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Evaluation of PXL065-deuterium-stabilized (R)-pioglitazone in patients with NASH: A phase II randomized placebo- controlled trial (DESTINY-1) Harrison, Stephen A.; Thang, Carole; Bolze, Sebastien; Dewitt, Sheila; Hallakou-Bozec, Sophie; Dubourg, Julie; Bedossa, Pierre; Cusi, Kenneth; Ratziu, Vlad; Grouin, Jean-Marie; Moller, David E.; Fouqueray, Pascale 分享 收藏
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Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy 直接AMP激酶激活剂PXL770在X连锁肾上腺脑白质营养不良的体外和体内模型中的有益作用 Monternier, Pierre-Axel; Parasar, Parveen; Theurey, Pierre; Dagorn, Pascale Gluais; Kaur, Navtej; Nagaraja, Tavarekere N.; Fouqueray, Pascale; Bolze, Sebastien; Moller, David E.; Singh, Jaspreet; Hallakou-Bozec, Sophie 分享 收藏
Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study 胰岛素抵抗和非酒精性脂肪肝患者直接激活AMP激酶的药效学效应: 1b期研究 Fouqueray, Pascale; Bolze, Sebastien; Dubourg, Julie; Hallakou-Bozec, Sophie; Theurey, Pierre; Grouin, Jean-Marie; Chevalier, Clemence; Gluais-Dagorn, Pascale; Moller, David E.; Cusi, Kenneth 分享 收藏
Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo- controlled, phase 2a study 直接AMP激酶激活剂PXL770治疗非酒精性脂肪性肝病 (stamp-nafld) 的疗效和安全性: 一项随机、双盲、安慰剂对照、2a期研究 Cusi, Kenneth; Alkhouri, Naim; Harrison, Stephen A.; Fouqueray, Pascale; Moller, David E.; Hallakou-Bozec, Sophie; Bolze, Sebastien; Grouin, Jean-Marie; Megnien, Sophie Jeannin; Dubourg, Julie; Ratziu, Vlad 分享 收藏
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Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis 直接AMPK激活通过代谢作用和对炎症和纤维发生的直接作用来纠正啮齿动物的NASH Gluais-Dagorn, Pascale; Foretz, Marc; Steinberg, Gregory R.; Batchuluun, Battsetseg; Zawistowska-Deniziak, Anna; Lambooij, Joost M.; Guigas, Bruno; Carling, David; Monternier, Pierre-Axel; Moller, David E.; Bolze, Sebastien; Hallakou-Bozec, Sophie 分享 收藏
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Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies (vol 39, pg 1241, 2016) Kazda, Christof M.; Ding, Ying; Kelly, Ronan P.; Garhyan, Parag; Shi, Chunxue; Lim, Chay Ngee; Fu, Haoda; Watson, David E.; Lewin, Andrew J.; Landschulz, William H.; Deeg, Mark A.; Moller, David E.; Hardy, Thomas A. 分享 收藏
Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12-and 24-Week Phase 2 Studies. Diabetes Care 2016;39:1241-1249 Kazda, Christof M.; Ding, Ying; Kelly, Ronan P.; Garhyan, Parag; Shi, Chunxue; Lim, Chay Ngee; Fu, Haoda; Watson, David E.; Lewin, Andrew J.; Landschulz, William H.; Deeg, Mark A.; Moller, David E.; Hardy, Thomas A. 分享 收藏
Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12-and 24-Week Phase 2 Studies Kazda, Christof M.; Ding, Ying; Kelly, Ronan P.; Garhyan, Parag; Shi, Chunxue; Lim, Chay Ngee; Fu, Haoda; Watson, David E.; Lewin, Andrew J.; Landschulz, William H.; Deeg, Mark A.; Moller, David E.; Hardy, Thomas A. 分享 收藏
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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisonne Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume (vol 52, pg 3846, 2009) Acton, John J.; Akiyama, Taro E.; Chang, Ching H.; Colwell, Lawrence; Debenham, Sheryl; Doebber, Thomas; Einstein, Monica; Liu, Kun; McCann, Margaret E.; Moller, David E.; Muise, Eric S.; Tan, Yejun; Thompson, John R.; Wong, Kenny K.; Wu, Margaret; Xu, Libo; Meinke, Peter T.; Berger, Joel P.; Wood, Harold B. 分享 收藏
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The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes Gaich, Gregory; Chien, Jenny Y.; Fu, Haoda; Glass, Leonard C.; Deeg, Mark A.; Holland, William L.; Kharitonenkov, Alexei; Bumol, Thomas; Schilske, Holger K.; Moller, David E. 分享 收藏
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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume Acton, John J., III; Akiyama, Taro E.; Chang, Ching H.; Colwell, Lawrence; Debenham, Sheryl; Doebber, Thomas; Einstein, Monica; Liu, Kun; McCann, Margaret E.; Moller, David E.; Muise, Eric S.; Tan, Yugen; Thompson, John R.; Wong, Kenny K.; Wu, Margaret; Xu, Libo; Meinke, Peter T.; Berger, Joel P.; Wood, Harold B. 分享 收藏
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