Ralph A. Nixon - Publications, H-index & Citations

Ralph A. Nixon

kline institute

116H指数

436论文数

6.3W被引数

收录论文 141

发表时间

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain 自噬-溶酶体通路在亨廷顿病脑中的病理生物学

Acta Neuropathologica Communications

IF5.7

2025-11-08

OAAI

Martin J. Berg; Veeranna; Corrinne M. Rosa; Asok Kumar; Panaiyur S. Mohan; Philip Stavrides; Sandipkumar Darji; Deanna M. Marchionini; Dun-Sheng Yang; Ralph A. Nixon

Profiling lamina specific pyramidal neurons using postmortem human formalin fixed paraffin embedded frontal cortex tissue in combination with digital spatial profiling 利用死后人类甲醛固定石蜡包埋额叶皮质组织，结合数字空间剖析技术，对特定层锥体神经元进行特征分析。

Journal of Neuroscience Methods

IF2.3

2025-06-03

OAAI

Aleksandra Stanisavljevic; Kyrillos W. Ibrahim; Philip H. Stavrides; Christopher Bare; Melissa J. Alldred; Adriana Heguy; Ralph A. Nixon; Stephen D. Ginsberg

Calpastatin, a calpain specific inhibitor, reduce seizures in a mouse model of temporal lobe epilepsy Calpastatin，一种calpain特异性抑制剂，可减轻颞叶癫痫小鼠模型的癫痫发作。

EPILEPSIA OPEN

IF2.9

2025-04-28

OAAI

Philip M. Lam; Mala V. Rao; Ralph A. Nixon; Marco I. González

Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation

HUMAN MOLECULAR GENETICS

IF3.2

2024-09-26

PREAI

Fuller, Peyton E.; Collis, Victoria L.; Sharma, Pallavi; Burkett, Angelina M.; Wang, Shaoteng; Brown, Kyle A.; Weir, Nick; Goulbourne, Chris N.; Nixon, Ralph A.; Longden, Thomas A.; Gould, Todd D.; Monteiro, Mervyn J.

Autophagy-lysosomal-associated neuronal death in neurodegenerative disease 神经退行性疾病中自噬-溶酶体相关神经元死亡

ACTA NEUROPATHOLOGICA

IF9.3

2024-09-11

PREAI

Nixon, Ralph A.

Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases

NATURE REVIEWS MOLECULAR CELL BIOLOGY

IF90.2

2024-08-06

PREAI

Nixon, Ralph A.; Rubinsztein, David C.

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come (vol 18, 74, 2023)

MOLECULAR NEURODEGENERATION

IF17.5

2023-11-09

OAAI

Alam, John J.; Nixon, Ralph A.

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come

MOLECULAR NEURODEGENERATION

IF17.5

2023-10-04

OAAI

Alam, John J.; Nixon, Ralph A.

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF

SCIENCE ADVANCES

IF12.5

2023-07-28

OAAI

Im, Eunju; Jiang, Ying; Stavrides, Philip H. H.; Darji, Sandipkumar; Erdjument-Bromage, Hediye; Neubert, Thomas A. A.; Choi, Jun Yong; Wegiel, Jerzy; Lee, Ju-Hyun; Nixon, Ralph A.

Posttranscriptional regulation of neurofilament proteins and tau in health and disease

BRAIN RESEARCH BULLETIN

IF3.7

2023-01-01

OAAI

Yuan, Aidong; Nixon, Ralph A.

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

NATURE COMMUNICATIONS

IF15.7

2022-09-21

OAAI

Jiang, Ying; Alam, John J.; Gomperts, Stephen N.; Maruff, Paul; Lemstra, Afina W.; Germann, Ursula A.; Stavrides, Philip H.; Darji, Sandipkumar; Malampati, Sandeep; Peddy, James; Bleiwas, Cynthia; Pawlik, Monika; Pensalfini, Anna; Yang, Dun-Sheng; Subbanna, Shivakumar; Basavarajappa, Balapal S.; Smiley, John F.; Gardner, Amanda; Blackburn, Kelly; Chu, Hui-May; Prins, Niels D.; Teunissen, Charlotte E.; Harrison, John E.; Scheltens, Philip; Nixon, Ralph A.

Autophagy is a novel pathway for neurofilament protein degradation in vivo

AUTOPHAGY

IF14.3

2022-09-21

OAAI

Rao, Mala, V; Darji, Sandipkumar; Stavrides, Philip H.; Goulbourne, Chris N.; Kumar, Asok; Yang, Dun-Sheng; Yoo, Lang; Peddy, James; Lee, Ju-Hyun; Yuan, Aidong; Nixon, Ralph A.

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

AUTOPHAGY

IF14.3

2022-08-23

OAAI

Lee, Ju-Hyun; Nixon, Ralph A.

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function

SCIENCE ADVANCES

IF12.5

2022-04-29

OAAI

Lie, Pearl P. Y.; Yoo, Lang; Goulbourne, Chris N.; Berg, Martin J.; Stavrides, Philip; Huo, Chunfeng; Lee, Ju-Hyun; Nixon, Ralph A.

A gene toolbox for monitoring autophagy transcription

CELL DEATH & DISEASE

IF9.6

2021-11-02

OAAI

Bordi, Matteo; De Cegli, Rossella; Testa, Beatrice; Nixon, Ralph A.; Ballabio, Andrea; Cecconi, Francesco

Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies

FRONTIERS IN NEUROSCIENCE

IF3.2

2021-09-27

168

OAAI

Yuan, Aidong; Nixon, Ralph A.

Disease-modifying pharmacological approaches to correcting basal forebrain cholinergic neuronal (BFCN) dysfunction and degeneration

NEUROPSYCHOPHARMACOLOGY

IF7.1

2021-08-13

OAAI

Alam, John J.; Nixon, Ralph A.

Alzheimer disease 阿尔茨海默病

NATURE REVIEWS DISEASE PRIMERS

IF60.6

2021-05-13

1.1K

OAAI

Knopman, David S.; Amieva, Helene; Petersen, Ronald C.; Chetelat, Gael; Holtzman, David M.; Hyman, Bradley T.; Nixon, Ralph A.; Jones, David T.

Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

CELL REPORTS

IF6.9

2021-04-01

OAAI

Lie, Pearl P. Y.; Yang, Dun-Sheng; Stavrides, Philip; Goulbourne, Chris N.; Zheng, Ping; Mohan, Panaiyur S.; Cataldo, Anne M.; Nixon, Ralph A.

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

CELL REPORTS

IF6.9

2020-11-01

OAAI

Pensalfini, Anna; Kim, Seonil; Subbanna, Shivakumar; Bleiwas, Cynthia; Goulbourne, Chris N.; Stavrides, Philip H.; Jiang, Ying; Lee, Ju-Hyun; Darji, Sandipkumar; Pawlik, Monika; Huo, Chunfeng; Peddy, James; Berg, Martin J.; Smiley, John F.; Basavarajappa, Balapal S.; Nixon, Ralph A.

研究方向