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Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome 药理学方法增加循环酮体未能缓解Tafazzin基因敲低小鼠模型中巴特综合征所存在的肥厚型心肌病 Shafaati, Tanin; Greenwell, Amanda A.; Saed, Christina T.; Tabatabaei Dakhili, Seyed Amirhossein; Chan, Jordan S. F.; Dong, Linyue; Stenlund, Magnus J.; Ferrari, Sally R.; Han, Ruth; Kruger, Jennifer; Eaton, Farah; Gopal, Keshav; Davidge, Sandra T.; Oudit, Gavin Y.; Ussher, John R. 分享 收藏
Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy 二甲双胍减轻实验性糖尿病心肌病小鼠的舒张功能障碍 Chan, Jordan S. F.; Dakhili, Seyed Amirhossein Tabatabaei; Wu, Nadeen R.; Stenlund, Magnus J.; King, Alexa N.; Dong, Linyue; Mangra-Bala, Indiresh A.; Shafaati, Tanin; Ferrari, Sally R.; Greenwell, Amanda A.; Yang, Kunyan; Saed, Christina T.; Eaton, Farah; Gopal, Keshav; Steinberg, Gregory R.; Dyck, Jason R. B.; Ussher, John R. 分享 收藏
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Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity 开发一种选择性作用于外周组织的琥珀酰辅酶A:3-酮酸辅酶A转移酶抑制剂，以改善肥胖患者的血糖水平 Dakhili, Seyed Amirhossein Tabatabaei; Yang, Kunyan; Al Nebaihi, Hamdah; Greenwell, Amanda A.; Wuest, Melinda; Woodfield, Jenilee; Abou Farraj, Rabih; Saed, Christina T.; Chan, Jordan S. F.; Bhat, Rakesh K.; Mangra-Bala, Indiresh A.; Shafaati, Tanin; Gopal, Keshav; Eaton, Farah; Ferrari, Sally R.; Wagg, Cory S.; Capozzi, Megan E.; Campbell, Jonathan E.; Overduin, Michael; Velazquez-Martinez, Carlos A.; Glover, J. N. Mark; Wuest, Frank; Brocks, Dion R. 分享 收藏
Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy Chan, Jordan S. F.; Dakhili, Seyed Amirhossein Tabatabaei; Lorenzana-Carrillo, Maria Areli; Gopal, Keshav; Pulente, Serena M.; Greenwell, Amanda A.; Yang, Kunyan; Saed, Christina T.; Stenlund, Magnus J.; Ferrari, Sally R.; Mangra-Bala, Indiresh A.; Shafaati, Tanin; Bhat, Rakesh K.; Eaton, Farah; Overduin, Michael; Jorgensen, Sebastian Beck; Steinberg, Gregory R.; Mulvihill, Erin E.; Sutendra, Gopinath; Ussher, John R. 分享 收藏
Liraglutide alleviates experimental diabetic cardiomyopathy in a PDH-dependent manner Chan, Jordan S. F.; Greenwell, Amanda A.; Saed, Christina T.; Stenlund, Magnus J.; Mangra-Bala, Indiresh A.; Dakhili, Seyed Amirhossein Tabatabaei; Yang, Kunyan; Ferrari, Sally R.; Eaton, Farah; Gopal, Keshav; Ussher, John R. 分享 收藏
Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy Greenwell, Amanda A.; Tabatabaei Dakhili, Seyed Amirhossein; Wagg, Cory S.; Saed, Christina T.; Chan, Jordan S. F.; Yang, Kunyan; Mangra-Bala, Indiresh A.; Stenlund, Magnus J.; Eaton, Farah; Gopal, Keshav; Dyck, Jason R. B.; Lopaschuk, Gary D.; Ussher, John R. 分享 收藏
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis Gopal, Keshav; Abdualkader, Abdualrahman Mohammed; Li, Xiaobei; Greenwell, Amanda A.; Karwi, Qutuba G.; Altamimi, Tariq R.; Saed, Christina; Uddin, Golam M.; Darwesh, Ahmed M.; Jamieson, K. Lockhart; Kim, Ryekjang; Eaton, Farah; Seubert, John M.; Lopaschuk, Gary D.; Ussher, John R.; Batran, Rami Al 分享 收藏
Ketone ester administration improves glycemia in obese mice Dakhili, Seyed Amirhossein Tabatabaei; Yang, Kunyan; Locatelli, Cassandra A. A.; Saed, Christina T.; Greenwell, Amanda A.; Chan, Jordan S. F.; Chahade, Jadin J.; Scharff, Jared; Al-Imarah, Shahad; Eaton, Farah; Crawford, Peter A.; Gopal, Keshav; Mulvihill, Erin E.; Ussher, John R. 分享 收藏
Elucidating the sex differences in a translational mouse model of diabetic cardiomyopathy Gopal, Keshav; Saed, Christina; Chan, Jordan; Dimaano, Toni; Benyaminov, Faina; Greenwell, Amanda; Dakhili, Seyed Amirhossein Tabatabaei; Eaton, Farah; Al Batran, Rami; Ussher, John 分享 收藏
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure Lorenzana-Carrillo, Maria Areli; Gopal, Keshav; Byrne, Nikole J.; Tejay, Saymon; Saleme, Bruno; Das, Subhash K.; Zhang, Yongneng; Haromy, Alois; Eaton, Farah; Pla, Michelle Mendiola; Bowles, Dawn E.; Dyck, Jason R. B.; Ussher, John R.; Michelakis, Evangelos D.; Sutendra, Gopinath 分享 收藏
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase Dakhili, Seyed Amirhossein Tabatabaei; Greenwell, Amanda A.; Yang, Kunyan; Abou Farraj, Rabih; Saed, Christina T.; Gopal, Keshav; Chan, Jordan S. F.; Chahade, Jadin J.; Eaton, Farah; Lee, Crystal; Velazquez-Martinez, Carlos A.; Crawford, Peter A.; Glover, J. N. Mark; Al Batran, Rami; Ussher, John R. 分享 收藏
Pulmonary and Neurologic Effects of Mesenchymal Stromal Cell Extracellular Vesicles in a Multifactorial Lung Injury Model 在多因素肺损伤模型中，间充质基质细胞外囊泡的肺和神经作用 Lithopoulos, Marissa A.; Strueby, Lannae; O'Reilly, Megan; Zhong, Shumei; Mobius, Marius A.; Eaton, Farah; Fung, Moses; Hurskainen, Maria; Cyr-Depauw, Chanele; Suen, Colin; Xu, Liqun; Collins, Jennifer J. P.; Vadivel, Arul; Stewart, Duncan J.; Burger, Dylan; Thebaud, Bernard 分享 收藏
FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity Gopal, Keshav; Al Batran, Rami; Altamimi, Tariq R.; Greenwell, Amanda A.; Saed, Christina T.; Dakhili, Seyed Amirhossein Tabatabaei; Dimaano, M. Toni E.; Zhang, Yongneng; Eaton, Farah; Sutendra, Gopinath; Ussher, John R. 分享 收藏
Neural crest-specific loss of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction and disordered breathing, modeling obstructive sleep apnea 神经嵴特异性Bmp7缺失导致面中部发育不全，鼻气道阻塞和呼吸障碍，模拟阻塞性睡眠呼吸暂停 Baddam, Pranidhi; Biancardi, Vivian; Roth, Daniela M.; Eaton, Farah; Thereza-Bussolaro, Claudine; Mandal, Rupasri; Wishart, David S.; Barr, Amy; MacLean, Joanna; Flores-Mir, Carlos; Pagliardini, Silvia; Graf, Daniel 分享 收藏
The GLP-1 Receptor Agonist Liraglutide Increases Myocardial Glucose Oxidation Rates via Indirect Mechanisms and Mitigates Experimental Diabetic Cardiomyopathy GLP-1受体激动剂利拉鲁肽通过间接机制增加心肌葡萄糖氧化率并减轻实验性糖尿病心肌病 Almutairi, Malak; Gopal, Keshav; Greenwell, Amanda A.; Young, Adrian; Gill, Robert; Aburasayn, Hanin; Al Batran, Rami; Chahade, Jadin J.; Gandhi, Manoj; Eaton, Farah; Mailloux, Ryan J.; Ussher, John R. 分享 收藏
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Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation Al Batran, Rami; Gopal, Keshav; Capozzi, Megan E.; Chahade, Jadin J.; Saleme, Bruno; Tabatabaei-Dakhili, S. Amirhossein; Greenwell, Amanda A.; Niu, Jingjing; Almutairi, Malak; Byrne, Nikole J.; Masson, Grant; Kim, Ryekjang; Eaton, Farah; Mulvihill, Erin E.; Garneau, Lea; Masters, Andrea R.; Desta, Zeruesenay; Velazquez-Martinez, Carlos A.; Aguer, Celine; Crawford, Peter A.; Sutendra, Gopinath; Campbell, Jonathan E.; Dyck, Jason R. B.; Ussher, John R. 分享 收藏
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