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The glutaminase inhibitor CB-839 synergizes with CDK4/6 and PARP inhibitors in pre-clinical tumor models Emberley, Ethan D.; Bennett, Mark; Chen, Jason; Gross, Matthew; Huang, Tony; Makkouk, Amani; Marguier, Gisele; Pan, Alison; Spurlock, Sandra M.; Steggerda, Susanne; Parlati, Francesco 分享 收藏
Responsiveness of controlled attenuation parameter (CAP) and its correlation with magnetic resonance imaging-proton density fat fraction (MRI-PDFF) in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH) Noureddin, M.; Kayali, Z.; Harrison, S.; Ruane, P.; Gitlin, N.; Lawitz, E.; Bennett, M.; Vuppalanchi, R.; Freilich, B.; Harting, E.; Mccolgan, B.; Myers, R.; Middleton, M.; Sirlin, C.; Charlton, M.; Lai, M.; Mantry, P.; Loomba, R. 分享 收藏
Phase 1 study of CB-839, a small molecule inhibitor of glutaminase, in combination with everolimus in patients (pts) with clear cell and papillary renal cell cancer (RCC) Meric-Bernstam, F.; Tannir, N.; Harding, J.; Voss, M.; Mier, J.; DeMichele, A.; Munster, P.; Patel, M.; Iliopoulos, O.; Owonikoko, T.; Whiting, S.; Orford, K.; Bennett, M.; Carvajal, R.; McKay, R.; Fan, A.; Telli, M.; Infante, J. 分享 收藏
CB-839, a selective glutaminase inhibitor, has anti-tumor activity in renal cell carcinoma and synergizes with everolimus and receptor tyrosine kinase inhibitors Emberley, E.; Bennett, M.; Chen, J.; Gross, M.; Huang, T.; Li, W.; Mackinnon, A.; Pan, A.; Rodriguez, M.; Steggerda, S.; Wang, T.; Zhang, J.; Zhang, W.; Parlati, F. 分享 收藏
Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin Yu, Shirong; Evans, Katie; van Eijk, Patrick; Bennett, Mark; Webster, Richard M.; Leadbitter, Matthew; Teng, Yumin; Waters, Raymond; Jackson, Stephen P.; Reed, Simon H. 分享 收藏
Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response Works, Melissa; Bennett, Mark; Chen, Jason; Emberley, Ethan; Huang, Tony; Janes, Julie; Li, Weiqun; Mackinnon, Andy; Marguier, Gisele; Neou, Silinda; Pan, Alison; Parlati, Francesco; Rodriguez, Mirna; Steggerda, Susanne; Wang, Tracy; Zhang, Jing; Zhang, Winter; Gross, Matthew 分享 收藏
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CB-839, a selective glutaminase inhibitor, synergizes with signal transduction pathway inhibitors to enhance anti-tumor activity Rodriguez, Mirna; Zhang, Winter; Bennett, Mark; Emberley, Ethan; Gross, Mathew; Janes, Julie; MacKinnon, Andrew; Pan, Alison; Steggerda, Susanne; Works, Melissa; Parlati, Francesco 分享 收藏
A novel pharmacodynamic assay to measure glutaminase inhibition following oral administration of CB-839 in triple negative breast cancer biopsies MacKinnon, Andy; Bennett, Mark; Emberley, Ethan; Gross, Mathew; Janes, Julie; Lewis, Evan; Pan, Alison; Rodriguez, Mirna; Shwonek, Peter; Wang, Taotao; Yang, Jinfu; Zhao, Frances; Parlati, Francesco 分享 收藏
CB-839, a novel potent and selective glutaminase inhibitor, has broad antiproliferative activity in cell lines derived from both solid tumors and hematological malignancies Parlati, Francesco; Demo, Susan D.; Gross, Matthew I.; Janes, Julie R.; Lewis, Evan R.; MacKinnon, Andy L.; Rodriguez, Mirna L. M.; Shwonek, Peter J.; Wang, Taotao; Yang, Jinfu; Zhang, Dong; Zhao, Frances; Bennett, Mark K. 分享 收藏
Novel pharmacodynamic assays to measure glutaminase inhibition following oral administration of CB-839 MacKinnon, Andy L.; Bennett, Mark K.; Gross, Matthew I.; Janes, Julie R.; Lewis, Evan R.; Rodriguez, Mirna L. M.; Shwonek, Peter J.; Taotao, Wang; Yang, Jinfu; Zhao, Frances; Parlati, Francesco 分享 收藏
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer Gross, Matt I.; Demo, Susan D.; Dennison, Jennifer B.; Chen, Lijing; Chernov-Rogan, Tania; Goyal, Bindu; Janes, Julie R.; Laidig, Guy J.; Lewis, Evan R.; Li, Jim; MacKinnon, Andrew L.; Parlati, Francesco; Rodriguez, Mirna L. M.; Shwonek, Peter J.; Sjogren, Eric B.; Stanton, Timothy F.; Wang, Taotao; Yang, Jinfu; Zhao, Frances; Bennett, Mark K. 分享 收藏
Preclinical antitumor activity of novel small molecule glutaminase inhibitors in triple-negative breast cancer. Demo, Susan; Chernov-Rogan, Tania; Gross, Matthew; Janes, Julie; Kawas, Raja; Lewis, Evan; Parlati, Francesco; Rodriguez, Hector; Rodriguez, Mirna; Yang, Jinfu; Zhao, Frances; Richardson, Adam; Bennett, Mark K. 分享 收藏
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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis (vol 15, pg 781, 2009) Muchamuel, Tony; Basler, Michael; Aujay, Monette A.; Suzuki, Erika; Kalim, Khalid W.; Lauer, Christoph; Sylvain, Catherine; Ring, Eileen R.; Shields, Jamie; Jiang, Jing; Shwonek, Peter; Parlati, Francesco; Demo, Susan D.; Bennett, Mark K.; Kirk, Christopher J.; Groettrup, Marcus 分享 收藏
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis Muchamuel, Tony; Basler, Michael; Aujay, Monette A.; Suzuki, Erika; Kalim, Khalid W.; Lauer, Christoph; Sylvain, Catherine; Ring, Eileen R.; Shields, Jamie; Jiang, Jing; Shwonek, Peter; Parlati, Francesco; Demo, Susan D.; Bennett, Mark K.; Kirk, Christopher J.; Groettrup, Marcus 分享 收藏
Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047) Zhou, Han-Jie; Aujay, Monette A.; Bennett, Mark K.; Dajee, Maya; Demo, Susan D.; Fang, Ying; Ho, Mark N.; Jiang, Jing; Kirk, Christopher J.; Laidig, Guy J.; Lewis, Evan R.; Lu, Yan; Muchamuel, Tony; Parlati, Francesco; Ring, Eileen; Shenk, Kevin D.; Shields, Jamie; Shwonek, Peter J.; Stanton, Timothy; Sun, Congcong M.; Sylvain, Catherine; Woo, Tina M.; Yang, Jinfu 分享 收藏
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