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Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease Tanaka, Atsushi; Maeda, Shinji; Nomura, Takashi; Llamas-Covarrubias, Mara Anais; Tanaka, Satoshi; Jin, Lin; Lim, Ee Lyn; Morikawa, Hiromasa; Kitagawa, Yohko; Akizuki, Shuji; Ito, Yoshinaga; Fujimori, Chihiro; Hirota, Keiji; Murase, Tosei; Hashimoto, Motomu; Higo, Junichi; Zamoyska, Rose; Ueda, Ryuzo; Standley, Daron M. M.; Sakaguchi, Noriko; Sakaguchi, Shimon 分享 收藏
Characterization of human epithelial resident memory regulatory T cells Sato, Takuya; Ogawa, Youichi; Yokoi, Kazunori; Nagasaka, Yuka; Ishikawa, Aoha; Shiokawa, Ichiro; Kinoshita, Manao; Watanabe, Rei; Shimada, Shinji; Tanaka, Atsushi; Momosawa, Akira; Kawamura, Tatsuyoshi 分享 收藏
PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment 炎性肿瘤微环境中PGE2-EP2/EP4信号通过驱动mregdc-treg轴引发免疫抑制 Thumkeo, Dean; Punyawatthananukool, Siwakorn; Prasongtanakij, Somsak; Matsuura, Ryuma; Arima, Kentaro; Nie, Huan; Yamamoto, Rie; Aoyama, Naohiro; Hamaguchi, Hisao; Sugahara, Shingo; Takeda, Shinobu; Charoensawan, Varodom; Tanaka, Atsushi; Sakaguchi, Shimon; Narumiya, Shuh 分享 收藏
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory 肿瘤组织中克隆扩增的Treg细胞的CCR8-targeted特异性耗竭引起具有持久记忆的有效肿瘤免疫 Kidani, Yujiro; Nogami, Wataru; Yasumizu, Yoshiaki; Kawashima, Atsunari; Tanaka, Atsushi; Sonoda, Yudai; Tona, Yumi; Nashiki, Kunitaka; Matsumoto, Reimi; Hagiwara, Masaki; Osaki, Motonao; Dohi, Keiji; Kanazawa, Takayuki; Ueyama, Azumi; Yoshikawa, Mai; Yoshida, Tetsuya; Matsumoto, Mitsunobu; Hojo, Kanji; Shinonome, Satomi; Yoshida, Hiroshi; Hirata, Michinari; Haruna, Miya; Nakamura, Yamami; Motooka, Daisuke; Okuzaki, Daisuke; Sugiyama, Yasuko; Kinoshita, Makoto; Okuno, Tatsusada; Kato, Taigo; Hatano, Koji; Uemura, Motohide; Imamura, Ryoichi; Yokoi, Kazunori; Tanemura, Atsushi; Shintani, Yasushi; Kimura, Tadashi; Nonomura, Norio; Wada, Hisashi; Mori, Masaki; Doki, Yuichiro; Ohkura, Naganari; Sakaguchi, Shimon 分享 收藏
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Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells Tanaka, Atsushi; Nishikawa, Hiroyoshi; Noguchi, Shinsuke; Sugiyama, Daisuke; Morikawa, Hiromasa; Takeuchi, Yoshiko; Ha, Danbee; Shigeta, Naoya; Kitawaki, Toshio; Maeda, Yuka; Saito, Takuro; Shinohara, Yoshinori; Kameoka, Yoshihiro; Iwaisako, Keiko; Monma, Fumihiko; Ohishi, Kohshi; Karbach, Julia; Jaeger, Elke; Sawada, Kenichi; Katayama, Naoyuki; Takahashi, Naoto; Sakaguchi, Shimon 分享 收藏
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer 通过PD-1阻断扩增的PD-1调节性T细胞促进癌症的过度进展 Kamada, Takahiro; Togashi, Yosuke; Tay, Christopher; Ha, Danbee; Sasaki, Akinori; Nakamura, Yoshiaki; Sato, Eiichi; Fukuoka, Shota; Tada, Yasuko; Tanaka, Atsushi; Morikawa, Hiromasa; Kawazoe, Akihito; Kinoshita, Takahiro; Shitara, Kohei; Sakaguchi, Shimon; Nishikawa, Hiroyoshi 分享 收藏
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Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody Fc工程anti-CTLA-4抗体对人Treg和效应T细胞在肿瘤免疫中的差异控制 Ha, Danbee; Tanaka, Atsushi; Kibayashi, Tatsuya; Tanemura, Atsushi; Sugiyama, Daisuke; Wing, James Badger; Lim, Ee Lyn; Teng, Karen Wei Weng; Adeegbe, Dennis; Newell, Evan W.; Katayama, Ichiro; Nishikawa, Hiroyoshi; Sakaguchi, Shimon 分享 收藏
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis Hirota, Keiji; Hashimoto, Motomu; Ito, Yoshinaga; Matsuura, Mayumi; Ito, Hiromu; Tanaka, Masao; Watanabe, Hitomi; Kondoh, Gen; Tanaka, Atsushi; Yasuda, Keiko; Kopf, Manfred; Potocnik, Alexandre J.; Stockinger, Brigitta; Sakaguchi, Noriko; Sakaguchi, Shimon 分享 收藏
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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) Leverson, J. D.; Zhang, H.; Chen, J.; Tahir, S. K.; Phillips, D. C.; Xue, J.; Nimmer, P.; Jin, S.; Smith, M.; Xiao, Y.; Kovar, P.; Tanaka, A.; Bruncko, M.; Sheppard, G. S.; Wang, L.; Gierke, S.; Kategaya, L.; Anderson, D. J.; Wong, C.; Eastham-Anderson, J.; Ludlam, M. J. C.; Sampath, D.; Fairbrother, W. J.; Wertz, I.; Rosenberg, S. H.; Tse, C.; Elmore, S. W.; Souers, A. J. 分享 收藏
T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development Ohkura, Naganari; Hamaguchi, Masahide; Morikawa, Hiromasa; Sugimura, Kyoko; Tanaka, Atsushi; Ito, Yoshinaga; Osaki, Motonao; Tanaka, Yoshiaki; Yamashita, Riu; Nakano, Naoko; Huehn, Jochen; Fehling, Hans Joerg; Sparwasser, Tim; Nakai, Kenta; Sakaguchi, Shimon 分享 收藏
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