Xiaolan Qian - Publications, H-index & Citations

Xiaolan Qian

soochow university - china

33H指数

143论文数

4.0K被引数

收录论文 46

发表时间

The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export

NATURE CANCER

IF28.5

2024-11-11

OAAI

Tripathi, Brajendra K.; Hirsh, Nicole H.; Qian, Xiaolan; Durkin, Marian E.; Wang, Dunrui; Papageorge, Alex G.; Lake, Ross; Evrard, Yvonne A.; Marcus, Adam I.; Ramalingam, Suresh S.; Dasso, Mary; Vousden, Karen H.; Doroshow, James H.; Walters, Kylie J.; Lowy, Douglas R.

Efficacy and cell-free DNA whole methylome based biomarker analysis of carboplatin plus taxanes neoadjuvant chemotherapy in triple negative breast cancer: A prospective multi-center cohort study 卡铂联合紫杉类药物新辅助化疗在 triple negative breast cancer 中的疗效及基于细胞自由DNA全甲基组的生物标志物分析：一项前瞻性多中心队列研究

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Chen, X.; Xiu, M.; Kang, H.; Zhang, Y.; Li, Q.; Cheng, X.; Wang, J.; Lan, B.; Chen, S.; Xiao, M.; Qian, X.; Hua, B.; Xu, B.; Zhang, P.

A pro-oncogenic RAS-GTP:RAN-GAP complex facilitates nuclear protein export and has clinical implications

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Tripathi, Brajendra K.; Hirsh, Nicole H.; Hansen, David; Qian, Xiaolan; Durkin, Marian E.; Wang, Dunrui; Papageorge, Alex G.; Lake, Ross; Evrard, Yvonne A.; Marcus, Adam; Ramalingam, Suresh S.; Dasso, Mary; Vousden, Karen; Doroshow, James H.; Walters, Kylie J.; Lowy, Douglas R.

Cytoplasmic EZH2 and the DLC1 tumor suppressor are regulated by the CRM1 nuclear export protein and by specific complex formation between mutant KRAS and RAN-GAP

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Tripathi, Brajendra; Hirsh, Nicole; Hansen, David; Qian, Xiaolan; Wang, Dunrui; Durkin, Marian E.; Lim, Ashley; Papageorge, Alex G.; Ramalingham, Suresh S.; Marcus, Adam I.; Lowy, Douglas R.

N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Qian, XL; Vass, WC; Papageorge, AG; Anborgh, PH; Lowy, DR

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells 基于转录组学的镉 (Cd) 和2,2 '，4,4'-四溴二苯醚 (BDE-47) 共同暴露的分析表明线粒体功能障碍会诱导肾小管上皮细胞中的NLRP3炎症小体和炎症细胞死亡

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

IF6.1

2022-08-01

OAAI

Zhang, Yi; Hu, Bo; Qian, Xiaolan; Xu, Guangtao; Jin, Xin; Chen, Deqing; Tang, Jie; Xu, Long

Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

NATURE COMMUNICATIONS

IF15.7

2021-12-03

OAAI

Tripathi, Brajendra K.; Anderman, Meghan F.; Bhargava, Disha; Boccuzzi, Luciarita; Qian, Xiaolan; Wang, Dunrui; Durkin, Marian E.; Papageorge, Alex G.; de Miguel, Fernando J.; Politi, Katerina; Walters, Kylie J.; Doroshow, James H.; Lowy, Douglas R.

The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

MOLECULAR CANCER

IF33.9

2021-11-02

OAAI

Sanchez-Solana, Beatriz; Wang, Dunrui; Qian, Xiaolan; Velayoudame, Parthibane; Simanshu, Dhirendra K.; Acharya, Jairaj K.; Lowy, Douglas R.

2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

IF6.1

2021-09-01

OAAI

Tang, Jie; Hu, Bo; Zheng, Huaping; Qian, Xiaolan; Zhang, Yi; Zhu, Jia; Xu, Guangtao; Chen, Deqing; Jin, Xin; Li, Wanlu; Xu, Long

MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer

FRONTIERS IN ONCOLOGY

IF3.3

2021-05-04

OAAI

Qian, Xiao-Lan; Zhou, Fang; Xu, Song; Jiang, Jian; Chen, Zhi-Peng; Wang, Shao-Kai; Zuo, Yun; Ni, Chen

Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function

CANCER RESEARCH

IF16.6

2020-09-02

OAAI

Wang, Dunrui; Qian, Xiaolan; Sanchez-Solana, Beatriz; Tripathi, Brajendra K.; Durkin, Marian E.; Lowy, Douglas R.

Epigenetic reactivation of the DLC1 tumor suppressor protein is a new approach for cancer treatment

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Tripathi, Brajendra K.; Boccuzzi, Luciarita; Anderman, Meghan; Qian, Xiaolan; Walters, Kylie J.; Doroshow, James H.; Lowy, Douglas R.

Identification of cancer-associated RhoA mutants and analogous K-Ras mutants that induce gain-of function despite low GTP binding

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Qian, Xiaolan; Papageorge, Alex; Wang, Dunrui; Tripathi, Brajendra; Gao, Yucheng; Durkin, Marian; Sanchez-Solana, Beatriz; Esposito, Dominic; Waybright, Timothy; Stephen, Andrew; Lowy, Douglas R.

A high proportion of protein phosphorylation sites identified in CPTAC breast cancer and lung adenocarcinoma may result from direct phosphorylation by CDK1

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Wang, Dunrui; Qian, Xiaolan; Eng, Sarah; Jenkins, Lisa; Durkin, Marian; Lowy, Douglas

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

JOURNAL OF CELL BIOLOGY

IF6.4

2019-07-15

OAAI

Tripathi, Brajendra K.; Anderman, Meghan F.; Qian, Xiaolan; Zhou, Ming; Wang, Dunrui; Papageorge, Alex G.; Lowy, Douglas R.

The START domain of the DLC1 tumor suppressor binds phosphatidylserine and two proteins, PLCD1 and Caveolin-1

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Sanchez-Solana, Beatriz; Wang, Dunrui; Qian, Xiaolan; Papageorge, Alex; Velayoudame, Parthibane; Acharya, Jairaj; Lowy, Douglas R.

Phosphorylation of Serine 861 in the ECT2 guanine nucleotide exchange factor activates Rho family GTPases and is a biomarker for several tumor types

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Wang, Dunrui; Qian, Xiaolan; Eng, Sarah; Nellore, Shivani; Papageorge, Alex G.; Lowy, Douglas R.

Cancer-associated point mutant in the START domain of DLC1 encodes a protein attenuated for tumor suppressor activity and for binding both Caveolin-1 and PLCD1 but not for Rho-GAP activity

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Sanchez-Solana, Beatriz; Qian, Xiaolan; Wang, Dunrui; Durkin, Marian; Tripathi, Brajendra; Papageorge, Alex; Lowy, Douglas R.

SRC inhibitors dephosphorylate and reactivate the DLC1 tumor suppressor: A new biomarker of clinical response

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Tripathi, Brajendra K.; Anderman, Meghan; Qian, Xiaolan; Zhou, Ming; Wang, Dunrui; Papageorge, Alex G.; Lowy, Douglas R.

Several cancer types are associated with increased expression and activity of the ECT2 RhoGEF and decreased expression and activity of the DLC1 RhoGAP, leading to increased RhoA activity

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Wang, Dunrui; Qian, Xiaolan; Durkin, Marian E.; Papageorge, Alexander G.; Lowy, Douglas R.

研究方向