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I

Irwin Chaiken

drexel university

48H指数
282论文数
9.3K被引数
收录论文 62
发表时间
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Inflammation and RONS Dysregulation by Redox Enzymes as Mechanistic Links in HIV-1–Cancer Comorbidity氧化还原酶介导的炎症和活性氧氮物种失调作为HIV-1–癌症共病机制性联系
errPathogens
IF3.3
err2026-04-14
err0
errOAAI
errCharles Gotuaco Ang; Shreya Eyunni; Irwin M. Chaiken
err分享
err收藏
Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection
errJOURNAL OF VIROLOGY
IF3.8
err2025-02-06
err0
errOAAI
errAng, Charles G.; Hyatt, Nadia L.; Le Minh, Giang; Gupta, Monisha; Kadam, Manali; Hogg, Philip J.; Smith III, Amos B.; Chaiken, Irwin M.
err分享
err收藏
Monovalent Lectin Microvirin Utilizes Hydropathic Recognition of HIV-1 Env for Inhibition of Virus Cell Infection
errVIRUSES-BASEL
IF3.5
err2025-01-09
err0
errOAAI
errParajuli, Bibek; Acharya, Kriti; Bach, Harry Charles; Zhang, Shiyu; Abrams, Cameron F.; Chaiken, Irwin
err分享
err收藏
Injectable Granular Hydrogels Enable Avidity-Controlled Biotherapeutic Delivery
errACS BIOMATERIALS SCIENCE & ENGINEERING
IF5.5
err2024-02-15
err4
errOAAI
errD'Elia, Arielle M.; Jones, Olivia L.; Canziani, Gabriela; Sarkar, Biplab; Chaiken, Irwin; Rodell, Christopher B.
err分享
err收藏
Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-03-14
err4
errOAAI
errGary, Ebony N.; Tursi, Nicholas J.; Warner, Bryce M.; Cuismano, Gina; Connors, Jennifer; Parzych, Elizabeth M.; Griffin, Bryan D.; Bell, Matthew R.; Ali, Ali R.; Frase, Drew; Hojecki, Casey E.; Canziani, Gabriela A.; Chaiken, Irwin; Kannan, Toshitha; Moffat, Estella; Embury-Hyatt, Carissa; Wooton, Sarah K.; Kossenkov, Andrew; Patel, Ami; Kobasa, Darwyn; Kutzler, Michele A.; Haddad, Elias K.; Weiner, David B.
err分享
err收藏
Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1
errJOURNAL OF IMMUNOLOGY
IF3.4
err2022-07-01
err3
errOAAI
errCusimano, Gina M.; Gary, Ebony N.; Bell, Matthew R.; Warner, Bryce M.; Connors, Jennifer; Tursi, Nicholas J.; Ali, Ali R.; Zhang, Shiyu; Canziani, Gabriela; Taramangalam, Bhavani; Gordon, Emma A.; Chaiken, Irwin M.; Wootton, Sarah K.; Smith, Trevor; Ramos, Stephanie; Kobasa, Darwyn; Weiner, David B.; Kutzler, Michele A.; Haddad, Elias K.
err分享
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Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry
errMICROORGANISMS
IF4.2
err2021-06-12
err4
errOAAI
errAng, Charles Gotuaco; Carter, Erik; Haftl, Ann; Zhang, Shiyu; Rashad, Adel A.; Kutzler, Michele; Abrams, Cameron F.; Chaiken, Irwin M.
err分享
err收藏
The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 PandemicS2的案例: SARS-CoV-2刺突蛋白S2亚基作为免疫原在对抗新型冠状病毒肺炎大流行中的潜在益处
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2021-03-09
err97
errOAAI
errShah, Priyanka; Canziani, Gabriela A.; Carter, Erik P.; Chaiken, Irwin
err分享
err收藏
HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates (vol 16, pg 193, 2021)
errACS CHEMICAL BIOLOGY
IF3.8
err2021-02-04
err0
errOAAI
errGaffney, Althea; Nangarlia, Aakansha; Ang, Charles G.; Gossert, Steven; Ahmed, Adel Ahmed Rashad; Hossain, Md Alamgir; Abrams, Cameron F.; Smith, Amos B.; Chaiken, Irwin
err分享
err收藏
HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates
errACS CHEMICAL BIOLOGY
IF3.8
err2021-01-07
err10
errOAAI
errGaffney, Althea; Nangarlia, Aakansha; Ang, Charles G.; Gossert, Steven; Ahmed, Adel Ahmed Rashad; Hossain, Md Alamgir; Abrams, Cameron F.; Smith, Amos B., III; Chaiken, Irwin
err分享
err收藏
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding SiteHIV-1 Env gp120内部结构域形成Phe43腔和CD4结合位点
errMBIO
IF4.7
err2020-06-30
err38
errOAAI
errPrevost, Jeremie; Tolbert, William D.; Medjahed, Halima; Sherburn, Rebekah T.; Madani, Navid; Zoubchenok, Daria; Gendron-Lepage, Gabrielle; Gaffney, Althea E.; Grenier, Melissa C.; Kirk, Sharon; Vergara, Natasha; Han, Changze; Mann, Brendan T.; Chenine, Agnes L.; Ahmed, Adel; Chaiken, Irwin; Kirchhoff, Frank; Hahn, Beatrice H.; Haim, Hillel; Abrams, Cameron F.; Smith, Amos B., III; Sodroski, Joseph; Pazgier, Marzena; Finzi, Andres
err分享
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Mechanical characterization of HIV-1 with a solid-state nanopore sensor使用固态纳米孔传感器对HIV-1进行机械表征
errELECTROPHORESIS
IF2.5
err2018-09-07
err42
errOAAI
errDarvish, Armin; Lee, Jung Soo; Peng, Bin; Saharia, Jugal; Sundaram, Ramalingam Venkat Kalyana; Goyal, Gaurav; Bandara, Nuwan; Ahn, Chi Won; Kim, Jungsuk; Dutta, Prashanta; Chaiken, Irwin; Kim, Min Jun
err分享
err收藏
Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2018-05-16
err12
errOAAI
errRashad, Adel A.; Song, Li-Rui; Holmes, Andrew P.; Acharya, Kriti; Zhang, Shiyu; Wang, Zhi-Long; Gary, Ebony; Xie, Xin; Pirrone, Vanessa; Kutzler, Michele A.; Long, Ya-Qiu; Chaiken, Irwin
err分享
err收藏
Roles of conserved tryptophans in trimerization of HIV-1 membrane-proximal external regions: Implications for virucidal design via alchemical free-energy molecular simulations保守色氨酸在HIV-1膜近端外部区域三聚化中的作用: 通过炼化自由能分子模拟对杀病毒设计的影响
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2018-04-19
err6
errOAAI
errGossert, Steven T.; Parajuli, Bibek; Chaiken, Irwin; Abrams, Cameron F.
err分享
err收藏
Restricted HIV-1 Env glycan engagement by lectin-reengineered DAVEI protein chimera is sufficient for lytic inactivation of the virus
errBIOCHEMICAL JOURNAL
IF4.3
err2018-03-09
err23
errOAAI
errParajuli, Bibek; Acharya, Kriti; Bach, Harry C.; Parajuli, Bijay; Zhang, Shiyu; Smith, Amos B., III; Abrams, Cameron F.; Chaiken, Irwin
err分享
err收藏
Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2017-03-11
err7
errOAAI
errAcharya, Kriti; Rashad, Adel A.; Moraca, Francesca; Klasse, Per Johan; Moore, John P.; Abrams, Cameron; Chaiken, Irwin
err分享
err收藏
Computational Evaluation of HIV-1 gp120 Conformations of Soluble Trimeric gp140 Structures as Targets for de Novo Docking of First- and Second-Generation Small-Molecule CD4 Mimics
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2016-09-26
err8
errOAAI
errMoraca, Francesca; Acharya, Kriti; Melillo, Bruno; Smith, Amos B., III; Chaiken, Irwin; Abrams, Cameron F.
err分享
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Peptide triazole inactivators of HIV-1: how do they work and what is their potential?
errFUTURE MEDICINAL CHEMISTRY
IF3.4
err2015-11-24
err11
errOAAI
errChaiken, Irwin; Rashad, Adel A.
err分享
err收藏
Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols
errACS CHEMICAL BIOLOGY
IF3.8
err2015-10-22
err17
errOAAI
errBailey, Lauren D.; Sundaram, Ramalingam Venkat Kalyana; Li, Huiyuan; Duffy, Caitlin; Aneja, Rachna; Bastian, Arangassery Rosemary; Holmes, Andrew P.; Kamanna, Kantharaju; Rashad, Adel A.; Chaiken, Irwin
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err收藏
Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2015-09-11
err35
errOAAI
errRashad, Adel A.; Sundaram, Ramalingam Venkat Kalyana; Aneja, Rachna; Duffy, Caitlin; Chaiken, Irwin
err分享
err收藏

研究方向

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合作学者
合作期刊
B
Beatrice H. Hahn
H 指数: 140 · 论文数: 661
J
Joseph Sodroski
H 指数: 134 · 论文数: 544
J
John P. Moore
H 指数: 132 · 论文数: 572
P
Peter D. Kwong
H 指数: 122 · 论文数: 734
R
Robert W. Doms
H 指数: 111 · 论文数: 410
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