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收藏Crystalline Antibody-Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies
Erfani, Amir; Schieferstein, Jeremy M.; Reichert, Paul; Narasimhan, Chakravarthy N.; Pastuskovas, Cinthia; Parab, Vaishali; Simmons, Denarra; Yang, Xiaoyu; Shanker, Apoorv; Hammond, Paula; Doyle, Patrick S.
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收藏Development, validation, and implementation of a robust and quality control-friendly focused peptide mapping method for monitoring oxidation of co-formulated monoclonal antibodies
Xu, Chengdong; Khanal, Sumee; Pierson, Nicholas A.; Quiroz, Jorge; Kochert, Brent; Yang, Xiaoyu; Wylie, David; Strulson, Christopher A.
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收藏Pembrolizumab microgravity crystallization experimentationPembrolizumab微重力结晶实验
Reichert, Paul; Prosise, Winifred; Fischmann, Thierry O.; Scapin, Giovanna; Narasimhan, Chakravarthy; Spinale, April; Polniak, Ray; Yang, Xiaoyu; Walsh, Erika; Patel, Daya; Benjamin, Wendy; Welch, Johnathan; Simmons, Denarra; Strickland, Corey
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收藏Simultaneous monitoring of oxidation, deamidation, isomerization, and glycosylation of monoclonal antibodies by liquid chromatography-mass spectrometry method with ultrafast tryptic digestion
Wang, Yi; Li, Xiaojuan; Liu, Yan-Hui; Richardson, Daisy; Li, Huijuan; Shameem, Mohammed; Yang, Xiaoyu
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收藏Analysis of monoclonal antibody oxidation by simple mixed mode chromatography
Pavon, Jorge Alexander; Li, Xiaojuan; Chico, Steven; Kishnani, Umesh; Soundararajan, Soundara; Cheung, Jason; Li, Huijuan; Richardson, Daisy; Shameem, Mohammed; Yang, Xiaoyu
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收藏Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo
Yang, Xiaoyu; Wang, Fengqiang; Zhang, Ying; Wang, Larry; Antonenko, Svetlana; Zhang, Shuli; Zhang, Yi Wei; Tabrizifard, Mohammad; Ermakov, Grigori; Wiswell, Derek; Beaumont, Maribel; Liu, Liming; Richardson, Daisy; Shameem, Mohammed; Ambrogelly, Alexandre
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收藏Developability studies before initiation of process development Improving manufacturability of monoclonal antibodies
Yang, Xiaoyu; Xu, Wei; Dukleska, Svetlana; Benchaar, Sabrina; Mengisen, Selina; Antochshuk, Valentyn; Cheung, Jason; Mann, Leslie; Babadjanova, Zulfia; Rowand, Jason; Gunawan, Rico; McCampbell, Alexander; Beaumont, Maribel; Meininger, David; Richardson, Daisy; Ambrogelly, Alexandre
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收藏Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography
Orth, Peter; Xiao, Li; Hernandez, Lorraine D.; Reichert, Paul; Sheth, Payal R.; Beaumont, Maribel; Yang, Xiaoyu; Murgolo, Nicholas; Ermakov, Grigori; DiNunzio, Edward; Racine, Fred; Karczewski, Jerzy; Secore, Susan; Ingram, Richard N.; Mayhood, Todd; Strickland, Corey; Therien, Alex G.
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