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HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization HTRA1依赖性蛋白酶解诱导年龄相关性视网膜变性并加剧脉络膜新生血管形成 Katschke, Kenneth J.; Truong, Tom; Pham, Victoria; Xi, Hongkang; Tang, Wanjian; Gu, Xiaowu; Teotia, Pooja; Hofmann, Jeffrey W.; Chaney, Shawnta Y.; Kirchhofer, Daniel; Campagne, Menno Van Lookeren; Jeanne, Marion 分享 收藏
Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure 通过NLRC4炎性小体介导的肺成纤维细胞和巨噬细胞的焦亡导致急性呼吸衰竭 Zhang, Yan; Zhang, Guoying; Dong, Brittany; Pandeya, Ankit; Cui, Jian; Valenca, Samuel dos Santos; Yang, Ling; Qi, Jiaqian; Chai, Zhuodong; Wu, Congqing; Kirchhofer, Daniel; Shiroishi, Toshihiko; Khasawneh, Fadi; Tao, Min; Shao, Feng; Waters, Christopher M.; Wei, Yinan; Li, Zhenyu 分享 收藏
Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region Li, Yanjie; Wei, Yuehua; Ultsch, Mark; Li, Wei; Tang, Wanjian; Tombling, Benjamin; Gao, Xinxin; Dimitrova, Yoana; Gampe, Christian; Fuhrmann, Jakob; Zhang, Yingnan; Hannoush, Rami N.; Kirchhofer, Daniel 分享 收藏
Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis Belitskin, Denis; Munne, Pauliina; Pant, Shishir M.; Anttila, Johanna M.; Suleymanova, Ilida; Belitskina, Kati; Kirchhofer, Daniel; Janetka, James; Kasper, Taivo; Jalil, Sami; Pouwels, Jeroen; Tervonen, Topi A.; Klefstrom, Juha 分享 收藏
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration Gerhardy, Stefan; Ultsch, Mark; Tang, Wanjian; Green, Evan; Holden, Jeffrey K.; Li, Wei; Estevez, Alberto; Arthur, Chris; Tom, Irene; Rohou, Alexis; Kirchhofer, Daniel 分享 收藏
Extracellularhistonestrigger Disseminated Intravascular Coagulation By Lytic Cell Death Wu, Congqing; Zhang, Yan; Li, Lan; Pandeya, Ankit; Zhang, Guoying; Cui, Jian; Kirchhofer, Daniel; Wood, Jeremy P.; Smyth, Susan S.; Wei, Yinan; Li, Zhenyu 分享 收藏
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Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif Ultsch, Mark; Holliday, Michael J.; Gerhardy, Stefan; Moran, Paul; Scales, Suzie J.; Gupta, Nidhi; Oltrabella, Francesca; Chiu, Cecilia; Fairbrother, Wayne; Eigenbrot, Charles; Kirchhofer, Daniel 分享 收藏
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge Maun, Henry R.; Vij, Rajesh; Walters, Benjamin T.; Morando, Ashley; Jackman, Janet K.; Wu, Ping; Estevez, Alberto; Chen, Xiaocheng; Franke, Yvonne; Lipari, Michael T.; Dennis, Mark S.; Kirchhofer, Daniel; Ciferri, Claudio; Loyet, Kelly M.; Yi, Tangsheng; Eigenbrot, Charles; Lazarus, Robert A.; Koerber, James T. 分享 收藏
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage AhYoung, Andrew P.; Eckard, Sterling C.; Gogineni, Alvin; Xi, Hongkang; Lin, S. Jack; Gerhardy, Stefan; Cox, Christian; Phung, Qui T.; Hackney, Jason A.; Katakam, Anand Kumar; Reichelt, Mike; Caplazi, Patrick; Manzanillo, Paolo; Zhang, Juan; Roose-Girma, Merone; Tam, Lucinda W.; Newman, Robert J.; Murthy, Aditya; Weimer, Robby M.; Lill, Jennie R.; Lee, Wyne P.; Grimbaldeston, Michele; Kirchhofer, Daniel; Campagne, Menno van Lookeren 分享 收藏
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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy Tom, Irene; Pham, Victoria C.; Katschke, Kenneth J.; Li, Wei; Liang, Wei-Ching; Gutierrez, Johnny; Young, Andrew Ah; Figueroa, Isabel; Eshghi, Shadi Toghi; Lee, ChingWei, V; Kanodia, Jitendra; Snipas, Scott J.; Salvesen, Guy S.; Lai, Phillip; Honigberg, Lee; Campagne, Menno van Lookeren; Kirchhofer, Daniel; Baruch, Amos; Lill, Jennie R. 分享 收藏
Proprotein convertase 7 (PCSK7) reduces apoA-V levels Ashraf, Yahya; Duval, Stephanie; Sachan, Vatsal; Essalmani, Rachid; Susan-Resiga, Delia; Roubtsova, Anna; Hamelin, Josee; Gerhardy, Stefan; Kirchhofer, Daniel; Tagliabracci, Vincent S.; Prat, Annik; Kiss, Robert Scott; Seidah, Nabil G. 分享 收藏
Design of Organo-Peptides As Bipartite PCSK9 Antagonists Burdick, Daniel J.; Skelton, Nicholas J.; Ultsch, Mark; Beresini, Maureen H.; Eigenbrot, Charles; Li, Wei; Zhang, Yingnan; Huy Nguyen; Kong-Beltran, Monica; Quinn, John G.; Kirchhofer, Daniel 分享 收藏
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Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis 炎性体激活通过焦亡触发血液凝结和宿主死亡 Wu, Congqing; Lu, Wei; Zhang, Yan; Zhang, Guoying; Shi, Xuyan; Hisada, Yohei; Grover, Steven P.; Zhang, Xinyi; Li, Lan; Xiang, Binggang; Shi, Jumei; Li, Xiang-An; Daugherty, Alan; Smyth, Susan S.; Kirchhofer, Daniel; Shiroishi, Toshihiko; Shao, Feng; Mackman, Nigel; Wei, Yinan; Li, Zhenyu 分享 收藏
Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice Chen, Daxin; Li, Ke; Them, El-Li; Wei, Lin-Lin; Ma, Ning; Dodd, Philippa C.; Luo, Yi; Kirchhofer, Daniel; McVey, John H.; Darling, Anthony 分享 收藏
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes Hewings, David S.; Heideker, Johanna; Ma, Taylur P.; AhYoung, Andrew P.; El Oualid, Farid; Amore, Alessia; Costakes, Gregory T.; Kirchhofer, Daniel; Brasher, Bradley; Pillow, Thomas; Popovych, Nataliya; Maurer, Till; Schwerdtfeger, Carsten; Forrest, William F.; Yu, Kebing; Flygare, John; Bogyo, Matthew; Wertz, Ingrid E. 分享 收藏
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