David E. Cane - Publications, H-index & Citations

David E. Cane

Brown University

81H指数

433论文数

2.4W被引数

收录论文 152

发表时间

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2018-05-15

OAAI

Li, Xiuyuan; Sevillano, Natalia; La Greca, Florencia; Deis, Lindsay; Liu, Yu-Chen; Deller, Marc C.; Mathews, Irimpan I.; Matsui, Tsutomu; Cane, David E.; Craik, Charles S.; Khosla, Chaitan

Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2017-09-27

OAAI

Shah, Dhara D.; You, Young-Ok; Cane, David E.

Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2017-07-07

OAAI

Xie, Xinqiang; Garg, Ashish; Khosla, Chaitan; Cane, David E.

Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2017-04-25

OAAI

Xie, Xinqiang; Khosla, Chaitan; Cane, David E.

Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2017-02-14

OAAI

Xie, Xinqiang; Garg, Ashish; Khosla, Chaitan; Cane, David E.

Structure and mechanism of assembly line polyketide synthases

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2016-12-01

127

OAAI

Robbins, Thomas; Liu, Yu-Chen; Cane, David E.; Khosla, Chaitan

The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2016-09-16

OAAI

Duan, Lian; Jogl, Gerwald; Cane, David E.

Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-07-01

OAAI

Klaus, Maja; Ostrowski, Matthew P.; Austerjost, Jonas; Robbins, Thomas; Lowry, Brian; Cane, David E.; Khosla, Chaitan

A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases

ACS CENTRAL SCIENCE

IF10.4

2016-01-06

OAAI

Lowry, Brian; Li, Xiuyuan; Robbins, Thomas; Cane, David E.; Khosla, Chaitan

Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase

ACS CHEMICAL BIOLOGY

IF3.8

2016-01-06

OAAI

Chen, Mengbin; Chou, Wayne K. W.; Toyomasu, Tomonobu; Cane, David E.; Christianson, David W.

Terpene synthases are widely distributed in bacteria

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-12-22

387

OAAI

Yamada, Yuuki; Kuzuyama, Tomohisa; Komatsu, Mamoru; Shin-ya, Kazuo; Omura, Satoshi; Cane, David E.; Ikeda, Haruo

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2014-07-10

OAAI

Garg, Ashish; Xie, Xinqiang; Keatinge-Clay, Adrian; Khosla, Chaitan; Cane, David E.

Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2014-03-11

OAAI

Lin, Hsiao-Ching; Tsunematsu, Yuta; Dhingra, Sourabh; Xu, Wei; Fukutomi, Manami; Chooi, Yit-Heng; Cane, David E.; Calvo, Ana M.; Watanabe, Kenji; Tang, Yi

In Vitro Reconstitution and Analysis of the 6-Deoxyerythronolide B Synthase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2013-11-01

OAAI

Lowry, Brian; Robbins, Thomas; Weng, Chih-Hisang; O'Brien, Robert V.; Cane, David E.; Khosla, Chaitan

Coupled Methyl Group Epimerization and Reduction by Polyketide Synthase Ketoreductase Domains. Ketoreductase-Catalyzed Equilibrium Isotope Exchange

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2013-10-29

OAAI

Garg, Ashish; Khosla, Chaitan; Cane, David E.

Stereochemistry of Reductions Catalyzed by Methyl-Epimerizing Ketoreductase Domains of Polyketide Synthases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2013-05-13

OAAI

You, Young-Ok; Khosla, Chaitan; Cane, David E.

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

ACS SYNTHETIC BIOLOGY

IF3.9

2013-01-17

214

OAAI

Komatsu, Mamoru; Komatsu, Kyoko; Koiwai, Hanae; Yamada, Yuuki; Kozone, Ikuko; Izumikawa, Miho; Hashimoto, Junko; Takagi, Motoki; Omura, Satoshi; Shin-ya, Kazuo; Cane, David E.; Ikeda, Haruo

Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding Pocket

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2012-07-11

OAAI

Harvey, Colin J. B.; Puglisi, Joseph D.; Pande, Vijay S.; Cane, David E.; Khosla, Chaitan

Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2012-07-09

OAAI

Zu, Liansuo; Xu, Meimei; Lodewyk, Michael W.; Cane, David E.; Peters, Reuben J.; Tantillo, Dean J.