未登录 分享 收藏
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study Lasater, Elisabeth A.; Amin, Dhara N.; Bannerji, Rajat; Mali, Raghuveer Singh; Barrett, Kathy; Rys, Ryan N.; Oeh, Jason; Lin, Eva; Sterne-Weiler, Tim; Ingalla, Ellen Rei; Go, MaryAnn; Yu, Shang-Fan; Krem, Maxwell M.; Arthur, Chris; Hahn, Uwe; Johnston, Anna; Karur, Vinit; Khan, Nadia; Marlton, Paula; Phillips, Tycel; Gritti, Giuseppe; Seymour, John F.; Tani, Monica; Yuen, Sam; Martin, Scott; Chang, Matthew T.; Rose, Christopher M.; Pham, Victoria C.; Polson, Andrew G.; Chang, YiMeng; Wever, Claudia; Johnson, Nathalie A.; Jiang, Yanwen; Hirata, Jamie; Sampath, Deepak; Musick, Lisa; Flowers, Christopher R.; Wertz, Ingrid E. 分享 收藏
Development of T-cell engagers selective for cells co-expressing two antigens Dicara, Danielle M.; Bhakta, Sunil; Go, Mary Ann; Ziai, James; Firestein, Ron; Forrest, Bill; Gu, Chen; Leong, Steven R.; Lee, Genee; Yu, Shang-Fan; Polson, Andrew G.; Agard, Nicholas J. 分享 收藏
Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia Lenk, Lennart; Winterberg, Dorothee; Vogiatzi, Fotini; Laqua, Anna; Spory, Lea; Mayar, Ahmad; Dietterle, Anna; Muench, Gina; Vokuhl, Christian; Richter, Julia; Polson, Andrew G.; Schueler, Thomas; Kahlert, Ulf D.; Peipp, Matthias; Valerius, Thomas; Schrappe, Martin; Cario, Gunnar; Jumaa, Hassan; Hobeika, Elias; Brueggemann, Monika; Alsadeq, Ameera; Schewe, Denis M. 分享 收藏
Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer Wang, Peiyin; Sun, Liping L.; Clark, Robyn; Hristopoulos, Maria; Chiu, Cecilia P. C.; Dillon, Michael; Lin, WeiYu; Lo, Amy A.; Chalsani, Sreedevi; Das Thakur, Meghna; Savill, Kristin M. Zimmerman; Rouge, Lionel; Lupardus, Patrick; Piskol, Robert; Husain, Bushra; Ellerman, Diego; Shivva, Vittal; Leong, Steven R.; Ovacik, Meric; Totpal, Klara; Wu, Yan; Spiess, Christoph; Lee, Genee; Leipold, Douglas D.; Polson, Andrew G. 分享 收藏
A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma Kakiuchi-Kiyota, Satoko; Ross, Thorsten; Wallweber, Heidi Ackerly; Kiefer, James R.; Schutten, Melissa M.; Adedeji, Adeyemi O.; Cai, Hao; Hendricks, Robert; Cohen, Sivan; Myneni, Srividya; Liu, Luna; Fullerton, Aaron; Corr, Nicholas; Yu, Lanlan; Nagata, Denise de Almeida; Zhong, Shelly; Leong, Steven R.; Li, Ji; Nakamura, Rin; Sumiyoshi, Teiko; Li, Jinze; Ovacik, Ayse Meric; Zheng, Bing; Dillon, Mike; Spiess, Christoph; Wingert, Susanne; Rajkovic, Erich; Ellwanger, Kristina; Reusch, Uwe; Polson, Andrew G. 分享 收藏
A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides Zacharias, Neelie; Podust, Vladimir N.; Kajihara, Kimberly K.; Leipold, Douglas; Del Rosario, Geoffrey; Thayer, Desiree; Dong, Emily; Paluch, Maciej; Fischer, David; Zheng, Kai; Lei, Corinna; He, Jintang; Ng, Carl; Su, Dian; Liu, Luna; Masih, Shabkhaiz; Sawyer, William; Tinianow, Jeff; Marik, Jan; Yip, Victor; Li, Guangmin; Chuh, Josefa; Morisaki, J. Hiroshi; Park, Summer; Zheng, Bing; Hernandez-Barry, Hilda; Loyet, Kelly M.; Xu, Min; Kozak, Katherine R.; Phillips, Gail Lewis; Shen, Ben-Quan; Wu, Cong; Xu, Keyang; Yu, Shang-Fan; Kamath, Amrita; Rowntree, Rebecca K.; Reilly, Dorothea; Pillow, Thomas; Polson, Andrew; Schellenberger, Volker; Hazenbos, Wouter L. W.; Sadowsky, Jack 分享 收藏
Calicheamicin Antibody-Drug Conjugates with Improved Properties Vollmar, Breanna S.; Frantz, Chris; Schutten, Melissa M.; Zhong, Fiona; Rosario, Geoffrey del; Go, Mary Ann T.; Yu, Shang-Fan; Leipold, Douglas D.; Kamath, Amrita, V; Ng, Carl; Xu, Keyang; Cruz-Chuh, Josefa Dela; Kozak, Katherine R.; Chen, Jinhua; Xu, Zijin; Wai, John; Adhikari, Pragya; Erickson, Hans K.; Dragovich, Peter S.; Polson, Andrew G.; Pillow, Thomas H. 分享 收藏
An Anti-CD22-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models Yu, Shang-Fan; Lee, Donna W.; Zheng, Bing; Del Rosario, Geoffrey; Leipold, Douglas; Booler, Helen; Zhong, Fiona; Carrasco-Triguero, Montserrat; Hong, Kyu; Yan, Peter; Rowntree, Rebecca K.; Schutten, Melissa M.; Pillow, Thomas; Sadowsky, Jack D.; Dragovich, Peter S.; Polson, Andrew G. 分享 收藏
Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response Dela Cruz Chuh, Josefa; Go, MaryAnn; Chen, Yvonne; Guo, Jun; Rafidi, Hanine; Mandikian, Danielle; Sun, Yonglian; Lin, Zhonghua; Schneider, Kellen; Zhang, Pamela; Vij, Rajesh; Sharpnack, Danielle; Chan, Pamela; de la Cruz, Cecile; Sadowsky, Jack; Seshasayee, Dhaya; Koerber, James T.; Pillow, Thomas H.; Phillips, Gail D.; Rowntree, Rebecca K.; Boswell, C. Andrew; Kozak, Katherine R.; Polson, Andrew G.; Polakis, Paul; Yu, Shang-Fan; Dragovich, Peter S.; Agard, Nicholas J. 分享 收藏
Preclinical pharmacology and safety of RO7297089, a novel anti-BCMA/CD16a bispecific antibody for the treatment of multiple myeloma Kakiuchi-Kiyota, Satoko; Schutten, Melissa M.; Adedeji, Adeyemi O.; Cai, Hao; Hendricks, Robert; Liu, Luna; Cohen, Sivan; Fullerton, Aaron M.; Corr, Nicholas; Yu, Lanlan; Nagata, Denise de Almeida; Zhong, Shelly; Dillon, Michael; Spiess, Christoph; Leong, Steve R.; Zheng, Bing; Wingert, Susanne; Reusch, Uwe; Knackmuss, Stefan; Ross, Thorsten; Polson, Andrew; Ovacik, Ayse M. 分享 收藏
Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin Li, Dongwei; Lee, Donna; Dere, Randall C.; Zheng, Bing; Yu, Shang-Fan; Fuh, Franklin K.; Kozak, Katherine R.; Chung, Shan; Yadav, Daniela Bumbaca; Nazzal, Denise; Danilenko, Dimitry; Go, Mary Ann T.; Williams, Marna; Polson, Andrew G.; Poon, Kirsten Achilles; Prabhu, Saileta 分享 收藏
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo Su, Dian; Chen, Jinhua; Cosino, Ely; dela Cruz-Chuh, Josefa; Davis, Helen; Del Rosario, Geoffrey; Figueroa, Isabel; Goon, Leanne; He, Jintang; Kamath, Amrita V.; Kaur, Surinder; Kozak, Katherine R.; Lau, Jeffrey; Lee, Donna; Lee, M. Violet; Leipold, Douglas; Liu, Luna; Liu, Peter; Lu, Guo-Liang; Nelson, Chris; Ng, Carl; Pillow, Thomas H.; Polakis, Paul; Polson, Andrew G.; Rowntree, Rebecca K.; Saad, Ola; Safina, Brian; Stagg, Nicola J.; Tercel, Moana; Vandlen, Richard; Vollmar, Breanna S.; Wai, John; Wang, Tao; Wei, BinQing; Xu, Keyang; Xue, Juanjuan; Xu, Zijin; Yan, Gang; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zhong, Fiona; Dragovich, Peter S. 分享 收藏
Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma Stewart, A. Keith; Krishnan, Amrita Y.; Singhal, Seema; Boccia, Ralph V.; Patel, Manish R.; Niesvizky, Ruben; Chanan-Khan, Asher A.; Ailawadhi, Sikander; Brumm, Jochen; Mundt, Kirsten E.; Hong, Kyu; McBride, Jacqueline; Quyen Shon-Nguyen; Xiao, Yuanyuan; Ramakrishnan, Vanitha; Polson, Andrew G.; Samineni, Divya; Leipold, Douglas; Humke, Eric W.; McClellan, James Scott; Berdeja, Jesus G. 分享 收藏
Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia Leipold, Douglas D.; Figueroa, Isabel; Masih, Shabkhaiz; Latifi, Brandon; Yip, Victor; Shen, Ben-Quan; Dere, Randall C.; Carrasco-Triguero, Montserrat; Lee, M. Violet; Saad, Ola M.; Liu, Luna; He, Jintang; Su, Dian; Xu, Keyang; Vuillemenot, Brian R.; Laing, Steven T.; Schutten, Melissa; Kozak, Katherine R.; Zheng, Bing; Polson, Andrew G.; Kamath, Amrita V. 分享 收藏
Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC Figueroa, Isabel; Leipold, Doug; Leong, Steve; Zheng, Bing; Triguero-Carrasco, Montserrat; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Xu, Keyang; Schutten, Melissa; Wang, Hong; Polson, Andrew G.; Kamath, Amrita V. 分享 收藏
Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates Zhang, Donglu; Yu, Shang-Fan; Khojasteh, S. Cyrus; Ma, Yong; Pillow, Thomas H.; Sadowsky, Jack D.; Su, Dian; Kozak, Katherine R.; Xu, Keyang; Polson, Andrew G.; Dragovich, Peter S.; Hop, Cornelis E. C. A. 分享 收藏
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates Caculitan, Nina G.; Chuh, Josefa dela Cruz; Ma, Yong; Zhang, Donglu; Kozak, Katherine R.; Liu, Yichin; Pillow, Thomas H.; Sadowsky, Jack; Cheung, Tommy K.; Phung, Qui; Haley, Benjamin; Lee, Byoung-Chul; Akita, Robert W.; Sliwkowski, Mark X.; Polson, Andrew G. 分享 收藏
Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors 稳定微管溶素抗体-药物缀合物以实现抗多药耐药肿瘤的活性 Staben, Leanna R.; Yu, Shang-Fan; Chen, Jinhua; Yan, Gang; Xu, Zijin; Del Rosario, Geoffrey; Lau, Jeffrey T.; Liu, Luna; Guo, Jun; Zheng, Bing; dela Cruz-Chuh, Josefa; Lee, Byoung-Chul; Ohri, Rachana; Cai, Wenwen; Zhou, Hongxiang; Kozak, Katherine R.; Xu, Keyang; Phillips, Gail D. Lewis; Lu, Jiawei; Wai, John; Polson, Andrew G.; Pillow, Thomas H. 分享 收藏
T cell-dependent bispecific antibody anti-CD79b/CD3 as a potential therapy for B-cell malignancies Wang, Peiyin; Hristopoulos, Maria; Clark, Robyn; Chen, Yvonne; Ellerman, Diego; Mathieu, Mary; Spiess, Christoph; Li, Jessica; Chalouni, Cecile; Sukumaran, Siddharth; Stefanich, Eric; Wallin, Jeffrey; Li, Robert; Zabka, Tanja; Totpal, Klara; Dennis, Mark; Ebens, Allen; Gould, Stephen; Polson, Andrew; Sun, Liping Laura 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
