未登录Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist别构诱导雌激素受体配体结合域四聚化由一种独特的完全雌激素受体拮抗剂介导
Fink, Emma C.; Chawla, Reena; Hancock, Govinda R.; Wells, Kylie S.; Barratt, Susanna; Myles, David. C.; Pena, Guadalupe; Robello, Brandon W.; Hearn, Brian R.; Fanning, Sean W. .png)
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收藏Combining palazestrant, a CERAN, and everolimus, an mTOR inhibitor, enhances tumor suppression in ER+/HER2-breast cancer modelsBarratt, S.; Palanisamy, G.; Robello, B.; Pena, G.; Ng, R.; Myles, D. 分享 收藏 Combining OP-3136, a KAT6 inhibitor, with endocrine therapy and CDK4/6 inhibitor enhances anti-tumor activity in ER+/HER2-breast cancer modelsPalanisamy, G.; Barratt, S.; Hope, C.; Robello, B.; Pena, G.; Goyal, M.; Venkateshappa, C.; Ng, R.; Ramachandra, M.; Myles, D. 分享 收藏 Combining palazestrant, a CERAN, and capivasertib, a pan-AKT inhibitor, enhances tumor suppression in ER+/HER2-breast cancer modelsBarratt, S.; Palanisamy, G.; Robello, B.; Pena, G.; Ng, R.; Myles, D. 分享 收藏 Palazestrant (OP-1250), A Complete Estrogen Receptor Antagonist, Inhibits Wild-type and Mutant ER-positive Breast Cancer Models as Monotherapy and in CombinationParisian, Alison D.; Barratt, Susanna A.; Hodges-Gallagher, Leslie; Ortega, Fabian E.; Pena, Guadalupe; Sapugay, Judevin; Robello, Brandon; Sun, Richard; Kulp, David; Palanisamy, Gopinath S.; Myles, David C.; Kushner, Peter J.; Harmon, Cyrus L. 分享 收藏 The discovery of potent KAT6 inhibitors that demonstrate anti-tumor activity in preclinical models of ER plus breast cancerPalanisamy, Gopinath S.; Venkateshappa, Chandregowda; Goyal, Megha; Barrett, Susanna A.; Heam, Brian R.; Daginakatte, Girish; Aravind, A. B.; Samiulla, D. S.; Bera, Kalisankar; Sangeetha, S.; Khare, Leena; Parisian, Alison D.; Heerding, Dirk A.; Ng, Raymond A.; Harmon, Cyrus L.; Samajdar, Susanta; Ramachandra, Murali; Myles, David C. 分享 收藏 The complete estrogen receptor antagonist OP-1250 can combine with HER2 inhibition to inhibit estrogen receptor-driven cellular proliferation and shrink xenograft tumors in ER+/HER2+breast cancer modelsParisian, Alison D.; Hodges-Gallagher, Leslie; Sun, Richard; Barratt, Susanna; Palanisamy, Gopinath S.; Lawrence, Julia; Klein, Pamela; Myles, David C.; Harmon, Cyrus L.; Kushner, Peter J. 分享 收藏 Preliminary data from a phase I/II, multicenter, dose escalation study of OP-1250, an oral CERAN/SERD, in subjects with advanced and/or metastatic estrogen receptor (ER)-positive, HER2-negative breast cancerPatel, Manish; Alemany, Carlos; Mitri, Zahi; Makower, Della; Borges, Virginia; Sparano, Joseph; Trinh Le; Klein, Pamela; Lawrence, Julia; Kushner, Peter; Faltaos, Demiana; Harmon, Cyrus; Myles, David; Zujewski, JoAnne; Hamilton, Erika 分享 收藏 分享 收藏 分享 收藏 Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activityFanning, S. W.; Hodges-Gallagher, L.; Myles, D. C.; Sun, R.; Fowler, C. E.; Plant, I. N.; Green, B. D.; Harmon, C. L.; Greene, G. L.; Kushner, P. J. 分享 收藏 分享 收藏 分享 收藏 Structure-Activity Relationships of 9-Substituted-9-Dihydroerythromycin-Based Motilin Agonists: Optimizing for Potency and SafetyShaw, Simon J.; Chen, Yue; Zheng, Hao; Fu, Hong; Burlingame, Mark A.; Marquez, Saul; Li, Yong; Claypool, Mark; Carreras, Christopher W.; Crumb, William; Hardy, Dwight J.; Myles, David C.; Liu, Yaoquan 分享 收藏 分享 收藏 Investigating amine derivatives of ambruticin VS-5 and VS-4Tian, Zong-Qiang; Wang, Zhan; Xu, Yuan; Tran, Chau Q.; Myles, David C.; Zhong, Ziyang; Simmons, Jessica; Vetcher, Leandro; Katz, Leonard; Li, Yong; Shaw, Simon J. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolideSmith, AB; Freeze, BS; LaMarche, MJ; Hirose, T; Brouard, I; Rucker, PV; Xian, M; Sundermann, KF; Shaw, SJ; Burlingame, MA; Horwitz, SB; Myles, DC 分享 收藏 
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