Sharath S. Hegde - Publications, H-index & Citations

Sharath S. Hegde

theravance

28H指数

99论文数

2.9K被引数

收录论文 39

发表时间

Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-12-03

OAAI

McKinnell, R. Murray; Fatheree, Paul; Choi, Seok-Ki; Gendron, Roland; Jendza, Keith; Blair, Brooke Olson; Budman, Joe; Hill, Craig M.; Hegde, Laxminarayan G.; Yu, Cecile; McConn, Donavon; Hegde, Sharath S.; Marquess, Daniel G.; Klein, Uwe

Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy

JOURNAL OF INFLAMMATION-LONDON

IF4.1

2017-12-06

OAAI

Beattie, David T.; Pulido-Rios, M. Teresa; Shen, Fei; Ho, Melissa; Situ, Eva; Tsuruda, Pam R.; Brassil, Patrick; Kleinschek, Melanie; Hegde, Sharath

Duration by Design: Discovery of Revefenacin, the First-in-Class Nebulized Once-Daily Bronchodilator for the Treatment of Patients With COPD

CHEST

IF8.6

2016-10-01

OAAI

Ji, Yuhua; Husfeld, Craig; Pulido-Rios, Teresa; McNamara, Alexander; Obedencio, Glenmar P.; Baldwin, Mike; Bourdet, David; Hegde, Sharath; Mammen, Mathai; Moran, Edmund

Are blood vessels a target to treat lower urinary tract dysfunction?血管是治疗下尿路功能障碍的靶点吗？

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2015-05-31

OAAI

Michel, Martin C.; Chess-Williams, Russ; Hegde, Sharath S.

Discovery of (R)-1-(34(2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-02-09

OAAI

Hughes, Adam D.; Chen, Yan; Hegde, Sharath S.; Jasper, Jeffrey R.; Jaw-Tsai, Sarah; Lee, Tae-Weon; McNamara, Alexander; Pulido-Rios, M. Teresa; Steinfeld, Tod; Mammen, Mathai

Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

IF3.8

2014-11-09

OAAI

Hegde, Sharath S.; Janc, James W.

Pharmacologic Characterization of GSK-961081 (TD-5959), a First-in-Class Inhaled Bifunctional Bronchodilator Possessing Muscarinic Receptor Antagonist and β2-Adrenoceptor Agonist Properties

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2014-10-01

PREAI

Hegde, Sharath S.; Hughes, Adam D.; Chen, Yan; Steinfeld, Tod; Jasper, Jeffrey R.; Lee, Tae-Weon; McNamara, Alexander; Martin, William J.; Pulido-Rios, M. Teresa; Mammen, Mathai

Combating the growing problem of methicillin-resistant Staphylococcus aureus:: do the newer antibiotics represent a better alternative to vancomycin?

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

IF3.8

2014-01-10

PREAI

Chambers, Henry F.; Hegde, Sharath S.

An invitation for comprehensive single-compound reviews on the pharmacological properties of newly launched drugs

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2013-09-22

OAAI

Michel, Martin C.; Hegde, Sharath; Hoyer, Daniel; Trifilieff, Alexander

In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2013-08-01

PREAI

Pulido-Rios, M. T.; McNamara, A.; Obedencio, G. P.; Ji, Y.; Jaw-Tsai, S.; Martin, W. J.; Hegde, S. S.

The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2013-03-13

PREAI

Armstrong, Scott R.; Campbell, Christina B.; Richardson, Carrie L.; Vickery, Ross G.; Tsuruda, Pamela R.; Long, Daniel D.; Hegde, Sharath S.; Beattie, David T.

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA)

PULMONARY PHARMACOLOGY & THERAPEUTICS

IF2.8

2012-10-01

PREAI

McNamara, Alexander; Steinfeld, Tod; Pulido-Rios, Maria Teresa; Stangeland, Eric; Hegde, Sharath S.; Mammen, Mathai; Martin, William J.

RS-39604 - A POTENT, SELECTIVE AND ORALLY-ACTIVE 5-HT4 RECEPTOR ANTAGONIST

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2012-07-19

OAAI

HEGDE, SS; BONHAUS, DW; JOHNSON, LG; LEUNG, E; CLARK, RD; EGLEN, RM

Telavancin Pharmacokinetics and Pharmacodynamics in Patients with Complicated Skin and Skin Structure Infections and Various Degrees of Renal Function

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-04-01

OAAI

Lodise, T. P.; Butterfield, J. M.; Hegde, S. S.; Samara, E.; Barrier, S. L.

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-03-01

OAAI

Hegde, Sharath S.; Okusanya, Olanrewaju O.; Skinner, Robert; Shaw, Jeng-Pyng; Obedencio, Glenmar; Ambrose, Paul G.; Blais, Johanne; Bhavnani, Sujata M.

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2009-03-01

PREAI

McNamara, Alexander; Pulido-Rios, Maria Teresa; Sweazey, Shelley; Obedencio, Glenmar P.; Thibodeaux, Harold; Renner, Travis; Armstrong, Scott R.; Steinfeld, Tod; Hughes, Adam D.; Wilson, Richard D.; Jasper, Jeffrey R.; Mammen, Mathai; Hegde, Sharath S.

Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2009-02-17

OAAI

Hegde, Sharath S.; Difuntorum, Stacey; Skinner, Robert; Trumbull, Justin; Krause, Kevin M.

Functional role of M-2 and M-3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo M-2和M-3毒蕈碱受体在体外和体内大鼠膀胱中的功能作用

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-02-11

260

OAAI