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F

Frank N. van Leeuwen

princess maxima center for pediatric oncology
H指数:51
被引数:1.0万

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荣誉奖项

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Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4-mediated cell death in TP53-deficient ALL

联合抑制嘧啶的从头合成和ATR促进TP53-deficient ALL的ATF4-mediated细胞死亡

HemaSphere
IF14.6
2026-07-280
OAAI
Kari J. T. Grünewald; Marjolein M. G. Kes; Gawin R. Stoll; Willem P. J. Cox; Dorette S. van Ingen Schenau; Enzo M. Scutigliani; Emmely M. Wagener; Ziqin Tang; Senna Visser; Jolanda Kooiman; Jessica Buijs-Gladdines; Maria Rodionova; Esther A. Zaal; Jeroen W. A. Jansen; Jeroen F. van Velzen; Jarno Drost; Laurens T. van der Meer; Celia R. Berkers; Frank N. van Leeuwen
A non-canonical lymphoblast in refractory childhood T-cell leukaemia

难治性儿童T细胞白血病中的非典型淋巴母细胞

Nature Communications
IF15.7
2025-11-120
OAAI
Bram S. J. Lim; Holly J. Whitfield; Mi K. Trinh; Gianna Bloye; Rebecca Thomas; Nathaniel D. Anderson; Anna Wenger; Angus Hodder; Taryn D. Treger; Henry Lee-Six; Tim H. H. Coorens; Conor Parks; Toochi Ogbonnah; Petri Pölönen; Charles G. Mullighan; David T. Teachey; Jason Xu; Kai Tan; Melanie Hagleitner; Lennart Kester; Frank N. van Leeuwen; Gordon Beattie; Marc R. Mansour; Owen Williams; Jack Bartram; Stuart Adams; Laura Jardine; Sam Behjati; David O’Connor
S-adenosylmethionine addiction confers sensitivity to methionine restriction in KMT2A-rearranged acute lymphoblastic leukemia
HAEMATOLOGICA
IF7.9
2025-11-011
OAAI
Tee, Trisha; Ruiter, Titine J. J.; Wu, Shuiyan; Zhang, Weiya; Schenau, Dorette van Ingen; Rodionova, Maria; Wajon, Danique; Vervoort, Britt M. T.; Grunewald, Kari J. T.; Bosma, Marjolein; Hagelaar, Rico; Baker-Hernandez, John; Dahaoui, Ahmed; Schneider, Pauline; Verhoeven-Duif, Nanda M.; van der Meer, Laurens T.; van Leeuwen, Frank N.
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia

复发和难治性儿童T细胞急性淋巴细胞白血病的生物学基础、治疗挑战及新兴概念

Leukemia
IF13.4
2025-08-140
PRE
Patrícia Amaral; Rhona Christie; Daisy O. F. Gresham; Emma J. M. Lucas; Luyao Kevin Xu; Lena Behrmann; Jonathan Bond; Sofie Degerman; Frederik W. van Delft; Steven Goossens; Melanie Hagleitner; Chris Halsey; Nicholas Jones; Tim Lammens; Frank N. van Leeuwen; Marc R. Mansour; Panagiotis Ntziachristos; David O’Connor; João T. Barata
A Non-Canonical Lymphoblast in Refractory Childhood T-Cell Acute Lymphoblastic Leukemia

难治性儿童T细胞急性淋巴细胞白血病中的非经典淋巴细胞 blasts

BLOOD
IF23.1
2024-11-050
PRE
Lim, Bram S. J.; Whitfield, Holly J.; Trinh, Mi K.; Bloye, Gianna; Thomas, Rebecca; Anderson, Nathaniel D.; Wenger, Anna; Hodder, Angus; Treger, Taryn D.; Lee-Six, Henry; Coorens, Tim H. H.; Parks, Conor; Ogbonnah, Toochi; Polonen, Petri; Mullighan, Charles G.; Teachey, David T.; Hagleitner, Melanie M.; Kester, Lennart A.; van Leeuwen, Frank N.; Beattie, Gordon; Mansour, Marc R.; Williams, Owen; Bartram, Jack; Adams, Stuart; Jardine, Laura; Behjati, Sam; O'Connor, David
Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade

组合TYK2，mTOR和CDK4/6激酶阻断可有效靶向致癌TYK2 P760L激酶

HAEMATOLOGICA
IF7.9
2022-01-132
OAAI
Woess, Katharina; Macho-Maschler, Sabine; Schenau, Dorette S. van Ingen; Butler, Miriam; Lassnig, Caroline; Valcanover, Daniel; Poelzl, Andrea; Meissl, Katrin; Maurer, Barbara; Brandstoetter, Tania; Vogl, Claus; Koren, Anna; Kubicek, Stefan; Orlova, Anna; Moriggl, Richard; Strobl, Birgit; Sexl, Veronika; van Leeuwen, Frank N.; Kuiper, Roland P.; Muelle, Mathias

研究方向

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R
Roland P. Kuiper
H 指数:53论文数:241被引数:1.0万
P
Peter M. Hoogerbrugge
H 指数:53论文数:267被引数:9,820
B
Blanca Scheijen
H 指数:29论文数:84被引数:4,372
L
Laurens T. van der Meer
H 指数:13论文数:51被引数:1,737
C
Carl G. Figdor
H 指数:124论文数:878被引数:5.7万
E
Esmé Waanders
H 指数:31论文数:136被引数:3,697
E
Edwin Sonneveld
H 指数:45论文数:163被引数:7,492
A
Ad Geurts van Kessel
H 指数:74论文数:425被引数:2.2万
R
Rob Pieters
H 指数:104论文数:911被引数:3.9万
H 指数:0论文数:27被引数:471