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Article A bacterial genotoxin reveals a p53-proteasomeLC3 regulatory axis that drives the suppression of autophagy in cells experiencing sublethal DNA damage 文章 A：一种细菌基因毒素揭示了一个p53-蛋白酶体LC3调控轴，该轴驱动在经历亚致死性DNA损伤的细胞中自噬的抑制。 Lieu, D'Feau J.; Crowder, Molly K.; Kryza, Jordan R.; Tamilselvam, Batcha; Kaminski, Paul J.; Kim, Ik-Jung; Li, Ying-Xing; Jeong, Eunji; Enkhbaatar, Michidmaa; Chen, Henry; Son, Sophia B.; Mok, Hanlin; Bradley, Kenneth A.; Phillips, Heidi; Blanke, Steven R. 分享 收藏
Antiviral target compound profile for pandemic preparedness Demarest, James F.; Draghia-Akli, Ruxandra; Cihlar, Tomas; Bradley, Kenneth; Young, John A. T.; Chandra, Richa; Vaidyanathan, Sujata; Chu-Moyer, Margaret; Lynch, Christopher L.; Campbell, Andrew; Saikatendu, Kumar Singh; Bilello, John P.; Murata, Yoshihiko; van Loock, Marnix; Hurt, Aeron C.; Tellinghuisen, Timothy; Ruggiero, Lee; Mackman, Richard; Hill, Nina M.; Pottage, John C.; van Loock, Marnix 分享 收藏
In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax Shilman, Mikhail Martchenko; Bartolo, Gloria; Alameh, Saleem; Peterson, Johnny W.; Lawrence, William S.; Peel, Jennifer E.; Sivasubramani, Satheesh K.; Beasley, David W. C.; Cote, Christopher K.; Demons, Samandra T.; Halasahoris, Stephanie A.; Miller, Lynda L.; Klimko, Christopher P.; Shoe, Jennifer L.; Fetterer, David P.; McComb, Ryan; Ho, Chi-Lee C.; Bradley, Kenneth A.; Hartmann, Stella; Cheng, Luisa W.; Chugunova, Marina; Kao, Chiu-Yen; Tran, Jennifer K.; Derbedrossian, Aram; Zilbermintz, Leeor; Amali-Adekwu, Emiene; Levitin, Anastasia; West, Joel 分享 收藏
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV Hu, Yimin; Shi, Houguang; Zhou, Mingwei; Ren, Qingcheng; Zhu, Wei; Zhang, Weixing; Zhang, Zhiwei; Zhou, Chengang; Liu, Yongqiang; Ding, Xiao; Shen, Hong C.; Yan, S. Frank; Dey, Fabian; Wu, Waikwong; Zhai, Guanglei; Zhou, Zheng; Xu, Zhiheng; Ji, Ying; Lv, Hua; Jiang, Tianyi; Wang, Wen; Xu, Yunhua; Vercruysse, Maarten; Yao, Xiangyu; Mao, Yi; Yu, Xiaomin; Bradley, Kenneth; Tan, Xuefei 分享 收藏
Machine learning-powered antibiotics phenotypic drug discovery Zoffmann, Sannah; Vercruysse, Maarten; Benmansour, Fethallah; Maunz, Andreas; Wolf, Luise; Marti, Rita Blum; Heckel, Tobias; Ding, Haiyuan; Truong, Hoa Hue; Prummer, Michael; Schmucki, Roland; Mason, Clive S.; Bradley, Kenneth; Jacob, Asha Ivy; Lerner, Christian; del Rosario, Andrea Araujo; Burcin, Mark; Amrein, Kurt E.; Prunotto, Marco 分享 收藏
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Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting Zilbermintz, Leeor; Leonardi, William; Jeong, Sun-Young; Sjodt, Megan; McComb, Ryan; Ho, Chi-Lee C.; Retterer, Cary; Gharaibeh, Dima; Zamani, Rouzbeh; Soloveva, Veronica; Bavari, Sina; Levitin, Anastasia; West, Joel; Bradley, Kenneth A.; Clubb, Robert T.; Cohen, Stanley N.; Gupta, Vivek; Martchenko, Mikhail 分享 收藏
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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses Gillespie, Eugene J.; Ho, Chi-Lee C.; Balaji, Kavitha; Clemens, Daniel L.; Deng, Gang; Wang, Yao E.; Elsaesser, Heidi J.; Tamilselvam, Batcha; Gargi, Amandeep; Dixon, Shandee D.; France, Bryan; Chamberlain, Brian T.; Blanke, Steven R.; Cheng, Genhong; de la Torre, Juan Carlos; Brooks, David G.; Jung, Michael E.; Colicelli, John; Damoiseaux, Robert; Bradley, Kenneth A. 分享 收藏
Cellular Interactions of the Cytolethal Distending Toxins from Escherichia coli and Haemophilus ducreyi Gargi, Amandeep; Tamilselvam, Batcha; Powers, Brendan; Prouty, Michael G.; Lincecum, Tommie; Eshraghi, Aria; Maldonado-Arocho, Francisco J.; Wilson, Brenda A.; Bradley, Kenneth A.; Blanke, Steven R. 分享 收藏
Genome-Wide Bacterial Toxicity Screening Uncovers the Mechanisms of Toxicity of a Cationic Polystyrene Nanomaterial Ivask, Angela; Suarez, Elizabeth; Patel, Trina; Boren, David; Ji, Zhaoxia; Holden, Patricia; Telesca, Donatello; Damoiseaux, Robert; Bradley, Kenneth A.; Godwin, Hilary 分享 收藏
Allelic Variation on Murine Chromosome 11 Modifies Host Inflammatory Responses and Resistance to Bacillus anthracis Terra, Jill K.; France, Bryan; Cote, Christopher K.; Jenkins, Amy; Bozue, Joel A.; Welkos, Susan L.; Bhargava, Ragini; Ho, Chi-Lee; Mehrabian, Margarete; Pan, Calvin; Lusis, Aldons J.; Davis, Richard C.; LeVine, Steven M.; Bradley, Kenneth A. 分享 收藏
A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells Visnyei, Koppany; Onodera, Hideyuki; Damoiseaux, Robert; Saigusa, Kuniyasu; Petrosyan, Syuzanna; De Vries, David; Ferrari, Denise; Saxe, Jonathan; Panosyan, Eduard H.; Masterman-Smith, Michael; Mottahedeh, Jack; Bradley, Kenneth A.; Huang, Jing; Sabatti, Chiara; Nakano, Ichiro; Kornblum, Harley I. 分享 收藏
Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells Zhang, Haiyuan; Xia, Tian; Meng, Huan; Xue, Min; George, Saji; Ji, Zhaoxia; Wang, Xiang; Liu, Rong; Wang, Meiying; France, Bryan; Rallo, Robert; Damoiseaux, Robert; Cohen, Yoram; Bradley, Kenneth A.; Zink, Jeffrey I.; Nel, Andre E. 分享 收藏
Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials 使用高通量筛选方法结合体内斑马鱼胚胎筛选来开发工程纳米材料的危害等级 George, Saji; Xia, Tian; Rallo, Robert; Zhao, Yan; Ji, Zhaoxia; Lin, Sijie; Wang, Xiang; Zhang, Haiyuan; France, Bryan; Schoenfeld, David; Damoiseaux, Robert; Liu, Rong; Lin, Shuo; Bradley, Kenneth A.; Cohen, Yoram; Nel, Andre E. 分享 收藏
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