Daan M. F. van Aalten - Publications, H-index & Citations

Daan M. F. van Aalten

University of Naples Federico II

73H指数

377论文数

2.2W被引数

收录论文 100

发表时间

Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms 多域o-glcnacase结构揭示了变构调控机制

Nature Communications

IF15.7

2025-10-03

OAAI

Sara Basse Hansen; Sergio G. Bartual; Huijie Yuan; Olawale G. Raimi; Andrii Gorelik; Andrew T. Ferenbach; Kristian Lytje; Jan Skov Pedersen; Taner Drace; Thomas Boesen; Daan M. F. van Aalten

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma 一名患有严重发育迟缓和肝母细胞瘤的儿童中，存在一种OGT错义变异，其酶活性受损。

AMERICAN JOURNAL OF MEDICAL GENETICS PART A

IF1.7

2025-10-01

OAAI

D'Alessio, Alfonso Manuel; Yuan, Huijie; Soria, Leandro Raul; Hansen, Sara Basse; Boffa, Iolanda; Arena, Paola; Attianese, Benedetta; O'Sullivan, Maureen.; Cullinan, Noelle; Pang, Lewis; van Aalten, Daan Marinus Ferdinand; Brunetti-Pierri, Nicola; Lynch, Sally Ann

Zscan4 as a candidate conveyor of early developmental defects in O-GlcNAc transferase intellectual disability Zscan4 作为 O-GlcNAc 转移酶智力障碍早期发育缺陷的候选传导者

Molecular & Cellular Proteomics

IF5.5

2025-09-29

OAAI

Veronica M. Pravata; Hao Jiang; Andrew T. Ferenbach; Angus Lamond; Daan M.F. van Aalten

Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence Gfa1（谷氨酰胺果糖-6-磷酸氨基转移酶）对于烟曲霉的生长和毒力至关重要。

BMC BIOLOGY

IF4.5

2025-03-13

OAAI

Qin, Qijian; Wei, Pingzhen; Usman, Sayed; Ahamefule, Chukwuemeka Samson; Jin, Cheng; Wang, Bin; Yan, Kaizhou; van Aalten, Daan M. F.; Fang, Wenxia

Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants

STEM CELL REPORTS

IF5.1

2025-01-01

OAAI

Yuan, Huijie; Mitchell, Conor W.; Ferenbach, Andrew T.; Bonati, Maria Teresa; Feresin, Agnese; Benke, Paul J.; Tan, Queenie K. G.; van Aalten, Daan M. F.

O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-09-01

OAAI

May, Johnathan M.; Hitefiled, Naomi L.; Czajewski, Ignacy; Vanhye, Lotte; Holden, Laura; Morava, Eva; van Aalten, Daan M. F.; Wells, Lance

Neuroectoderm phenotypes in a human stem cell model of O-GlcNAc transferase associated with intellectual disability

MOLECULAR GENETICS AND METABOLISM

IF3.5

2024-06-01

OAAI

Murray, Marta; Davidson, Lindsay; Ferenbach, Andrew T.; Lefeber, Dirk; van Aalten, Daan M. F.

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

DISEASE MODELS & MECHANISMS

IF3.3

2024-04-25

OAAI

Authier, Florence; Ondruskova, Nina; Ferenbach, Andrew T.; Mcneilly, Alison D.; van Aalten, Daan M. F.

Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning

ELIFE

IF0

2024-04-15

OAAI

Yu, Haibin; Liu, Dandan; Zhang, Yaowen; Tang, Ruijun; Fan, Xunan; Mao, Song; Lv, Lu; Chen, Fang; Qin, Hongtao; Zhang, Zhuohua; van Alten, Daan M. F.; Yang, Bing; Yuan, Kai

Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis

JOURNAL OF GENETICS AND GENOMICS

IF7.1

2023-12-01

OAAI

Zhang, Yaowen; Yu, Haibin; Wang, Dandan; Lei, Xiaoyun; Meng, Yang; Zhang, Na; Chen, Fang; Lv, Lu; Pan, Qian; Qin, Hongtao; Zhang, Zhuohua; van Aalten, Daan M. F.; Yuan, Kai

Lateral interactions govern self-assembly of the bacterial biofilm matrix BslA 横向相互作用控制细菌生物膜基质BslA的自组装

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-10-30

OAAI

Arnaouteli, Sofia; Bamford, Natalie C.; Brandani, Giovanni B.; Morris, Ryan J.; Schor, Marieke; Carrington, Jamie T.; Hobley, Laura; van Aalten, Daan M. F.; Stanley-Wall, Nicola R.; MacPhee, Cait E.

Exploiting O-GlcNAc transferase promiscuity to dissect site-specific O-GlcNAcylation 利用o-glcnac转移酶的混杂性来分解位点特异性o-glcnacylation

GLYCOBIOLOGY

IF3.3

2023-10-19

OAAI

Mitchell, Conor W.; Galan Bartual, Sergio; Ferenbach, Andrew T.; Scavenius, Carsten; van Aalten, Daan M. F.

An O-GlcNAc transferase pathogenic variant linked to intellectual disability affects pluripotent stem cell self-renewal

DISEASE MODELS & MECHANISMS

IF3.3

2023-06-19

OAAI

Omelkova, Michaela; Fenger, Christina Duhring; Murray, Marta; Hammer, Trine Bjorg; Pravata, Veronica M.; Bartuai, Sergio Galan; Czajewski, Ignacy; Bayat, Allan; Ferenbach, Andrew T.; Stavridis, Marios P.; van Aalten, Daan M. F.

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance PDK1 PH结构域的突变抑制蛋白激酶B/Akt，导致小尺寸和胰岛素抵抗

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

126

OAAI

Bayascas, Jose R.; Wullschleger, Stephan; Sakamoto, Kei; Garcia-Martinez, Juan M.; Clacher, Carol; Komander, David; van Aalten, Daan M. F.; Boini, Krishna M.; Lan, Florian; Lipina, Christopher; Logie, Lisa; Sutherland, Calum; Chudek, John A.; van Diepen, Janna A.; Voshol, Peter J.; Lucocq, John M.; Alessi, Dario R.

The role of O-GlcNAcylation in development

DEVELOPMENT

IF3.6

2023-03-16

OAAI

Czajewski, Ignacy; van Aalten, Daan M. F.

The active site of O-GlcNAc transferase imposes constraints on substrate sequence (vol 22, pg 744, 2015)

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2023-03-03

OAAI

Pathak, Shalini; Alonso, Jana; Schimpl, Marianne; Rafie, Karim; Blair, David E. E.; Borodkin, Vladimir S. S.; Schuettelkopf, Alexander W. W.; Albarbarawi, Osama; van Aalten, Daan M. F.

O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis

NATURE COMMUNICATIONS

IF15.7

2022-09-05

OAAI

Soria, Leandro R.; Makris, Georgios; D'Alessio, Alfonso M.; De Angelis, Angela; Boffa, Iolanda; Pravata, Veronica M.; Rufenacht, Veronique; Attanasio, Sergio; Nusco, Edoardo; Arena, Paola; Ferenbach, Andrew T.; Paris, Debora; Cuomo, Paola; Motta, Andrea; Nitzahn, Matthew; Lipshutz, Gerald S.; Martinez-Pizarro, Ainhoa; Richard, Eva; Desviat, Lourdes R.; Haeberle, Johannes; van Aalten, Daan M. F.; Brunetti-Pierri, Nicola

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-09-01

OAAI

Mitchell, Conor W.; Czajewski, Ignacy; Aalten, Daan M. F. van

Phosphoglucose Isomerase Is Important for Aspergillus fumigatus Cell Wall Biogenesis

MBIO

IF4.7

2022-08-30

OAAI

Zhou, Yao; Yan, Kaizhou; Qin, Qijian; Raimi, Olawale G.; Du, Chao; Wang, Bin; Ahamefule, Chukwuemeka Samson; Kowalski, Bartosz; Jin, Cheng; van Aalten, Daan M. F.; Fang, Wenxia

Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-06-01

OAAI

Yan, Kaizhou; Stanley, Mathew; Kowalski, Bartosz; Raimi, Olawale G.; Ferenbach, Andrew T.; Wei, Pingzhen; Fang, Wenxia; van Aalten, Daan M. F.

研究方向