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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors Cernak, Tim; Gesmundo, Nathan J.; Dykstra, Kevin; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; Vachal, Petr; Sperbeck, Donald; He, Shuwen; Murphy, Beth Ann; Sonatore, Lisa; Williams, Steven; Madeira, Maria; Verras, Andreas; Reiter, Maud; Lee, Claire Heechoon; Cuff, James; Sherer, Edward C.; Kuethe, Jeffrey; Goble, Stephen; Perrotto, Nicholas; Pinto, Shirly; Shen, Dong-Ming; Nargund, Ravi; Balkovec, James; DeVita, Robert J.; Dreher, Spencer D. 分享 收藏
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder Edmondson, Scott D.; Zhu, Cheng; Kar, Nam Fung; Di Salvo, Jerry; Nagabukuro, Hiroshi; Sacre-Salem, Beatrice; Dingley, Karen; Berger, Richard; Goble, Stephen D.; Morriello, Gregori; Harper, Bart; Moyes, Christopher R.; Shen, Dong-Ming; Wang, Liping; Ball, Richard; Fitzmaurice, Aileen; Frenkl, Tara; Gichuru, Loise N.; Ha, Sookhee; Hurley, Amanda L.; Jochnowitz, Nina; Levorse, Dorothy; Mistry, Shruty; Miller, Randy R.; Ormes, James; Salituro, Gino M.; Sanfiz, Anthony; Stevenson, Andra S.; Villa, Katherine; Zamlynny, Beata; Green, Stuart; Struthers, Mary; Weber, Ann E. 分享 收藏
Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors Imbriglio, Jason E.; Shen, Dong-Ming; Liang, Rui; Marby, Ken; You, Ming; Youm, Hye Won; Feng, Zhe; London, Clare; Xiong, Yusheng; Tata, Jim; Verras, Andreas; Garcia-Calvo, Margarita; Song, Xuelei; Addona, George H.; McLaren, Dave G.; He, Timothy; Murphy, Beth; Metzger, Dan E.; Salituro, Gino; Deckman, Diana; Chen, Qing; Jin, Xiaoling; Stout, Steven J.; Wang, Sheng-Ping; Wilsie, Larissa; Palyha, Oksana; Han, Seongah; Hubbard, Brian K.; Previs, Stephen F.; Pinto, Shiny; Taggart, Andrew 分享 收藏
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety He, Shuwen; Hong, Qingmei; Lai, Zhong; Yang, David X.; Ting, Pauline C.; Kuethe, Jeffrey T.; Cernak, Timothy A.; Dykstra, Kevin D.; Sperbeck, Donald M.; Wu, Zhicai; Yu, Yang; Yang, Ginger X.; Jian, Tianying; Liu, Jian; Guiadeen, Deodial; Krikorian, Arto D.; Sonatore, Lisa M.; Wiltsie, Judyann; Liu, Jinqi; Gorski, Judith N.; Chung, Christine C.; Gibson, Jack T.; Lisnock, JeanMarie; Xiao, Jianying; Wolff, Michael; Tong, Sharon X.; Madeira, Maria; Karanam, Bindhu V.; Shen, Dong-Ming; Balkovec, James M.; Pinto, Shirly; Nargund, Ravi P.; DeVita, Robert J. 分享 收藏
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder Moyes, Christopher R.; Berger, Richard; Goble, Stephen D.; Harper, Bart; Shen, Dong-Ming; Wang, Liping; Bansal, Alka; Brown, Patricia N.; Chen, Airu S.; Dingley, Karen H.; Di Salvo, Jerry; Fitzmaurice, Aileen; Gichuru, Loise N.; Hurley, Amanda L.; Jochnowitz, Nina; Miller, Randall R.; Mistry, Shruty; Nagabukuro, Hiroshi; Salituro, Gino M.; Sanfiz, Anthony; Stevenson, Andra S.; Villa, Katherine; Zamlynny, Beata; Struthers, Mary; Weber, Ann E.; Edmondson, Scott D. 分享 收藏
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety He, Shuwen; Hong, Qingmei; Lai, Zhong; Wu, Zhicai; Yu, Yang; Kim, David W.; Ting, Pauline C.; Kuethe, Jeffrey T.; Yang, Ginger X.; Jian, Tianying; Liu, Jian; Guiadeen, Deodial; Krikorian, Arto D.; Sperbeck, Donald M.; Sonatore, Lisa M.; Wiltsie, Judyann; Chung, Christine C.; Gibson, Jack T.; Lisnock, JeanMarie; Murphy, Beth A.; Gorski, Judith N.; Liu, Jinqi; Chen, Dunlu; Chen, Xiaoli; Wolff, Michael; Tong, Sharon X.; Madeira, Maria; Karanam, Bindhu V.; Shen, Dong-Ming; Balkovec, James M.; Pinto, Shiny; Nargund, Ravi P.; DeVita, Robert J. 分享 收藏
Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation Ponte, Cristiano G.; McManus, Owen B.; Schmalhofer, William A.; Shen, Dong-Ming; Dai, Ge; Stevenson, Andra; Sur, Sylvie; Shah, Tarak; Kiss, Laszlo; Shu, Min; Doherty, James B.; Nargund, Ravi; Kaczorowski, Gregory J.; Suarez-Kurtz, Guilherme; Garcia, Maria L. 分享 收藏
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Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase Zhao, Xuemei; Southwick, Katie; Cardasis, Helene L.; Du, Yi; Lassman, Michael E.; Xie, Dan; El-Sherbeini, Mohamed; Geissler, Wayne M.; Pryor, KellyAnn D.; Verras, Andreas; Garcia-Calvo, Margarita; Shen, Dong-Ming; Yates, Nathan A.; Pinto, Shirly; Hendrickon, Ronald C. 分享 收藏
Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice Kaczmarek, P.; Singh, V.; Cashen, D. E.; Yang, L.; Berk, S.; Pasternak, A.; Xiong, Y.; Shen, D. -M.; Hutchins, S. M.; Chapman, K.; Wiedenmann, B.; Schaeffer, J. M.; Strowski, M. Z. 分享 收藏
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity Lynch, CL; Hale, JJ; Budhu, RJ; Gentry, AL; Finke, PE; Caldwell, CG; Mills, SG; MacCoss, M; Shen, DM; Chapman, KT; Malkowitz, L; Springer, MS; Gould, SL; DeMartino, JA; Siciliano, SJ; Cascieri, MA; Carella, A; Carver, G; Karen, H; Schleif, WA; Danzeisen, R; Hazuda, D; Kessler, J; Lineberger, J; Miller, M; Emini, E 分享 收藏
Mass spectrometry screening of combinatorial mixtures, correlation of measured and predicted electrospray ionization spectra Yates, N; Wislocki, D; Roberts, A; Berk, S; Klatt, T; Shen, DM; Willoughby, C; Rosauer, K; Chapman, K; Griffin, P 分享 收藏
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