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收藏Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2
Kaieda, Akira; Takahashi, Masashi; Fukuda, Hiromi; Okamoto, Rei; Morimoto, Shinji; Gotoh, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Sugimoto, Hiroshi; Okada, Kengo; Lane, Weston; Sang, Bi-Ching; Saikatendu, Kumar; Matsunaga, Shinichiro; Miwatashi, Seiji 分享 收藏 Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1Kaieda, Akira; Takahashi, Masashi; Fukuda, Hiromi; Okamoto, Rei; Morimoto, Shinji; Gotoh, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Sugimoto, Hiroshi; Okada, Kengo; Snell, Gyorgy; Bertsch, Ryan; Nguyen, Jasmine; Sang, Bi-Ching; Miwatashi, Seiji 分享 收藏 分享 收藏 Structure-based design, synthesis, and biological evaluation of imidazo [1,2-b]pyridazine-based p38 MAP kinase inhibitorsKaieda, Akira; Takahashi, Masashi; Takai, Takafumi; Goto, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Hamada, Teruki; Shirasaki, Mikio; Okada, Kengo; Snell, Gyorgy; Bragstad, Ken; Sang, Bi-Ching; Uchikawa, Osamu; Miwatashi, Seiji 分享 收藏 Novel approach of fragment-based lead discovery applied to renin inhibitorsTawada, Michiko; Suzuki, Shinkichi; Imaeda, Yasuhiro; Oki, Hideyuki; Snell, Gyorgy; Behnke, Craig A.; Kondo, Mitsuyo; Tarui, Naoki; Tanaka, Toshimasa; Kuroita, Takanobu; Tomimoto, Masaki 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1. Exploration of fused bicyclic core scaffolds using electrostatic potential mapHirayama, Takaharu; Okaniwa, Masanori; Imada, Takashi; Ohashi, Akihiro; Ohori, Momoko; Iwai, Kenichi; Mori, Kouji; Kawamoto, Tomohiro; Yokota, Akihiro; Tanaka, Toshimasa; Ishikawa, Tomoyasu 分享 收藏 Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitorsKawakita, Youichi; Seto, Masaki; Ohashi, Tomohiro; Tamura, Toshiya; Yusa, Tadashi; Miki, Hiroshi; Iwata, Hidehisa; Kamiguchi, Hidenori; Tanaka, Toshimasa; Sogabe, Satoshi; Ohta, Yoshikazu; Ishikawa, Tomoyasu 分享 收藏 Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacyKawakita, Youichi; Miwa, Kazuhiro; Seto, Masaki; Banno, Hiroshi; Ohta, Yoshikazu; Tamura, Toshiya; Yusa, Tadashi; Miki, Hiroshi; Kamiguchi, Hidenori; Ikeda, Yukihiro; Tanaka, Toshimasa; Kamiyama, Keiji; Ishikawa, Tomoyasu 分享 收藏 Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists吡啶氧基苯酰基磺酰胺作为新的，有效的和选择性的过氧化物酶体增殖物激活受体 (PPAR) γ 激动剂的构效关系和关键结构特征Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; Yonemori, Jinichi; Hirose, Hideki; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu 分享 收藏 Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 DiabetesMikami, Satoshi; Kitamura, Shuji; Negoro, Nobuyuki; Sasaki, Shinobu; Suzuki, Masami; Tsujihata, Yoshiyuki; Miyazaki, Takeshi; Ito, Ryo; Suzuki, Nobuhiro; Miyazaki, Junichi; Santou, Takashi; Kanzaki, Naoyuki; Funami, Miyuki; Tanaka, Toshimasa; Yasuma, Tsuneo; Momose, Yu 分享 收藏 Design and Synthesis of Pyrrolo[3,2-d]pyrimidine Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors: Exploration of Novel Back-Pocket BindersKawakita, Youichi; Banno, Hiroshi; Ohashi, Tomohiro; Tamura, Toshiya; Yusa, Tadashi; Nakayama, Akiko; Miki, Hiroshi; Iwata, Hidehisa; Kamiguchi, Hidenori; Tanaka, Toshimasa; Habuka, Noriyuki; Sogabe, Satoshi; Ohta, Yoshikazu; Ishikawa, Tomoyasu 分享 收藏 Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 AgonistsNegoro, Nobuyuki; Sasaki, Shinobu; Ito, Masahiro; Kitamura, Shuji; Tsujihata, Yoshiyuki; Ito, Ryo; Suzuki, Masami; Takeuchi, Koji; Suzuki, Nobuhiro; Miyazaki, Junichi; Santou, Takashi; Odani, Tomoyuki; Kanzaki, Naoyuki; Funami, Miyuki; Tanaka, Toshimasa; Yasuma, Tsuneo; Momose, Yu 分享 收藏 A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamidesRikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Imoto, Hiroshi; Maekawa, Tsuyoshi; Ujikawa, Osamu; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu 分享 收藏 Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor AntagonistsHasui, Tomoaki; Matsunaga, Nobuyuki; Ora, Taiichi; Ohyabu, Norio; Nishigaki, Nobuhiro; Imura, Yoshimi; Igata, Yumiko; Matsui, Hideki; Motoyaji, Takashi; Tanaka, Toshimasa; Habuka, Noriyuki; Sogabe, Satoshi; Ono, Midori; Siedem, Christopher S.; Tang, Tony P.; Gauthier, Cassandra; De Meese, Lisa A.; Boyd, Steven A.; Fukumoto, Shoji 分享 收藏 Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine ScaffoldIshikawa, Tomoyasu; Seto, Masaki; Banno, Hiroshi; Kawakita, Youichi; Oorui, Mami; Taniguchi, Takahiko; Ohta, Yoshikazu; Tamura, Toshiya; Nakayama, Akiko; Miki, Hiroshi; Kamiguchi, Hidenori; Tanaka, Toshimasa; Habuka, Noriyuki; Sogabe, Satoshi; Yano, Jason; Aertgeerts, Kathleen; Kamiyama, Keiji 分享 收藏 Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancerKaku, Tomohiro; Hitaka, Takenori; Ojida, Akio; Matsunaga, Nobuyuki; Adachi, Mari; Tanaka, Toshimasa; Hara, Takahito; Yamaoka, Masuo; Kusaka, Masami; Okuda, Teruaki; Asahi, Satoru; Furuya, Shuichi; Tasaka, Akihiro 分享 收藏 
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