未登录 Safety and efficacy of vebicorvir administered with entecavir in treatment-naive patients with chronic hepatitis B virus infection Sulkowski, Mark S.; Agarwal, Kosh; Ma, Xiaoli; Nguyen, Tuan T.; Schiff, Eugene R.; Hann, Hie-Won L.; Dieterich, Douglas T.; Nahass, Ronald G.; Park, James S.; Chan, Sing; Han, Steven-Huy B.; Gane, Edward J.; Bennett, Michael; Alves, Katia; Evanchik, Marc; Yan, Ran; Huang, Qi; Lopatin, Uri; Colonno, Richard; Ma, Julie; Knox, Steven J.; Stamm, Luisa M.; Bonacini, Maurizio; Jacobson, Ira M.; Ayoub, Walid S.; Weilert, Frank; Ravendhran, Natarajan; Ramji, Alnoor; Kwo, Paul Yien; Elkhashab, Magdy; Hassanein, Tarek; Bae, Ho S.; Lalezari, Jacob P.; Fung, Scott K.; Yuen, Man-Fung 分享 收藏
Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infection Yuen, Man-Fung; Agarwal, Kosh; Ma, Xiaoli; Nguyen, Tuan T.; Schiff, Eugene R.; Hann, Hie-Won L.; Dieterich, Douglas T.; Nahass, Ronald G.; Park, James S.; Chan, Sing; Han, Steven-Huy B.; Gane, Edward J.; Bennett, Michael; Alves, Katia; Evanchik, Marc; Yan, Ran; Huang, Qi; Lopatin, Uri; Colonno, Richard; Ma, Julie; Knox, Steven J.; Stamm, Luisa M.; Bonacini, Maurizio; Jacobson, Ira M.; Ayoub, Walid S.; Weilert, Frank; Ravendhran, Natarajan; Ramji, Alnoor; Kwo, Paul Yien; Elkhashab, Magdy; Hassanein, Tarek; Bae, Ho S.; Lalezari, Jacob P.; Fung, Scott K.; Sulkowski, Mark S. 分享 收藏
Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients Huang, Qi; Zhou, Bin; Cai, Dawei; Zong, Yuhua; Wu, Yaobo; Liu, Shi; Mercier, Alexandre; Guo, Haitao; Hou, Jinlin; Colonno, Richard; Sun, Jian 分享 收藏
Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731 Huang, Qi; Cai, Dawei; Yan, Ran; Li, Lichun; Zong, Yuhua; Guo, Lida; Mercier, Alexandre; Zhou, Yi; Tang, Ariel; Henne, Kirk; Colonno, Richard 分享 收藏
Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial Yuen, Man-Fung; Agarwal, Kosh; Gane, Edward J.; Schwabe, Christian; Ahn, Sang Hoon; Kim, Dong Joon; Lim, Young-Suk; Cheng, Wendy; Sievert, William; Visvanathan, Kumar; Ruby, Eric; Liaw, Sandy; Yan, Ran; Huang, Qi; Colonno, Richard; Lopatin, Uri 分享 收藏
Interim safety and efficacy results of the ABI-H0731 phase 2a program exploring the combination of ABI-H0731 with Nuc therapy in treatment-naive and treatment-suppressed chronic hepatitis B patients Ma, Xiaoli; Lalezari, Jacob; Tuan Nguyen; Bae, Ho; Schiff, Eugene R.; Fung, Scott; Yuen, Man-Fung; Hassanein, Tarek; Hann, Hie-Won; Elkhashab, Magdy; Dieterich, Douglas; Sulkowski, Mark; Kwo, Paul; Nahass, Ronald; Agarwal, Kosh; Ramji, Alnoor; Park, James; Ravendhran, Natarajan; Chan, Sing; Weilert, Frank; Han, Steven-Huy; Ayoub, Walid; Gane, Edward; Jacobson, Ira; Bennett, Michael; Huang, Qi; Yan, Ran; Huey, Vivian; Ruby, Eric; Liaw, Sandy; Colonno, Richard; Lopatin, Uri 分享 收藏
Phase 1a Study of the Safety, Tolerability and Pharmacokinetics of ABI-H2158, a Novel Second-Generation HBV Core Inhibitor, in Healthy Volunteers Gane, Edward; Schwabe, Christian; Evanhcik, Marc; Ruby, Eric; Liaw, Sandy; Alves, Katia; Colonno, Richard; Lopatin, Uri 分享 收藏
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir 人类免疫缺陷病毒1型 (HIV-1) 附着抑制剂Temsavir及其膦酰氧基甲基前药Fostemsavir的发现 Wang, Tao; Ueda, Yasu; Zhang, Zhongxing; Yin, Zhiwei; Matiskella, John; Pearce, Bradley C.; Yang, Zheng; Zheng, Ming; Parker, Dawn D.; Yamanaka, Gregory A.; Gong, Yi-Fei; Ho, Hsu-Tso; Colonno, Richard J.; Langley, David R.; Lin, Pin-Fang; Meanwell, Nicholas A.; Kadow, John F. 分享 收藏
Interim safety, tolerability pharmacokinetics, and antiviral activity of ABI-H0731, a novel core protein allosteric modulator, in healthy volunteers and non-cirrhotic viremic subjects with chronic hepatitis B Yuen, M. -F.; Agarwal, K.; Gane, E.; Schwabe, C.; Cheng, W.; Sievert, W.; Kim, D. J.; Ahn, S. H.; Lim, Y. -S.; Visvanathan, K.; Ruby, E.; Liaw, S.; Colonno, R.; Lopatin, U. 分享 收藏
Effectiveness of ravidasvir plus sofosbuvir in interferon-naive and treated patients with chronic hepatitis C genotype-4 Esmat, Gamal; Elbaz, Tamer; El Raziky, Maissa; Gomaa, Asmaa; Abouelkhair, Mahmoud; El Deen, Hadeel Gamal; Sabry, Aliaa; Ashour, Mohamed; Allam, Naglaa; Abdel-Hamid, Mohamed; Nada, Ola; Helmy, Sherine; Abdel-Maguid, Hanaa; Colonno, Richard; Brown, Nathaniel; Ruby, Eric; Vig, Pamela; Waked, Imam 分享 收藏
Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound Wang, Jie; Shen, Tao; Huang, Xiangbo; Kumar, G. Renuka; Chen, Xiangmei; Zeng, Zhenzhen; Zhang, Ruiyang; Chen, Ran; Li, Tong; Zhang, Tianying; Yuan, Quan; Li, Pao-Chen; Huang, Qi; Colonno, Richard; Jia, Jidong; Hou, Jinlin; McCrae, Malcolm A.; Gao, Zhiliang; Ren, Hong; Xia, Ningshao; Zhuang, Hui; Lu, Fengmin 分享 收藏
FINAL RESULTS OF THE PYRAMID 1 STUDY, A PHASE 3 REGISTRATIONAL TRIAL OF RAVIDASVIR (PPI-668) AND SOFOSBUVIR IN HCV GENOTYPE-4 PATIENTS: HIGH RATES OF SUSTAINED VIRAL CLEARANCE IN CIRRHOTIC AND NON-CIRRHOTIC PATIENTS Esmat, G.; El Raziky, M.; Gomaa, A.; Elbaz, T.; Abouelkhair, M.; Sabry, A.; Deen, H. Gamel E.; Ashour, M.; Abdel-Hamid, M.; Nada, O.; Helmy, S.; Abdel-Maguid, H.; Colonno, R.; Brown, N.; Ruby, E.; Vig, P.; Waked, I. 分享 收藏
Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase Lemm, Julie A.; Liu, Mengping; Gentles, Robert G.; Ding, Min; Voss, Stacey; Pelosi, Lenore A.; Wang, Ying-Kai; Rigat, Karen L.; Mosure, Kathleen W.; Bender, John A.; Knipe, Jay O.; Colonno, Richard; Meanwell, Nicholas A.; Kadow, John F.; Santone, Kenneth S.; Roberts, Susan B.; Gao, Min 分享 收藏
HIGH RATE OF SUSTAINED VIROLOGIC RESPONSE IN PATIENTS WITH HCV GENOTYPE-1A INFECTION: A PHASE 2 TRIAL OF FALDAPREVIR, DELEOBUVIR AND PPI-668, WITH AND WITHOUT RIBAVIRIN Lalezari, J.; Holland, L.; Glutzer, E.; Vig, P.; Elgadi, M.; Stern, J. O.; Colonno, R.; Halfon, S.; Ruby, E.; Huang, N.; Nash, E.; Brown, N. 分享 收藏
The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona 分享 收藏
Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection Scola, Paul M.; Wang, Alan Xiangdong; Good, Andrew C.; Sun, Li-Qiang; Combrink, Keith D.; Campbell, Jeffrey A.; Chen, Jie; Tu, Yong; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley; Zheng, Barbara; Hewawasam, Piyasena; Ding, Min; Thuring, Jan; Li, Jianqing; Hernandez, Dennis; Yu, Fei; Falk, Paul; Zhai, Guangzhi; Sheaffer, Amy K.; Chen, Chaoqun; Lee, Min S.; Barry, Diana; Knipe, Jay O.; Li, Wenying; Han, Yong-Hae; Jenkins, Susan; Gesenberg, Christoph; Gao, Qi; Sinz, Michael W.; Santone, Kenneth S.; Zvyaga, Tatyana; Rajamani, Ramkumar; Klei, Herbert E.; Colonno, Richard J.; Grasela, Dennis M.; Hughes, Eric; Chien, Caly; Adams, Stephen; Levesque, Paul C.; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona 分享 收藏
Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir Belema, Makonen; Nguyen, Van N.; Bachand, Carol; Deon, Dan H.; Goodrich, Jason T.; James, Clint A.; Lavoie, Rico; Lopez, Omar D.; Martel, Alain; Romine, Jeffrey L.; Ruediger, Edward H.; Snyder, Lawrence B.; St Laurent, Denis R.; Yang, Fukang; Zhu, Juliang; Wong, Henry S.; Langley, David R.; Adams, Stephen P.; Cantor, Glenn H.; Chimalakonda, Anjaneya; Fura, Aberra; Johnson, Benjamin M.; Knipe, Jay O.; Parker, Dawn D.; Santone, Kenneth S.; Fridell, Robert A.; Lemm, Julie A.; O'Boyle, Donald R., II; Colonno, Richard J.; Gao, Min; Meanwell, Nicholas A.; Hamann, Lawrence G. 分享 收藏
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase Gentles, Robert G.; Ding, Min; Bender, John A.; Bergstrom, Carl P.; Grant-Young, Katharine; Hewawasam, Piyasena; Hudyma, Thomas; Martin, Scott; Nickel, Andrew; Regueiro-Ren, Alicia; Tu, Yong; Yang, Zhong; Yeung, Kap-Sun; Zheng, Xiaofan; Chao, Sam; Sun, Jung-Hui; Beno, Brett R.; Camac, Daniel M.; Chang, Chong-Hwan; Gao, Mian; Morin, Paul E.; Sheriff, Steven; Tredup, Jeff; Wan, John; Witmer, Mark R.; Xie, Dianlin; Hanumegowda, Umesh; Knipe, Jay; Mosure, Kathy; Santone, Kenneth S.; Parker, Dawn D.; Zhuo, Xiaoliang; Lemm, Julie; Liu, Mengping; Pelosi, Lenore; Rigat, Karen; Voss, Stacey; Wang, Yi; Wang, Ying-Kai; Colonno, Richard J.; Gao, Min; Roberts, Susan B.; Gao, Qi; Ng, Alicia; Meanwell, Nicholas A.; Kadow, John F. 分享 收藏
VAST MAJORITY OF DETECTED NS5A RESISTANT VARIANTS ARE NOT AMPLIFIED IN HCV PATIENTS DURING 3-DAY MONOTHERAPY WITH THE OPTIMIZED NS5A INHIBITOR PPI-668 Huang, Q.; Huang, N.; Huq, A.; Lau, M.; Peng, E.; Lalezari, J.; Farrell, G.; Shah, P.; Lawitz, E.; Vig, P.; Brown, N.; Colonno, R. 分享 收藏
Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure-Activity Relationships Associated with 4-Fluoro-6-azaindole Derivatives Leading to the Identification of 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248) Regueiro-Ren, Alicia; Xue, Qiufen M.; Swidorski, Jacob J.; Gong, Yi-Fei; Mathew, Marina; Parker, Dawn D.; Yang, Zheng; Eggers, Betsy; D'Arienzo, Celia; Sun, Yongnian; Malinowski, Jacek; Gao, Qi; Wu, Dedong; Langley, David R.; Colonno, Richard J.; Chien, Caly; Grasela, Dennis M.; Zheng, Ming; Lin, Pin-Fang; Meanwell, Nicholas A.; Kadow, John F. 分享 收藏
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