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收藏分享 收藏 Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity
Sato, Naru; Goyama, Susumu; Chang, Yu-Hsuan; Miyawaki, Masashi; Fujino, Takeshi; Koide, Shuhei; Denda, Tamami; Liu, Xiaoxiao; Ueda, Koji; Yamamoto, Keita; Asada, Shuhei; Takeda, Reina; Yonezawa, Taishi; Tanaka, Yosuke; Honda, Hiroaki; Ota, Yasunori; Shibata, Takuma; Sekiya, Motohiro; Isobe, Tomoya; Lamagna, Chrystelle; Masuda, Esteban; Iwama, Atsushi; Shimano, Hitoshi; Inoue, Jun-ichiro; Miyake, Kensuke; Kitamura, Toshio 分享 收藏 分享 收藏 TLR7/8 stress response drives histiocytosis in SLC29A3 disordersTLR7/8应激反应驱动SLC29A3疾病中的组织细胞增生症Shibata, Takuma; Sato, Ryota; Taoka, Masato; Saitoh, Shin-Ichiroh; Komine, Mayumi; Yamaguchi, Kiyoshi; Goyama, Susumu; Motoi, Yuji; Kitaura, Jiro; Izawa, Kumi; Yamauchi, Yoshio; Tsukamoto, Yumiko; Ichinohe, Takeshi; Fujita, Etsuko; Hiranuma, Ryosuke; Fukui, Ryutaro; Furukawa, Yoichi; Kitamura, Toshio; Takai, Toshiyuki; Tojo, Arinobu; Ohtsuki, Mamitaro; Ohto, Umeharu; Shimizu, Toshiyuki; Ozawa, Manabu; Yoshida, Nobuaki; Isobe, Toshiaki; Latz, Eicke; Mukai, Kojiro; Taguchi, Tomohiko; Hemmi, Hiroaki; Akira, Shizuo; Miyake, Kensuke 分享 收藏 TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transductionTLR3沿着双链RNA形成横向排列的多聚体复合物，用于有效的信号转导Sakaniwa, Kentaro; Fujimura, Akiko; Shibata, Takuma; Shigematsu, Hideki; Ekimoto, Toru; Yamamoto, Masaki; Ikeguchi, Mitsunori; Miyake, Kensuke; Ohto, Umeharu; Shimizu, Toshiyuki 分享 收藏 IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia抑制IMPDH激活TLR-VCAM1通路并抑制MLL融合白血病的发展Liu, Xiaoxiao; Sato, Naru; Yabushita, Tomohiro; Li, Jingmei; Jia, Yuhan; Tamura, Moe; Asada, Shuhei; Fujino, Takeshi; Fukushima, Tsuyoshi; Yonezawa, Taishi; Tanaka, Yosuke; Fukuyama, Tomofusa; Tsuchiya, Akiho; Shikata, Shiori; Iwamura, Hiroyuki; Kinouchi, Chieko; Komatsu, Kensuke; Yamasaki, Satoshi; Shibata, Tatsuhiro; Sasaki, Atsuo T.; Schibler, Janet; Wunderlich, Mark; O'Brien, Eric; Mizukawa, Benjamin; Mulloy, James C.; Sugiura, Yuki; Takizawa, Hitoshi; Shibata, Takuma; Miyake, Kensuke; Kitamura, Toshio; Goyama, Susumu 分享 收藏 分享 收藏 Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1孤儿转运蛋白SLC35E1在单纯疱疹病毒1核出口中的作用Maeda, Fumio; Kato, Akihisa; Takeshima, Kosuke; Shibazaki, Misato; Sato, Ryota; Shibata, Takuma; Miyake, Kensuke; Kozuka-Hata, Hiroko; Oyama, Masaaki; Shimizu, Eigo; Imoto, Seiya; Miyano, Satoru; Adachi, Shungo; Natsume, Tohru; Takeuchi, Koh; Maruzuru, Yuhei; Koyanagi, Naoto; Jun, Arii; Yasushi, Kawaguchi 分享 收藏 Structural analysis reveals TLR7 dynamics underlying antagonism结构分析揭示TLR7动力学潜在的拮抗作用Tojo, Shingo; Zhang, Zhikuan; Matsui, Hiroyuki; Tahara, Masahiro; Ikeguchi, Mitsunori; Kochi, Mami; Kamada, Mami; Shigematsu, Hideki; Tsutsumi, Akihisa; Adachi, Naruhiko; Shibata, Takuma; Yamamoto, Masaki; Kikkawa, Masahide; Senda, Toshiya; Isobe, Yoshiaki; Ohto, Umeharu; Shimizu, Toshiyuki 分享 收藏 Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-Like Receptor 7/Interleukin-33 Signaling活化的M2巨噬细胞通过Toll样受体7/Interleukin-33信号参与IgG4-Related疾病的发病机制Ishiguro, Noriko; Moriyama, Masafumi; Furusho, Katsuhiro; Furukawa, Sachiko; Shibata, Takuma; Murakami, Yusuke; Chinju, Akira; Haque, A. S. M. Rafiul; Gion, Yuka; Ohta, Miho; Maehara, Takashi; Tanaka, Akihiko; Yamauchi, Masaki; Sakamoto, Mizuki; Mochizuki, Keita; Ono, Yuko; Hayashida, Jun-Nosuke; Sato, Yasuharu; Kiyoshima, Tamotsu; Yamamoto, Hidetaka; Miyake, Kensuke; Nakamura, Seiji 分享 收藏 分享 收藏 Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic LigandsToll样受体7的结构分析揭示了激动性配体的详细RNA序列特异性和识别机制Zhang, Zhikuan; Ohto, Umeharu; Shibata, Takuma; Taoka, Masato; Yamauchi, Yoshio; Sato, Ryota; Shukla, Nikunj M.; David, Sunil A.; Isobe, Toshiaki; Miyake, Kensuke; Shimizu, Toshiyuki 分享 收藏 Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis通过增强TLR3-mTORC2轴来对抗疱疹病毒性脑炎Sato, Ryota; Kato, Akihisa; Chimura, Takahiko; Saitoh, Shin-Ichiroh; Shibata, Takuma; Murakami, Yusuke; Fukui, Ryutaro; Liu, Kaiwen; Zhang, Yun; Arii, Jun; Sun-Wada, Ge-Hong; Wada, Yoh; Ikenoue, Tsuneo; Barber, Glen N.; Manabe, Toshiya; Kawaguchi, Yasushi; Miyake, Kensuke 分享 收藏 分享 收藏 Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA体内对单链DNA的反应需要Toll样受体9胞外域的切割Fukui, Ryutaro; Yamamoto, Chikako; Matsumoto, Fumi; Onji, Masahiro; Shibata, Takuma; Murakami, Yusuke; Kanno, Atsuo; Hayashi, Takuto; Tanimura, Natsuko; Yoshida, Nobuaki; Miyake, Kensuke 分享 收藏 分享 收藏 Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy编码内质网伴侣的CNPY3中的双等位基因变体导致早发性癫痫性脑病Mutoh, Hiroki; Kato, Mitsuhiro; Akita, Tenpei; Shibata, Takuma; Wakamoto, Hiroyuki; Ikeda, Hiroko; Kitaura, Hiroki; Aoto, Kazushi; Nakashima, Mitsuko; Wang, Tianying; Ohba, Chihiro; Miyatake, Satoko; Miyake, Noriko; Kakita, Akiyoshi; Miyake, Kensuke; Fukuda, Atsuo; Matsumoto, Naomichi; Saitsu, Hirotomo 分享 收藏 Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production上皮膜蛋白3 (Emp3) 通过产生tnf-α 下调巨噬细胞对细胞毒性T淋巴细胞的诱导和功能Kusumoto, Yutaka; Okuyama, Hiromi; Shibata, Takuma; Konno, Kazunori; Takemoto, Yusuke; Maekawa, Daisuke; Kononaga, Tomoyuki; Ishii, Takashi; Akashi-Takamura, Sachiko; Saitoh, Shin-ichiroh; Ikebuchi, Ryoyo; Moriya, Taiki; Ueda, Mizuki; Miyake, Kensuke; Ono, Shiro; Tomura, Michio 分享 收藏 Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation携带癌症特异性FBXW7突变的条件性敲入等位基因的新小鼠系的建立和分析Ikenoue, Tsuneo; Terakado, Yumi; Zhu, Chi; Liu, Xun; Ohsugi, Tomoyuki; Matsubara, Daisuke; Fujii, Tomoki; Kakuta, Shigeru; Kubo, Sachiko; Shibata, Takuma; Yamaguchi, Kiyoshi; Iwakura, Yoichiro; Furukawa, Yoichi 分享 收藏 
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