George G. Holz - Publications, H-index & Citations

George G. Holz

University of Pennsylvania

59H指数

218论文数

1.2W被引数

收录论文 57

发表时间

A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity 一种黑色素皮质素4受体和胰高血糖素样肽1受体的多重激动剂，用于治疗糖尿病和肥胖症

Metabolism

IF3.7

2025-10-13

OAAI

Emily F. Ashlaw; Clinton T. Elfers; Kylie S. Chichura; Isabella Chavez Miranda; Aelish McGivney; Oleg G. Chepurny; George G. Holz; Ginger Mullins; Laura J. den Hartigh; Yongjun Liu; Christian L. Roth; Robert P. Doyle

Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells

MOLECULES

IF4.6

2024-08-30

OAAI

Markatos, Christos; Biniari, Georgia; Chepurny, Oleg G.; Karageorgos, Vlasios; Tsakalakis, Nikos; Komontachakis, Georgios; Vlata, Zacharenia; Venihaki, Maria; Holz, George G.; Tselios, Theodore; Liapakis, George

Reductions of food intake and body weight in diet-induced obese rats following chronic treatment with a monomeric peptide multiagonist

CLINICAL NUTRITION

IF7.4

2024-07-01

PREAI

Elfers, Clinton T.; Chichura, Kylie S.; Ashlaw, Emily F.; Chepurny, Oleg G.; Holz, George G.; Doyle, Robert P.; Roth, Christian L.

Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

CELL METABOLISM

IF30.9

2023-07-01

OAAI

Basile, Giorgio; Vetere, Amedeo; Hu, Jiang; Ijaduola, Oluwaseun; Zhang, Yi; Liu, Ka-Cheuk; Eltony, Amira M.; De Jesus, Dario F.; Fukuda, Kazuki; Doherty, Grace; Leech, Colin A.; Chepurny, Oleg G.; Holz, George G.; Yun, Seok-Hyun; Andersson, Olov; Choudhary, Amit; Wagner, Bridget K.; Kulkarni, Rohit N.

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

SCIENTIFIC REPORTS

IF3.9

2023-06-12

OAAI

Chichura, Kylie S.; Elfers, Clinton T.; Salameh, Therese S.; Kamat, Varun; Chepurny, Oleg G.; McGivney, Aelish; Milliken, Brandon T.; Holz, George G.; Applebey, Sarah V.; Hayes, Matthew R.; Sweet, Ian R.; Roth, Christian L.; Doyle, Robert P.

GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice

SCIENTIFIC REPORTS

IF3.9

2022-12-26

OAAI

Meng, Qinghe; Tian, Xinghan; Li, Junwei; Pruekprasert, Napat; Dhawan, Ravi; Holz, George G.; Cooney, Robert N.

The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice

DIABETES OBESITY & METABOLISM

IF5.7

2022-04-07

OAAI

Meng, Qinghe; Chepurny, Oleg G.; Leech, Colin A.; Pruekprasert, Napat; Molnar, Megan E.; Collier, James Jason; Cooney, Robert N.; Holz, George G.

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study

PHARMACEUTICS

IF5.5

2022-03-18

OAAI

Nock, Berthold A.; Kanellopoulos, Panagiotis; Chepurny, Oleg G.; Rouchota, Maritina; Loudos, George; Holz, George G.; Krenning, Eric P.; Maina, Theodosia

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-02-01

OAAI

Cabrera, Over; Ficorilli, James; Shaw, Janice; Echeverri, Felipe; Schwede, Frank; Chepurny, Oleg G.; Leech, Colin A.; Holz, George G.

Cyclic AMP-dependent Activation of ERK Via GLP-1 Receptor Signaling Requires the Neuroendocrine Cell-Selective Guanine Nucleotide Exchanger NCS-RapGEF2

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Xu, Wenqin; Dahlke, Sam; Emery, Andrew; Chepurny, Oleg; Holz, George; Eiden, Lee

Cyclic AMP-dependent activation of ERK via GLP-1 receptor signalling requires the neuroendocrine cell-specific guanine nucleotide exchanger NCS-RapGEF2

JOURNAL OF NEUROENDOCRINOLOGY

IF4.1

2021-05-06

OAAI

Xu, Wenqin; Dahlke, Sam P.; Emery, Andrew C.; Sung, Michelle; Chepurny, Oleg G.; Holz, George G.; Eiden, Lee E.

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-03-06

OAAI

Tinsley, Ian C.; Borner, Tito; Swanson, MacKenzie L.; Chepurny, Oleg G.; Doebley, Sarah A.; Kamat, Varun; Sweet, Ian R.; Holz, George G.; Hayes, Matthew R.; De Jonghe, Bart C.; Doyle, Robert P.

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-01-15

OAAI

Milliken, Brandon T.; Elfers, Clinton; Chepurny, Oleg G.; Chichura, Kylie S.; Sweet, Ian R.; Borner, Tito; Hayes, Matthew R.; De Jonghe, Bart C.; Holz, George G.; Roth, Christian L.; Doyle, Robert P.

Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor

AMINO ACIDS

IF2.4

2020-09-29

OAAI

Liapakis, George; Karageorgos, Vlasios; Andreadelis, Ioannis; Holz, George G.; Dermitzaki, Eirini; Kordopati, Golfo G.; Stylos, Evgenios K.; Spyridaki, Katerina; Poulaki, Smaragda; Ntountaniotis, Dimitris; Sakellaris, Stelios; Vanioti, Marianna; Kostagianni, Androniki; Marousis, Konstantinos D.; Leonis, Georgios; Kokotos, George; Venihaki, Maria; Spyroulias, Georgios A.; Tselios, Theodoros; Margioris, Andrew; Tzakos, Andreas G.; Mavromoustakos, Thomas

Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

IF8

2020-08-26

OAAI

Xie, Han; Yepuri, Natesh; Meng, Qinghe; Dhawan, Ravi; Leech, Colin A.; Chepurny, Oleg G.; Holz, George G.; Cooney, Robert N.

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

CELL REPORTS

IF6.9

2020-06-01

OAAI

Borner, Tito; Workinger, Jayme L.; Tinsley, Ian C.; Fortin, Samantha M.; Stein, Lauren M.; Chepurny, Oleg G.; Holz, George G.; Wierzba, Aleksandra J.; Gryko, Dorota; Nexo, Ebba; Shaulson, Evan D.; Bamezai, Ankur; Rodriguez Da Silva, Valentina A.; De Jonghe, Bart C.; Hayes, Matthew R.; Doyle, Robert P.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP (vol 294, pg 3514, 2019)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-05-01

OAAI

Chepurny, Oleg G.; Matsuokas, Minos-Timotheos; Liapakis, George; Leech, Colin A.; Milliken, Brandon T.; Doyle, Robert P.; Holz, George G.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-03-01

OAAI

Chepurny, Oleg G.; Matsoukas, Minos-Timotheos; Liapakis, George; Leech, Colin A.; Milliken, Brandon T.; Doyle, Robert P.; Holz, George G.