未登录Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules
Gollner, Andreas; Rudolph, Dorothea; Weyer-Czernilofsky, Ulrike; Baumgartinger, Rosa; Jung, Peter; Weinstabl, Harald; Ramharter, Jurgen; Grempler, Rolf; Quant, Jens; Rinnenthal, Jorg; Pitarch, Alejandro Perez; Golubovic, Bojana; Gerlach, Daniel; Bader, Gerd; Wetzel, Kristiane; Otto, Sebastian; Mandl, Christian; Boehmelt, Guido; Mcconnell, Darryl B.; Kraut, Norbert; Sini, Patrizia .png)
分享.png)
收藏BI 907828: A highly potent MDM2-p53 antagonist suitable for intermittent dose schedulesGollner, Andreas; Sini, Patrizia; Rudolph, Dorothea; Weinstabl, Harald; Ramharter, Juergen; Weyer-Czernilofsky, Ulrike; Golubovic, Bojana; Grempler, Rolf; Pitarch, Alejandro Perez; Sailer, Reinhard; McConnell, Darryl B.; Kraut, Norbert 分享 收藏 BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse modelsHao, Xiaoguang; Bahia, Ravinder K.; Cseh, Orsolya; Bozek, Danielle A.; Blake, Sophia; Rinnenthal, Joerg; Weyer-Czernilofsky, Ulrike; Rudolph, Dorothea; Luchman, H. Artee 分享 收藏 Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase DysfunctionRieunier, Guillaume; Wu, Xiaoning; Harris, Letitia E.; Mills, Jack, V; Nandakumar, Ashwin; Colling, Laura; Seraia, Elena; Hatch, Stephanie B.; Ebner, Daniel, V; Folkes, Lisa K.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Ryan, Anderson J.; Macaulay, Valentine M. 分享 收藏 分享 收藏 A promising blood-brainbarrier penetrant MDM2-p53 antagonist, BI-MDM2, increases survival in orthotopic, glioblastoma patient-derived xenograft modelsTuma, Ann C. Mladek; Gupta, Shiv; Talele, Surabhi; Mohammad, Afroz Shareef; Bakken, Katrina K.; He, Helen; Hu, Zeng; Connors, Margaret A.; Burgenske, Danielle M.; Carlson, Brett L.; Elmquist, William F.; Weyer-Czernilofsky, Ulrike; Sarkaria, Jann N. 分享 收藏 Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer ModelsIGF-1/IGF-2-Neutralizing抗体Xentuzumab (BI 836845) 联合恩扎鲁他胺在前列腺癌模型中的抗肿瘤活性Weyer-Czernilofsky, Ulrike; Hofmann, Marco H.; Friedbichler, Katrin; Baumgartinger, Rosa; Adam, Paul J.; Solca, Flavio; Kraut, Norbert; Nguyen, Holly M.; Corey, Eva; Liu, Gang; Sprenger, Cynthia C.; Plymate, Stephen R.; Bogenrieder, Thomas 分享 收藏 Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor StageAleksic, Tamara; Gray, Nicki; Wu, Xiaoning; Rieunier, Guillaume; Osher, Eliot; Mills, Jack; Verrill, Clare; Bryant, Richard J.; Han, Cheng; Hutchinson, Kathryn; Lambert, Adam G.; Kumar, Rajeev; Hamdy, Freddie C.; Weyer-Czernilofsky, Ulrike; Sanderson, Michael P.; Bogenrieder, Thomas; Taylor, Stephen; Macaulay, Valentine M. 分享 收藏 BI 907828: A novel, potent MDM2 inhibitor that induces antitumor immunologic memory and acts synergistically with an anti-PD-1 antibody in syngeneic mouse models of cancerRudolph, Dorothea; Reschke, Markus; Blake, Sophia; Rinnenthal, Joerg; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Gollner, Andreas; Haslinger, Christian; Garin-Chesa, Pilar; Quant, Jens; McConnell, Darryl B.; Norbert, Kraut; Moll, Juergen 分享 收藏 A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedulesRudolph, Dorothea; Gollner, Andreas; Blake, Sophia; Rinnenthal, Joerg; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Haslinger, Christian; Garin-Chesa, Pilar; Quant, Jens; McConnell, Darryl B.; Moll, Juergen; Norbert, Kraut 分享 收藏 BI 907828: A highly potent MDM2 inhibitor with low human dose estimation, designed for high-dose intermittent schedules in the clinicRinnenthal, Joerg; Rudolph, Dorothea; Blake, Sophia; Gollner, Andreas; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Haslinger, Christian; Garin-Chesa, Pilar; Moll, Juergen; Kraut, Norbert; McConnell, Darryl; Quant, Jens 分享 收藏 Combination of the CDK4/6 inhibitor abemaciclib with xentuzumab, a humanized IGF-1 and IGF-2 ligand co-neutralizing monoclonal antibody, results in synergistic antineoplastic effects in human breast cancer cell linesWeyer-Czernilofsky, Ulrike; Baumgartinger, Rosa; Schmittner, Susanne; Gong, Xueqian; Buchanan, Sean; Beckmann, Richard P.; Marugan, Carlos; Torres, Raquel; Boehnke, Karsten; Lallena, Maria Jose; Solca, Flavio; Kraut, Norbert; Bogenrieder, Thomas 分享 收藏 Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotypeHirt, Ulrich A.; Waizenegger, Irene C.; Schweifer, Norbert; Haslinger, Christian; Gerlach, Daniel; Braunger, Juergen; Weyer-Czernilofsky, Ulrike; Stadtmueller, Heinz; Sapountzis, Ioannis; Bader, Gerd; Zoephel, Andreas; Bister, Bojan; Baum, Anke; Quant, Jens; Kraut, Norbert; Garin-Chesa, Pilar; Adolf, Guenther R. 分享 收藏 Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancerIreland, Lucy; Santos, Almudena; Campbell, Fiona; Figueiredo, Carlos; Hammond, Dean; Ellies, Lesley G.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Schmid, Michael; Mielgo, Ainhoa 分享 收藏 The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF TherapySanderson, Michael P.; Hofmann, Marco H.; Garin-Chesa, Pilar; Schweifer, Norbert; Wernitznig, Andreas; Fischer, Stefan; Jeschko, Astrid; Meyer, Reiner; Moll, Juergen; Pecina, Thomas; Arnhof, Heribert; Weyer-Czernilofsky, Ulrike; Zahn, Stephan K.; Adolf, Unther R.; Kraut, Norbert 分享 收藏 分享 收藏 分享 收藏 Xentuzumab, a humanized IGF1 and IGF-2 ligand neutralizing antibody, improves the antitumor efficacy of enzalutamide in preclinical models of prostate cancerWeyer-Czernilofsky, Ulrike; Hofmann, Marco H.; Adam, Paul J.; Solca, Flavio; Friedbichler, Katrin; Kraut, Norbert; Corey, Eva; Bogenrieder, Thomas 分享 收藏 Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth FactorsIreland, Lucy; Santos, Almudena; Ahmed, Muhammad S.; Rainer, Carolyn; Nielsen, Sebastian R.; Quaranta, Valeria; Weyer-Czernilofsky, Ulrike; Engle, Danielle D.; Perez-Mancera, Pedro A.; Coupland, Sarah E.; Taktak, Azzam; Bogenrieder, Thomas; Tuveson, David A.; Campbell, Fiona; Schmid, Michael C.; Mielgo, Ainhoa 分享 收藏 Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 InteractionGollner, Andreas; Rudolph, Dorothea; Arnhof, Heribert; Bauer, Markus; Blake, Sophia M.; Boehmelt, Guido; Cockroft, Xiao-Ling; Dahmann, Georg; Ettmayer, Peter; Gerstberger, Thomas; Karolyi-Oezguer, Jale; Kessler, Dirk; Kofink, Christiane; Ramharter, Juergen; Rinnenthal, Joerg; Savchenko, Alexander; Schnitzer, Renate; Weinstabl, Harald; Weyer-Czernilofsky, Ulrike; Wunberg, Tobias; McConnell, Darryl B. 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
