未登录 LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models LOXO-783: 一种有效的，高度突变的选择性和脑渗透变构PI3Kα H1047R抑制剂与临床前PI3Kα H1047R-mutant乳腺癌模型的护理标准 (SOC) 联合治疗 Puca, Loredana; Dowless, Michele S.; Perez-Ferreiro, Carmen M.; Ortiz-Ruiz, Maria Jesus; Donoho, Gregory P.; Capen, Andrew; Huber, Lysiane; Bogner, Sarah M.; Fei, Dongling; Manro, Jason R.; Yu, Chun Ping; Xu, Wei Guo; Wang, Rui; Chen, Shuang; Hicks, Mark A.; Zolfaghari, Parisa; Faber, Andrew; Gilmour, Raymond; Ramstetter, Monica D.; Chang, Matthew T.; Lallena, Maria Jose; Gong, Xuequian; Hyman, David M.; Smyth, Lillian M.; Brandhuber, Barbara J.; Taylor, Barry S.; Klippel, Anke 分享 收藏
LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML) Salama, Vivian; Brooks, Nathan; Skwarska, Anna; Kays, Lisa; Milligan, Paul; Newell, Katherine; Roth, Kenneth; Geeganage, Sandaruwan; Gilmour, Raymond; Chan, Steven M.; Sarry, Jean-Emmanuel; Sabatier, Mary; DiNardo, Courtney; Konopleva, Marina 分享 收藏
Tryptophan Metabolism Plays a Central Role in Immunosuppression Geeganage, Sandaruwan; Sams, Lillian; Henry, James; Dorsey, Frank; Roth, Kenneth; Nikolayev, Alexander; Benhadji, Karim; Gilmour, Raymond; Cerezo, Ana; Peregrina, Sandra; Martinez-del Hoyo, Gloria; Campos-Olivas, Ramon; Manuel Funes, Juan; Diezma, Laura; Velasco-Miguel, Susana 分享 收藏
Investigating the expression of indolamine deoxygenase I (IDO1) and other immune markers in tissue microarrays Cerezo, Ana; Martinez-del Hoyo, Gloria; Peregrina, Sandra; Mondejar, Tamara; Caleiras, Eduardo; Gonzalez, Patricia; Lospitao, Eva; Hernandez-Tiedra, Sonia; Diezma, Laura; Casas, Estela; Dorsey, Frank; Benhadji, Karim; Gilmour, Raymond; Geeganage, Sandaruwan; Velasco, Susana 分享 收藏
Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1) Brooks, Nathan; DeWalt, Robin; Boulet, Serge; Lu, ZhaoHai; Kays, Lisa; Cavitt, Rachel; Gomez, Sandra; Strelow, John; Milligan, Paul; Roth, Kenneth; Bauer, Renato; Antonysamy, Stephen; Hahn, Patric; Rankovic, Zoran; McCann, Denis; Mo, Gary; Tiu, Ramon; Burkholder, Timothy; Geeganage, Sandaruwan; Gilmour, Raymond 分享 收藏
Characterization of the oncogenic properties of mutant isocitrate dehydrogenase 1 (IDH1R132H) in human primary cells Barradas, M.; Diezma, L.; Perez-Ferreiro, C. M.; Cerezo, A.; Lospitao, E.; Peregrina, S.; Jimenez, S.; Brooks, N. A.; Torres, R.; Geeganage, S.; Gilmour, R.; Velasco-Miguel, S. 分享 收藏
Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity Campbell, Robert M.; Anderson, Bryan D.; Brooks, Nathan A.; Brooks, Harold B.; Chan, Edward M.; De Dios, Alfonso; Gilmour, Raymond; Graff, Jeremy R.; Jambrina, Enrique; Mader, Mary; McCann, Denis; Na, Songqing; Parsons, Stephen H.; Pratt, Susan E.; Shih, Chuan; Stancato, Louis F.; Starling, James J.; Tate, Courtney; Velasco, Juan A.; Wang, Yong; Ye, Xiang S. 分享 收藏
分享 收藏
The Critical Role of IL-1 Receptor-Associated Kinase 4-Mediated NF-κB Activation in Modified Low-Density Lipoprotein-Induced Inflammatory Gene Expression and Atherosclerosis Kim, Tae Whan; Febbraio, Maria; Robinet, Peggy; DuGar, Brandon; Greene, Diane; Cerny, Anna; Latz, Eicke; Gilmour, Raymond; Staschke, Kirk; Chisolm, Guy; Fox, Paul L.; DiCorleto, Paul E.; Smith, Jonathan D.; Li, Xiaoxia 分享 收藏
IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease Staschke, Kirk A.; Dong, Sucai; Saba, Joy; Zhao, Jingyong; Brooks, Nathan A.; Hepburn, Deena L.; Xia, Jinqi; Gulen, Muhammet F.; Kang, Zizhen; Altuntas, Cengiz Z.; Tuohy, Vincent K.; Gilmour, Raymond; Li, Xiaoxia; Na, Songqing 分享 收藏
Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NFκB activation Xiao, Hui; Qian, Wen; Staschke, Kirk; Qian, Youcun; Cui, Grace; Deng, Li; Ehsani, Mariam; Wang, Xiliang; Qian, Yue-Wei; Chen, Zhijian J.; Gilmour, Raymond; Jiang, Zhengfan; Li, Xiaoxia 分享 收藏
A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity IRAK4激酶活性在Toll样受体介导的先天免疫中的关键作用 Kim, Tae Whan; Staschke, Kirk; Bulek, Katarzyna; Yao, Jianhong; Peters, Kristi; Oh, Keun-Hee; Vandenburg, Yvonne; Xiao, Hui; Qian, Wen; Hamilton, Tom; Min, Booki; Sen, Ganes; Gilmour, Raymond; Li, Xiaoxia 分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
.png){kind=icon}
.png)
CANCER RESEARCH.png)
.png){kind=icon}
分享.png){kind=icon}
收藏