Efstratios Stratikos - Publications, H-index & Citations

Efstratios Stratikos

demokritos

41H指数

145论文数

4.2K被引数

收录论文 78

发表时间

Automated Molecular Design in BRADSHAW; Applied to the Optimization of ERAP1 Inhibitors BRADSHAW中的自动化分子设计及其在ERAP1抑制剂优化中的应用

Journal of Medicinal Chemistry

IF6.8

2026-04-13

PREAI

Robert P. Law; Ian D. Wall; Richard Lonsdale; Ross P. Hryczanek; Daniel Barker; Tim N. Barrett; Rino A. Bit; John J. Coward; Matthew W. Gray; Darren V. S. Green; Callum J. Hall; Ashley P. Hancock; Carl Haslam; David J. Hirst; Heather F. Hryczanek; Jonathan P. Hutchinson; Semra Kitchen; David Marcus; Jared Marklew; Joseph Mason; Nicholas D. Measom; Margarete Neu; Simon Peace; Alex Phillipou; Stephen D. Pickett; Peter Pogány; James Rowedder; Paul Rowland; Paul Scott-Stevens; Gail A. L. Seal; Hester Sheehan; Efstratios Stratikos; Chloe Tayler; Jonathan A. Taylor; Christopher P. Tinworth; Giovanni Vitulli

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes ERAP1等位基因2和10差异调控黑色素细胞的免疫肽组

Immunology

IF5

2025-10-23

OAAI

Martha Nikopaschou; Martina Samiotaki; Anna Kannavou; Nikolaos V. Angelis; Ourania Tsitsilonis; George Panayotou; Efstratios Stratikos

Discovery of Novel Allosteric Inhibitor Hits for Insulin-Regulated Aminopeptidase Provides Insights on Enzymatic Mechanism 新型别构抑制剂命中胰岛素调控氨肽酶的发现为酶促机制提供了见解

ACS OMEGA

IF4.3

2025-04-23

OAAI

Georgaki, Galateia; Koutroumpa, Nikoletta-Maria; Lagarias, Panagiotis; Afantitis, Antreas; Papakyriakou, Athanasios; Stratikos, Efstratios

Dantrolene is an HDL-associated paraoxonase-1 activator with immunosuppressive and atheroprotective properties

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

IF3.3

2025-03-01

PREAI

Dedemadi, Anastasia-Georgia; Sevdali, Eirini; Georgiadou, Daphne; Valanti, Eftaxia-Konstantina; Neofotistou-Themeli, Elpida; Chanis, Theodoros; Goutakoli, Panagiota; Thymiakou, Efstathia; Drakos, Elias; Christopoulou, Georgia; Bournazos, Stavros; Constantoulakis, Pantelis; Verginis, Panayotis; Kardassis, Dimitris; Stratikos, Efstratios; Sidiropoulos, Prodromos; Chroni, Angeliki

Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-11-06

OAAI

Hryczanek, Ross P.; Hackett, Andrew S.; Rowland, Paul; Chung, Chun-wa; Convery, Maire A.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Kitchen, Semra; Korczynska, Justyna; Law, Robert P.; Lea, Jonathan D.; Liddle, John; Lonsdale, Richard; Neu, Margarete; Nickels, Leng; Phillipou, Alex; Rowedder, James E.; Schneck, Jessica L.; Scott-Stevens, Paul; Sheehan, Hester; Tayler, Chloe L.; Temponeras, Ioannis; Tinworth, Christopher P.; Walker, Ann L.; Wojno-Picon, Justyna; Young, Robert J.; Lindsay, David M.; Stratikos, Efstratios

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-10-18

OAAI

Georgaki, Galateia; Mpakali, Anastasia; Trakada, Myrto; Papakyriakou, Athanasios; Stratikos, Efstratios

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism (vol 12, 5302, 2021)与结构域闭合和底物结合相关的构象动力学解释了ERAP1变构调节机制 (第12卷，5302卷，2021卷)

NATURE COMMUNICATIONS

IF15.7

2023-03-20

OAAI

Maben, Zachary; Arya, Richa; Georgiadis, Dimitris; Stratikos, Efstratios; Stern, Lawrence J.

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2022-08-19

OAAI

Camberlein, Virgyl; Fleau, Charlotte; Sierocki, Pierre; Li, Lenong; Gealageas, Ronan; Bosc, Damien; Guillaume, Valentin; Warenghem, Sandrine; Leroux, Florence; Rosell, Melissa; Cheng, Keguang; Medve, Laura; Prigent, Mathilde; Decanter, Myriam; Piveteau, Catherine; Biela, Alexandre; Eveque, Maxime; Dumont, Julie; Mpakali, Anastasia; Giastas, Petros; Herledan, Adrien; Couturier, Cyril; Haupenthal, Joerg; Lesire, Laetitia; Hirsch, Anna K. H.; Deprez, Benoit; Stratikos, Efstratios; Bouvier, Marlene; Deprez-Poulain, Rebecca

Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-07-14

OAAI

Vourloumis, Dionisios; Mavridis, Ioannis; Athanasoulis, Alexandros; Temponeras, Ioannis; Koumantou, Despoina; Giastas, Petros; Mpakali, Anastasia; Magrioti, Victoria; Leib, Jacqueline; van Endert, Peter; Stratikos, Efstratios; Papakyriakou, Athanasios

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-04-20

OAAI

Papakyriakou, Athanasios; Mpakali, Anastasia; Stratikos, Efstratios

Inhibitor-Dependent Usage of the S1′ Specificity Pocket of ER Aminopeptidase 2

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-01-13

OAAI

Mpakali, Anastasia; Georgiadis, Dimitris; Stratikos, Efstratios; Giastas, Petros

Tunable Hydrogels with Improved Viscoelastic Properties from Hybrid Polypeptides

MACROMOLECULES

IF5.2

2021-11-16

PREAI

Skoulas, Dimitrios; Mangiapia, Gaetano; Parisi, Daniele; Kasimatis, Maria; Glynos, Emmanouil; Stratikos, Efstratios; Vlassopoulos, Dimitris; Frielinghaus, Henrich; Iatrou, Hermis

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-11-01

OAAI

Stamatakis, George; Samiotaki, Martina; Temponeras, Ioannis; Panayotou, George; Stratikos, Efstratios

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism 与结构域闭合和底物结合相关的构象动力学解释了ERAP1变构调控机制

NATURE COMMUNICATIONS

IF15.7

2021-09-06

OAAI

Maben, Zachary; Arya, Richa; Georgiadis, Dimitris; Stratikos, Efstratios; Stern, Lawrence J.

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

SCIENTIFIC REPORTS

IF3.9

2021-08-13

OAAI

Mavridis, George; Mpakali, Anastasia; Zoidakis, Jerome; Makridakis, Manousos; Vlahou, Antonia; Kaloumenou, Eleni; Ziotopoulou, Angeliki; Georgiadis, Dimitris; Papakyriakou, Athanasios; Stratikos, Efstratios

Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

PHARMACEUTICALS

IF4.8

2021-06-18

OAAI

Temponeras, Ioannis; Chiniadis, Lykourgos; Papakyriakou, Athanasios; Stratikos, Efstratios

Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2021-04-23

OAAI

Chai, Siew Yeen; Gutierrez-de-Teran, Hugo; Stratikos, Efstratios

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-02-25

OAAI

Venema, Wouter J.; Hiddingh, Sanne; de Boer, Joke H.; Claas, Frans H. J.; Mulder, Arend; den Hollander, Anneke, I; Stratikos, Efstratios; Sarkizova, Siranush; van der Veken, Lars T.; Janssen, George M. C.; van Veelen, Peter A.; Kuiper, Jonas J. W.

A Carbodiimide-Mediated P-C Bond-Forming Reaction: Mild Amidoalkylation of P-Nucleophiles by Boc-Aminals

ORGANIC LETTERS

IF5

2021-02-22

PREAI

Kokkala, Paraskevi; Rajeshkumar, Thayalan; Mpakali, Anastasia; Stratikos, Efstratios; Vogiatzis, Konstantinos D.; Georgiadis, Dimitris

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Hutchinson, Jonathan P.; Temponeras, Ioannis; Kuiper, Jonas; Cortes, Adrian; Korczynska, Justyna; Kitchen, Semra; Stratikos, Efstratios

研究方向