未登录Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn mice
Hirani, Dharmesh; Selle, Jaco; Wagde, Virta; Klymenko, Oleksiy; Kuiper-Makris, Celien; Danopoulos, Soula; Donato, Michele; Preuss, Stefanie; Preuss, Mark; Mujahid, Sana; Vohlen, Christina; Wulf, Kerstin; Van Koningsbruggen-Rietschel, Silke; Khatri, Purvesh; Wunderlich, Thomas; Koch, Manuel; Rose-John, Stefan; Sucre, Jennifer M. S.; Al-Alam, Denise; Seeger, Werner; Dotsch, Jorg; Bland, Richard D.; Rabinovitch, Marlene; Alcazar, Miguel A. Alejandre .png)
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收藏Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma雷帕霉素抵抗性多克隆Th1/Tc1细胞疗法（RAPA-201）安全地诱导复发、难治性多发性骨髓瘤的疾病缓解。Dhakal, Binod; Hari, Parameswaran; Chhabra, Saurabh; Szabo, Aniko; Lum, Lawrence G.; Glass, Deborah D.; Park, Jee Hyun; Donato, Michele; Siegel, David S.; Felizardo, Tania C.; Fowler, Daniel H. 分享 收藏 IL6-ET1 signaling inhibits alveolar growth through FoxO1-dependent AT2 survival in mechanically ventilated newborn miceKuiper-Makris, Centina; Hirani, Dharmesh; Wagde, Virta; Selle, Jaco; Klymenko, Oleksiy; Donato, Michele; Preuss, Stefanie; Kaschwich, Mark; Mujahid, Sana; Vohlen, Christina; Wilke, Rebecca; Wulf, Kerstin; Van-Koningsbruggen-Rietschel, Silke; Khatri, Parvesh; Koch, Manuel; Rose-John, Stefan; Seeger, Werner; Doetsch, Jorg; Bland, Richard D.; Rabinovitch, Marlene; Alcazar, Miguel Angel Alejandre 分享 收藏 Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells疟疾的临床免疫涉及先天免疫细胞的表观遗传重编程Nideffer, Jason; Ty, Maureen; Donato, Michele; John, Rek; Kajubi, Richard; Ji, Xuhuai; Nankya, Felistas; Musinguzi, Kenneth; Press, Kathleen Dantzler; Yang, Nora; Camanag, Kylie; Greenhouse, Bryan; Kamya, Moses; Feeney, Margaret E.; Dorsey, Grant; Utz, Paul J.; Pulendran, Bali; Khatri, Purvesh; Jagannathan, Prasanna 分享 收藏 Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humansRatnasiri, Kalani; Zheng, Hong; Toh, Jiaying; Yao, Zhiyuan; Duran, Veronica; Donato, Michele; Roederer, Mario; Kamath, Megha; Todd, John-Paul M.; Gagne, Matthew; Foulds, Kathryn E.; Francica, Joseph R.; Corbett, Kizzmekia S.; Douek, Daniel C.; Seder, Robert A.; Einav, Shirit; Blish, Catherine A.; Khatri, Purvesh 分享 收藏 Ancestry-based differences in the immune phenotype are associated with lupus activitySlight-Webb, Samantha; Thomas, Kevin; Smith, Miles; Wagner, Catriona A.; Macwana, Susan; Bylinska, Aleksandra; Donato, Michele; Dvorak, Mai; Chang, Sarah E.; Kuo, Alex; Cheung, Peggie; Kalesinskas, Laurynas; Ganesan, Ananthakrishnan; Dermadi, Denis; Guthridge, Carla J.; Dejager, Wade; Wright, Christian; Foecke, Mariko H.; Merrill, Joan T.; Chakravarty, Eliza; Arriens, Cristina; Maecker, Holden T.; Khatri, Purvesh; Utz, Paul J.; James, Judith A.; Guthridge, Joel M. 分享 收藏 Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malariaTy, Maureen; Sun, Shenghuan; Callaway, Perri C.; Rek, John; Press, Kathleen D.; van der Ploeg, Kattria; Nideffer, Jason; Hu, Zicheng; Klemm, Sandy; Greenleaf, William; Donato, Michele; Tukwasibwe, Stephen; Arinaitwe, Emmanuel; Nankya, Felistas; Musinguzi, Kenneth; Andrew, Dean; de la Parte, Lauren; Mori, Diego Martinez; Lewis, Savannah N.; Takahashi, Saki; Rodriguez-Barraquer, Isabel; Greenhouse, Bryan; Blish, Catherine; Utz, P. J.; Khatri, Purvesh; Dorsey, Grant; Kamya, Moses; Boyle, Michelle; Feeney, Margaret; Ssewanyana, Isaac; Jagannathan, Prasanna 分享 收藏 Mass-Cytometry-Based Quantification of Global Histone Post-Translational Modifications at Single-Cell Resolution Across Peripheral Immune Cells in IBDBai, Lawrence; Dermadi, Denis; Kalesinskas, Laurynas; Dvorak, Mai; Chang, Sarah E.; Ganesan, Ananthakrishnan; Rubin, Samuel J. S.; Kuo, Alex; Cheung, Peggie; Donato, Michele; Utz, Paul J.; Habtezion, Aida; Khatri, Purvesh 分享 收藏 Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infectionBohrer, Andrea C.; Castro, Ehydel; Tocheny, Claire E.; Assmann, Maike; Schwarz, Benjamin; Bohrnsen, Eric; Makiya, Michelle A.; Legrand, Fanny; Hilligan, Kerry L.; Baker, Paul J.; Torres-Juarez, Flor; Hu, Zhidong; Ma, Hui; Wang, Lin; Niu, Liangfei; Wen, Zilu; Lee, Sang H.; Kamenyeva, Olena; Kauffman, Keith D.; Donato, Michele; Sher, Alan; Barber, Daniel L.; Via, Laura E.; Scriba, Thomas J.; Khatri, Purvesh; Song, Yanzheng; Wong, Ka-Wing; Bosio, Catharine M.; Klion, Amy D.; Mayer-Barber, Katrin D. 分享 收藏 The immunoregulatory landscape of human tuberculosis granulomas (vol 23, pg 318, 2022)McCaffrey, Erin F.; Donato, Michele; Keren, Leeat; Chen, Zhenghao; Delmastro, Alea; Fitzpatrick, Megan B.; Gupta, Sanjana; Greenwald, Noah F.; Baranski, Alex; Graf, William; Kumar, Rashmi; Bosse, Marc; Fullaway, Christine Camacho; Ramdial, Pratista K.; Forgo, Erna; Jojic, Vladimir; Van Valen, David; Mehra, Smriti; Khader, Shabaana A.; Bendall, Sean C.; van de Rijn, Matt; Kalman, Daniel; Kaushal, Deepak; Hunter, Robert L.; Banaei, Niaz; Steyn, Adrie J. C.; Khatri, Purvesh; Angelo, Michael 分享 收藏 The immunoregulatory landscape of human tuberculosis granulomasMcCaffrey, Erin F.; Donato, Michele; Keren, Leeat; Chen, Zhenghao; Delmastro, Alea; Fitzpatrick, Megan B.; Gupta, Sanjana; Greenwald, Noah F.; Baranski, Alex; Graf, William; Kumar, Rashmi; Bosse, Marc; Fullaway, Christine Camacho; Ramdial, Pratista K.; Forgo, Erna; Jojic, Vladimir; Van Valen, David; Mehra, Smriti; Khader, Shabaana A.; Bendall, Sean C.; van de Rijn, Matt; Kalman, Daniel; Kaushal, Deepak; Hunter, Robert L.; Banaei, Niaz; Steyn, Adrie J. C.; Khatri, Purvesh; Angelo, Michael 分享 收藏 A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infectionsButurovic, Ljubomir; Zheng, Hong; Tang, Benjamin; Lai, Kevin; Kuan, Win Sen; Gillett, Mark; Santram, Rahul; Shojaei, Maryam; Almansa, Raquel; Nieto, Jose Angel; Munoz, Sonsoles; Herrero, Carmen; Antonakos, Nikolaos; Koufargyris, Panayiotis; Kontogiorgi, Marina; Damoraki, Georgia; Liesenfeld, Oliver; Wacker, James; Midic, Uros; Luethy, Roland; Rawling, David; Remmel, Melissa; Coyle, Sabrina; Liu, Yiran E.; Rao, Aditya M.; Dermadi, Denis; Toh, Jiaying; Jones, Lara Murphy; Donato, Michele; Khatri, Purvesh; Giamarellos-Bourboulis, Evangelos J.; Sweeney, Timothy E. 分享 收藏 Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasiaHirani, Dharmesh; Alvira, Cristina M.; Danopoulos, Soula; Milla, Carlos; Donato, Michele; Tian, Lu; Mohr, Jasmine; Dinger, Katharina; Vohlen, Christina; Selle, Jaco; Koningsbruggen-Rietschel, Silke, V; Barbarino, Verena; Pallasch, Christian; Rose-John, Stefan; Odenthal, Margarete; Pryhuber, Gloria S.; Mansouri, Siavash; Savai, Rajkumar; Seeger, Werner; Khatri, Purvesh; Al Alam, Denise; Doetsch, Joerg; Alcazar, Miguel A. Alejandre 分享 收藏 Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiationCheung, Peggie; Schaffert, Steven; Chang, Sarah E.; Dvorak, Mai; Donato, Michele; Macaubas, Claudia; Foecke, Mariko H.; Li, Tie-Mei; Zhang, Lichao; Coan, John P.; Schulert, Grant S.; Grom, Alexei A.; Henderson, Lauren A.; Nigrovic, Peter A.; Elias, Joshua E.; Gozani, Or; Mellins, Elizabeth D.; Khatri, Purvesh; Utz, Paul J.; Kuo, Alex J. 分享 收藏 iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertensionGu, Mingxia; Donato, Michele; Guo, Minzhe; Wary, Neil; Miao, Yifei; Mao, Shuai; Saito, Toshie; Otsuki, Shoichiro; Wang, Lingli; Harper, Rebecca L.; Sa, Silin; Khatri, Purvesh; Rabinovitch, Marlene 分享 收藏 Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across virusesZheng, Hong; Rao, Aditya M.; Dermadi, Denis; Toh, Jiaying; Jones, Lara Murphy; Donato, Michele; Liu, Yiran; Su, Yapeng; Dai, Cheng L.; Kornilov, Sergey A.; Karagiannis, Minas; Marantos, Theodoros; Hasin-Brumshtein, Yehudit; He, Yudong D.; Giamarellos-Bourboulis, Evangelos J.; Heath, James R.; Khatri, Purvesh 分享 收藏 Cellular senescence impairs the reversibility of pulmonary arterial hypertensionvan der Feen, Diederik E.; Bossers, Guido P. L.; Hagdorn, Quint A. J.; Moonen, Jan-Renier; Kurakula, Kondababu; Szulcek, Robert; Chappell, James; Vallania, Francesco; Donato, Michele; Kok, Klaas; Kohli, Jaskaren S.; Petersen, Arjen H.; van Leusden, Tom; Demaria, Marco; Goumans, Marie-Jose T. H.; De Boer, Rudolf A.; Khatri, Purvesh; Rabinovitch, Marlene; Berger, Rolf M. F.; Bartelds, Beatrijs 分享 收藏 分享 收藏 FHIT, a Novel Modifier Gene in Pulmonary Arterial HypertensionProsseda, Svenja Dannewitz; Tian, Xuefei; Kuramoto, Kazuya; Boehm, Mario; Sudheendra, Deepti; Miyagawa, Kazuya; Zhang, Fan; Solow-Cordero, David; Saldivar, Joshua C.; Austin, Eric D.; Loyd, James E.; Wheeler, Lisa; Andruska, Adam; Donato, Michele; Wang, Lingli; Huebner, Kay; Metzger, Ross J.; Khatri, Purvesh; Spiekerkoetter, Edda 分享 收藏 Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters跨多个数据集的细菌性败血症转录组学的无监督分析揭示了三个强大的集群Sweeney, Timothy E.; Azad, Tej D.; Donato, Michele; Haynes, Winston A.; Perumal, Thanneer M.; Henao, Ricardo; Bermejo-Martin, Jesus F.; Almansa, Raquel; Tamayo, Eduardo; Howrylak, Judith A.; Choi, Augustine; Parnell, Grant P.; Tang, Benjamin; Nichols, Marshall; Woods, Christopher W.; Ginsburg, Geoffrey S.; Kingsmore, Stephen F.; Omberg, Larsson; Mangravite, Lara M.; Wong, Hector R.; Tsalik, Ephraim L.; Langley, Raymond J.; Khatri, Purvesh 分享 收藏 
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