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First-in-human phase I dose escalation study of ALG.APV-527, a 5T4 tumor antigen-conditional 4-1BB bispecific antibody, in patients with advanced solid tumors, demonstrates positive safety, signals of biological activity and patients with lasting stable disease ALG.APV-527（一种5T4肿瘤抗原条件性4-1BB双特异性抗体）在晚期实体瘤患者中的首次人体I期剂量递增研究，显示出良好的安全性、生物学活性信号以及持久稳定疾病的患者。 Marron, T.; Rosen, S.; Orr, D.; Powderly, J., II; Khaskhely, N.; Bonham, L.; Nelson, M.; Taromino, C.; Taylor, D.; Kumer, J.; Ellmark, P.; Fritzell, S.; Ambarkhane, S. V.; Huebner, D.; Alahmadi, A. 分享 收藏
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Reconfiguration and loss of peritubular capillaries in chronic kidney disease Gaupp, Charlotte; Schmid, Benjamin; Tripal, Philipp; Edwards, Aurelie; Daniel, Christoph; Zimmermann, Stefan; Goppelt-Struebe, Margarete; Willam, Carsten; Rosen, Seymour; Schley, Gunnar 分享 收藏
In cis benign SOCS1 variants linked to enhanced interferon signaling and autoimmunity Du, Yan; Brodeur, Kailey E.; Hsu, Evan; Chen, Liang; Chen, Qian; Liu, Meng; Cheng, Qi; Rosen, Seymour; Michniacki, Thomas F.; Chou, Janet; Lo, Mindy S.; Platt, Craig D.; Lee, Pui Y. 分享 收藏
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Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice Majmundar, Amar J.; Buerger, Florian; Forbes, Thomas A.; Klambt, Verena; Schneider, Ronen; Deutsch, Konstantin; Kitzler, Thomas M.; Howden, Sara E.; Scurr, Michelle; Tan, Ker Sin; Krzeminski, Mickael; Widmeier, Eugen; Braun, Daniela A.; Lai, Ethan; Ullah, Ihsan; Amar, Ali; Kolb, Amy; Eddy, Kaitlyn; Chen, Chin Heng; Salmanullah, Daanya; Dai, Rufeng; Nakayama, Makiko; Ottlewski, Isabel; Kolvenbach, Caroline M.; Onuchic-Whitford, Ana C.; Mao, Youying; Mann, Nina; Nabhan, Marwa M.; Rosen, Seymour; Forman-Kay, Julie D.; Soliman, Neveen A.; Heilos, Andreas; Kain, Renate; Aufricht, Christoph; Mane, Shrikant; Lifton, Richard P.; Shril, Shirlee; Little, Melissa H.; Hildebrandt, Friedhelm 分享 收藏
Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease Charlton, Jennifer R.; Tan, Weizhen; Daouk, Ghaleb; Teot, Lisa; Rosen, Seymour; Bennett, Kevin M.; Cwiek, Aleksandra; Nam, Sejin; Emma, Francesco; Jouret, Francois; Oliveira, Joao Paulo; Tranebjaerg, Lisbeth; Frykholm, Carina; Mane, Shrikant; Hildebrandt, Friedhelm; Srivastava, Tarak; Storm, Tina; Christensen, Erik Ilso; Nielsen, Rikke 分享 收藏
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Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome 狭缝隔膜组件KIRREL1的突变导致类固醇耐药的肾病综合征 Solanki, Ashish K.; Widmeier, Eugen; Arif, Ehtesham; Sharma, Shailza; Daga, Ankana; Srivastava, Pankaj; Kwon, Sang-Ho; Hugo, Hannah; Nakayama, Makiko; Mann, Nina; Majmundar, Amar J.; Tan, Wei; Gee, Heon Yung; Sadowski, Caroline E.; Rinat, Choni; Becker-Cohen, Rachel; Bergmann, Carsten; Rosen, Seymour; Somers, Michael; Shril, Shirlee; Huber, Tobias B.; Mane, Shrikant; Hildebrandt, Friedhelm; Nihalani, Deepak 分享 收藏
Comparing histologic evaluation of prostate tissue using nonlinear microscopy and paraffin H&E: a pilot study Cahill, Lucas C.; Fujimoto, James G.; Giacomelli, Michael G.; Yoshitake, Tadayuki; Wu, Yubo; Lin, Douglas I.; Ye, Huihui; Carrasco-Zevallos, Oscar M.; Wagner, Andrew A.; Rosen, Seymour 分享 收藏
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Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice Varga, Zoltan V.; Erdelyi, Katalin; Paloczi, Janos; Cinar, Resat; Zsengeller, Zsuzsanna K.; Jourdan, Tony; Matyas, Csaba; Nemeth, Balazs Tamas; Guillot, Adrien; Xiang, Xiaogang; Mehal, Adam; Hasko, Gyoergy; Stillman, Isaac E.; Rosen, Seymour; Gao, Bin; Kunos, George; Pacher, Pal 分享 收藏
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