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L

Leen Wolfs

Flanders Institute for Biotechnology
H指数:12
被引数:3,285

个人简介

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工作经历

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荣誉奖项

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Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo

可诱导的人胚囊髓系祖细胞模型髓系发育并实现体内组织驻留巨噬细胞替代

Developmental Cell
IF8.7
2026-10-060
OAAI
Anna Martinez-Muriana; Nicola Fattorelli; Leen Wolfs; Lena Jutz; Emanuela Pasciuto; Heidi Denton; Maxim van Hoek; Jessie Premereur; Gaia Zen; Baukje Bijnens; Alma Mohebiany; Tim Meese; Arthi Shanmugavadivu; V. Hugh Perry; Bart De Strooper; Renzo Mancuso
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia

阿尔茨海默病治疗药物Lecanemab通过在微胶质细胞中诱导一种淀粉样蛋白清除程序来减轻Aβ病理性变化

Nature Neuroscience
IF20
2025-11-240
OAAI
Giulia Albertini; Magdalena Zielonka; Marie-Lynn Cuypers; An Snellinx; Ciana Xu; Suresh Poovathingal; Marta Wojno; Kristofer Davie; Veerle van Lieshout; Katleen Craessaerts; Leen Wolfs; Emanuela Pasciuto; Tom Jaspers; Katrien Horré; Lurgarde Serneels; Mark Fiers; Maarten Dewilde; Bart De Strooper
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia

来自星形胶质细胞的APOE在APOE缺陷的小胶质细胞中恢复了阿尔茨海默氏病的a β 病理学和DAM样反应

EMBO MOLECULAR MEDICINE
IF8.3
2024-11-111
PRE
Preman, Pranav; Moechars, Daan; Fertan, Emre; Wolfs, Leen; Serneels, Lutgarde; Shah, Disha; Lamote, Jochen; Poovathingal, Suresh; Snellinx, An; Mancuso, Renzo; Balusu, Sriram; Klenerman, David; Arranz, Amaia M.; Fiers, Mark; De Strooper, Bart
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease

星形胶质细胞钙功能障碍导致阿尔茨海默氏病的早期网络功能亢进

CELL REPORTS
IF6.9
2022-08-0156
OAAI
Shah, Disha; Gsell, Willy; Wahis, Jerome; Luckett, Emma S.; Jamoulle, Tarik; Vermaercke, Ben; Preman, Pranav; Moechars, Daan; Hendrickx, Veronique; Jaspers, Tom; Craessaerts, Katleen; Horre, Katrien; Wolfs, Leen; Fiers, Mark; Holt, Matthew; Thal, Dietmar Rudolf; Callaerts-Vegh, Zsuzsanna; D'Hooge, Rudi; Vandenberghe, Rik; Himmelreich, Uwe; Bonin, Vincent; De Strooper, Bart
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease
CELL STEM CELL
IF20.4
2021-10-0197
OAAI
Walgrave, Hannah; Balusu, Sriram; Snoeck, Sarah; Vanden Eynden, Elke; Craessaerts, Katleen; Thrupp, Nicky; Wolfs, Leen; Horre, Katrien; Fourne, Yannick; Ronisz, Alicja; Silajdzic, Edina; Penning, Amber; Tosoni, Giorgia; Callaerts-Vegh, Zsuzsanna; D'Hooge, Rudi; Thal, Dietmar Rudolf; Zetterberg, Henrik; Thuret, Sandrine; Fiers, Mark; Frigerio, Carlo Sala; De Strooper, Bart; Salta, Evgenia
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2015-10-1463
PREAI
Huang, Yunhong; Skwarek-Maruszewska, Aneta; Horre, Katrien; Vandewyer, Elke; Wolfs, Leen; Snellinx, An; Saito, Takashi; Radaelli, Enrico; Corthout, Nikky; Colombelli, Julien; Lo, Adrian C.; Van Aerschot, Leen; Callaerts-Vegh, Zsuzsanna; Trabzuni, Daniah; Bossers, Koen; Verhaagen, Joost; Ryten, Mina; Munck, Sebastian; D'Hooge, Rudi; Swaab, Dick F.; Hardy, John; Saido, Takaomi C.; De Strooper, Bart; Thathiah, Amantha

研究方向

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B
Bart De Strooper
H 指数:142论文数:690被引数:7.7万
R
Renzo Mancuso
H 指数:33论文数:89被引数:8,293
M
Mark Fiers
H 指数:42论文数:112被引数:1.3万
N
Nicola Fattorelli
H 指数:10论文数:19被引数:2,233
K
Katrien Horré
H 指数:24论文数:68被引数:4,724
S
Suresh Poovathingal
H 指数:35论文数:141被引数:6,471
R
Rudi D’Hooge
H 指数:60论文数:264被引数:1.3万
K
Katleen Craessaerts
H 指数:33论文数:73被引数:1.1万
L
Lutgarde Serneels
H 指数:44论文数:118被引数:8,435
S
Sriram Balusu
H 指数:22论文数:51被引数:3,525