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Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2 深度突变学习在针对SARS-CoV-2 Omicron变异体进化耐药性的治疗性抗体筛选中的应用 Frei, Lester; Gao, Beichen; Han, Jiami; Taft, Joseph M.; Irvine, Edward B.; Weber, Cedric R.; Kumar, Rachita K.; Eisinger, Benedikt N.; Ignatov, Andrey; Yang, Zhouya 分享 收藏
The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations Csepregi, Lucia; Hoehn, Kenneth; Neumeier, Daniel; Taft, Joseph M.; Friedensohn, Simon; Weber, Cedric R.; Kummer, Arkadij; Sesterhenn, Fabian; Correia, Bruno E.; Reddy, Sai T. 分享 收藏
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies 工程改造的同种异体T细胞解耦T细胞受体和CD3信号增强双特异性抗体的抗肿瘤活性 Kapetanovic, Edo; Weber, Cedric R.; Bruand, Marine; Poschl, Daniel; Kucharczyk, Jakub; Hirth, Elisabeth; Dietsche, Claudius; Khan, Riyaz; Wagner, Bastian; Belli, Olivier; Vazquez-Lombardi, Rodrigo; Castellanos- Rueda, Rocio; Di Roberto, Raphael B.; Kalinka, Kevin; Raess, Luca; Ly, Kevin; Rai, Shivam; Dittrich, Petra S.; Platt, Randall J.; Oricchio, Elisa; Reddy, Sai T. 分享 收藏
High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity Vazquez-Lombardi, Rodrigo; Jung, Johanna S.; Schlatter, Fabrice S.; Mei, Anna; Mantuano, Natalia Rodrigues; Bieberich, Florian; Hong, Kai-Lin; Kucharczyk, Jakub; Kapetanovic, Edo; Aznauryan, Erik; Weber, Cedric R.; Zippelius, Alfred; Laubli, Heinz; Reddy, Sai T. 分享 收藏
Reference-based comparison of adaptive immune receptor repertoires Weber, Cedric R.; Rubio, Teresa; Wang, Longlong; Zhang, Wei; Robert, Philippe A.; Akbar, Rahmad; Snapkov, Igor; Wu, Jinghua; Kuijjer, Marieke L.; Tarazona, Sonia; Conesa, Ana; Sandve, Geir K.; Liu, Xiao; Reddy, Sai T.; Greiff, Victor 分享 收藏
In silico proof of principle of machine learning-based antibody design at unconstrained scale Akbar, Rahmad; Robert, Philippe A.; Weber, Cedric R.; Widrich, Michael; Frank, Robert; Pavlovic, Milena; Scheffer, Lonneke; Chernigovskaya, Maria; Snapkov, Igor; Slabodkin, Andrei; Mehta, Brij Bhushan; Miho, Enkelejda; Lund-Johansen, Fridtjof; Andersen, Jan Terje; Hochreiter, Sepp; Haff, Ingrid Hobaek; Klambauer, Guenter; Sandve, Geir Kjetil; Greiff, Victor 分享 收藏
SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display Ehling, Roy A.; Weber, Cedric R.; Mason, Derek M.; Friedensohn, Simon; Wagner, Bastian; Bieberich, Florian; Kapetanovic, Edo; Vazquez-Lombardi, Rodrigo; Di Roberto, Raphael B.; Hong, Kai-Lin; Wagner, Camille; Pataia, Michele; Overath, Max D.; Sheward, Daniel J.; Murrell, Ben; Yermanos, Alexander; Cuny, Andreas P.; Savic, Miodrag; Rudolf, Fabian; Reddy, Sai T. 分享 收藏
Individualized VDJ recombination predisposes the available Ig sequence space Slabodkin, Andrei; Chernigovskaya, Maria; Mikocziova, Ivana; Akbar, Rahmad; Scheffer, Lonneke; Pavlovic, Milena; Bashour, Habib; Snapkov, Igor; Mehta, Brij Bhushan; Weber, Cedric R.; Gutierrez-Marcos, Jose; Sollid, Ludvig M.; Haff, Ingrid Hobaek; Sandve, Geir Kjetil; Robert, Philippe A.; Greiff, Victor 分享 收藏
The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires Pavlovic, Milena; Scheffer, Lonneke; Motwani, Keshav; Kanduri, Chakravarthi; Kompova, Radmila; Vazov, Nikolay; Waagan, Knut; Bernal, Fabian L. M.; Costa, Alexandre Almeida; Corrie, Brian; Akbar, Rahmad; Al Hajj, Ghadi S.; Balaban, Gabriel; Brusko, Todd M.; Chernigovskaya, Maria; Christley, Scott; Cowell, Lindsay G.; Frank, Robert; Grytten, Ivar; Gundersen, Sveinung; Haff, Ingrid Hobaek; Hovig, Eivind; Hsieh, Ping-Han; Klambauer, Gunter; Kuijjer, Marieke L.; Lund-Andersen, Christin; Martini, Antonio; Minotto, Thomas; Pensar, Johan; Rand, Knut; Riccardi, Enrico; Robert, Philippe A.; Rocha, Artur; Slabodkin, Andrei; Snapkov, Igor; Sollid, Ludvig M.; Titov, Dmytro; Weber, Cedric R.; Widrich, Michael; Yaari, Gur; Greiff, Victor; Sandve, Geir Kjetil 分享 收藏
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning Mason, Derek M.; Friedensohn, Simon; Weber, Cedric R.; Jordi, Christian; Wagner, Bastian; Meng, Simon M.; Ehling, Roy A.; Bonati, Lucia; Dahinden, Jan; Gainza, Pablo; Correia, Bruno E.; Reddy, Sai T. 分享 收藏
Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes Yermanos, Alexander; Agrafiotis, Andreas; Kuhn, Raphael; Robbiani, Damiano; Yates, Josephine; Papadopoulou, Chrysa; Han, Jiami; Sandu, Ioana; Weber, Cedric; Bieberich, Florian; Vazquez-Lombardi, Rodrigo; Dounas, Andreas; Neumeier, Daniel; Oxenius, Annette; Reddy, Sai T. 分享 收藏
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding Akbar, Rahmad; Robert, Philippe A.; Pavlovic, Milena; Jeliazkov, Jeliazko R.; Snapkov, Igor; Slabodkin, Andrei; Weber, Cedric R.; Scheffer, Lonneke; Miho, Enkelejda; Haff, Ingrid Hobaek; Haug, Dag Trygve Tryslew; Lund-Johansen, Fridtjof; Safonova, Yana; Sandve, Geir K.; Greiff, Victor 分享 收藏
A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients Bieberich, Florian; Vazquez-Lombardi, Rodrigo; Yermanos, Alexander; Ehling, Roy A.; Mason, Derek M.; Wagner, Bastian; Kapetanovic, Edo; Di Roberto, Raphael Brisset; Weber, Cedric R.; Savic, Miodrag; Rudolf, Fabian; Reddy, Sai T. 分享 收藏
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Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development Greiff, Victor; Menzel, Ulrike; Miho, Enkelejda; Weber, Cedric; Riedel, Rene; Cook, Skylar; Valai, Atijeh; Lopes, Telma; Radbruch, Andreas; Winkler, Thomas H.; Reddy, Sai T. 分享 收藏
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