 分享 收藏
Sex specific molecular networks and key drivers of Alzheimer's disease Guo, Lei; Cao, Jiqing; Hou, Jianwei; Li, Yonghe; Huang, Min; Zhu, Li; Zhang, Larry; Lee, Yeji; Duarte, Mariana Lemos; Zhou, Xianxiao; Wang, Minghui; Liu, Chia-Chen; Martens, Yuka; Chao, Michael; Goate, Alison; Bu, Guojun; Haroutunian, Vahram; Cai, Dongming; Zhang, Bin 分享 收藏
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology (vol 18, 8, 2023) Qiao, Wenhui; Chen, Yixing; Zhong, Jun; Madden, Benjamin J.; Charlesworth, Cristine M.; Martens, Yuka A.; Liu, Chia-Chen; Knight, Joshua; Ikezu, Tadafumi C.; Aishe, Kurti; Zhu, Yiyang; Meneses, Axel; Rosenberg, Cassandra L.; Kuchenbecker, Lindsey A.; Vanmaele, Lucy K.; Li, Fuyao; Chen, Kai; Shue, Francis; Dacquel, Maxwell V.; Fryer, John; Pandey, Akhilesh; Zhao, Na; Bu, Guojun 分享 收藏
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 Oue, Hiroshi; Yamazaki, Yu; Qiao, Wenhui; Yuanxin, Chen; Ren, Yingxue; Kurti, Aishe; Shue, Francis; Parsons, Tammee M.; Perkerson, Ralph B.; Kawatani, Keiji; Wang, Ni; Starling, Skylar C.; Roy, Bhaskar; Mosneag, Ioana-Emilia; Aikawa, Tomonori; Holm, Marie-Louise; Liu, Chia-Chen; Inoue, Yasuteru; Sullivan, Patrick M.; Asmann, Yan W.; Kim, Betty Y. S.; Bu, Guojun; Kanekiyo, Takahisa 分享 收藏
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology Trem2 H157Y增加可溶性TREM2的产生并减少淀粉样蛋白病理 Qiao, Wenhui; Chen, Yixing; Zhong, Jun; Madden, Benjamin J.; Charlesworth, Cristine M.; Martens, Yuka A.; Liu, Chia-Chen; Knight, Joshua; Ikezu, Tadafumi C.; Aishe, Kurti; Zhu, Yiyang; Meneses, Axel; Rosenberg, Cassandra L.; Kuchenbecker, Lindsey A.; Vanmaele, Lucy K.; Li, Fuyao; Chen, Kai; Shue, Francis; Dacquel, Maxwell V.; Fryer, John; Pandey, Akhilesh; Zhao, Na; Bu, Guojun 分享 收藏
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins 大脑生化表型的全基因组关联研究揭示了阿尔茨海默病相关蛋白的独特遗传结构 Oatman, Stephanie R.; Reddy, Joseph S.; Quicksall, Zachary; Carrasquillo, Minerva M.; Wang, Xue; Liu, Chia-Chen; Yamazaki, Yu; Nguyen, Thuy T.; Malphrus, Kimberly; Heckman, Michael; Biswas, Kristi; Nho, Kwangsik; Baker, Matthew; Martens, Yuka A.; Zhao, Na; Kim, Jun Pyo; Risacher, Shannon L.; Rademakers, Rosa; Saykin, Andrew J.; DeTure, Michael; Murray, Melissa E.; Kanekiyo, Takahisa; Dickson, Dennis W.; Bu, Guojun; Allen, Mariet; Ertekin-Taner, Niluefer 分享 收藏
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Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination Wang, Na; Wang, Minghui; Jeevaratnam, Suren; Rosenberg, Cassandra; Ikezu, Tadafumi C.; Shue, Francis; Doss, Sydney, V; Alnobani, Alla; Martens, Yuka A.; Wren, Melissa; Asmann, Yan W.; Zhang, Bin; Bu, Guojun; Liu, Chia-Chen 分享 收藏
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Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia Zhao, Na; Qiao, Wenhui; Li, Fuyao; Ren, Yingxue; Zheng, Jiaying; Martens, Yuka A.; Wang, Xusheng; Li, Ling; Liu, Chia-Chen; Chen, Kai; Zhu, Yiyang; Ikezu, Tadafumi C.; Li, Zonghua; Meneses, Axel D.; Jin, Yunjung; Knight, Joshua A.; Chen, Yixing; Bastea, Ligia; Linares, Cynthia; Sonustun, Berkiye; Job, Lucy; Smith, Madeleine L.; Xie, Manling; Liu, Yong U.; Umpierre, Anthony D.; Haruwaka, Koichiro; Quicksall, Zachary S.; Storz, Peter; Asmann, Yan W.; Wu, Long-Jun; Bu, Guojun 分享 收藏
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