未登录 Antimalarial Dibenzannulated Medium-Ring Keto Lactams Ren, Rongguo; Wang, Xiaofang; Leas, Derek A.; Scheurer, Christian; Hoevel, Sarah; Cal, Monica; Chen, Gong; Zhong, Longjin; Katneni, Kasiram; Pham, Thao; Patil, Rahul; Sil, Diptesh; Walters, Matthias J.; Schulze, Thomas T.; Neville, Andrew J.; Dong, Yuxiang; Wittlin, Sergio; Kaiser, Marcel; Davis, Paul H.; Charman, Susan A.; Vennerstrom, Jonathan L. 分享 收藏
A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme Ling, Dawson B.; Nguyen, William; Looker, Oliver; Razook, Zahra; Mccann, Kirsty; Barry, Alyssa E.; Scheurer, Christian; Wittlin, Sergio; Famodimu, Mufuliat Toyin; Delves, Michael J.; Bullen, Hayley E.; Crabb, Brendan S.; Sleebs, Brad E.; Gilson, Paul R. 分享 收藏
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439 合成过氧化物抗疟药OZ439的细胞色素P450-Mediated代谢和CYP抑制 Shackleford, David M.; Chiu, Francis C. K.; Katneni, Kasiram; Blundell, Scott; McLaren, Jenna; Wang, Xiaofang; Zhou, Lin; Sriraghavan, Kamaraj; Alker, Andre M.; Hunziker, Daniel; Scheurer, Christian; Zhao, Qingjie; Dong, Yuxiang; Moehrle, Joerg J.; Abla, Nada; Matile, Hugues; Wittlin, Sergio; Vennerstrom, Jonathan L.; Charman, Susan A. 分享 收藏
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Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum Schalkwijk, Joost; Allman, Erik L.; Jansen, Patrick A. M.; de Vries, Laura E.; Verhoef, Julie M. J.; Jackowski, Suzanne; Botman, Peter N. M.; Beuckens-Schortinghuis, Christien A.; Koolen, Karin M. J.; Bolscher, Judith M.; Vos, Martijn W.; Miller, Karen; Reeves, Stacy A.; Pett, Helmi; Trevitt, Graham; Wittlin, Sergio; Scheurer, Christian; Sax, Sibylle; Fischli, Christoph; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Josling, Gabrielle; Kooij, Taco W. A.; Bonnert, Roger; Campo, Brice; Blaauw, Richard H.; Rutjes, Floris P. J. T.; Sauerwein, Robert W.; Llinas, Manuel; Hermkens, Pedro H. H.; Dechering, Koen J. 分享 收藏
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase Paquet, Tanya; Le Manach, Claire; Cabrera, Diego Gonzalez; Younis, Yassir; Henrich, Philipp P.; Abraham, Tara S.; Lee, Marcus C. S.; Basak, Rajshekhar; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Bantscheff, Marcus; Ruecker, Andrea; Blagborough, Andrew M.; Zakutansky, Sara E.; Zeeman, Anne-Marie; White, Karen L.; Shackleford, David M.; Mannila, Janne; Morizzi, Julia; Scheurer, Christian; Angulo-Barturen, Inigo; Martinez, Maria Santos; Ferrer, Santiago; Sanz, Laura Maria; Gamo, Francisco Javier; Reader, Janette; Botha, Mariette; Dechering, Koen J.; Sauerwein, Robert W.; Tungtaeng, Anchalee; Vanachayangkul, Pattaraporn; Lim, Chek Shik; Burrows, Jeremy; Witty, Michael J.; Marsh, Kennan C.; Bodenreider, Christophe; Rochford, Rosemary; Solapure, Suresh M.; Jimenez-Diaz, Mara Belen; Wittlin, Sergio; Charman, Susan A.; Donini, Cristina; Campo, Brice; Birkholtz, Lyn-Marie; Hanson, Kirsten K.; Drewes, Gerard; Kocken, Clemens H. M.; Delves, Michael J.; Leroy, Didier; Fidock, David A.; Waterson, David; Street, Leslie J.; Chibale, Kelly 分享 收藏
Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) Dong, Yuxiang; Wang, Xiaofang; Kamaraj, Sriraghavan; Bulbule, Vivek J.; Chiu, Francis C. K.; Chollet, Jacques; Dhanasekaran, Manickam; Hein, Christopher D.; Papastogiannidis, Petros; Morizzi, Julia; Shackleford, David M.; Barker, Helena; Ryan, Eileen; Scheurer, Christian; Tang, Yuanqing; Zhao, Qingjie; Zhou, Lin; White, Karen L.; Urwyler, Heinrich; Charman, William N.; Matile, Hugues; Wittlin, Sergio; Charman, Susan A.; Vennerstrom, Jonathan L. 分享 收藏
Identification and Deconvolution of Cross-Resistance Signals from Antimalarial Compounds Using Multidrug-Resistant Plasmodium falciparum Strains Chugh, Monika; Scheurer, Christian; Sax, Sibylle; Bilsland, Elizabeth; van Schalkwyk, Donelly A.; Wicht, Kathryn J.; Hofmann, Natalie; Sharma, Anil; Bashyam, Sridevi; Singh, Shivendra; Oliver, Stephen G.; Egan, Timothy J.; Malhotra, Pawan; Sutherland, Colin J.; Beck, Hans-Peter; Wittlin, Sergio; Spangenberg, Thomas; Ding, Xavier C. 分享 收藏
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Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres Wang, Xiaofang; Dong, Yinxiang; Wittlin, Sergio; Charman, Susan A.; Chiu, Francis C. K.; Chollet, Jacques; Katneni, Kasiram; Mannila, Janne; Morizzi, Julia; Ryan, Eileen; Scheurer, Christian; Steuten, Jessica; Tomas, Josefina Santo; Snyder, Christopher; Vennerstrom, Jonathan L. 分享 收藏
Structure-Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines Cabrera, Diego Gonzalez; Douelle, Frederic; Younis, Yassir; Feng, Tzu-Shean; Le Manach, Claire; Nchinda, Aloysius T.; Street, Leslie J.; Scheurer, Christian; Kamber, Jolanda; White, Karen L.; Montagnat, Oliver D.; Ryan, Eileen; Katneni, Kasiram; Zabiulla, K. Mohammed; Joseph, Jayan T.; Bashyam, Sridevi; Waterson, David; Witty, Michael J.; Charman, Susan A.; Wittlin, Sergio; Chibale, Kelly 分享 收藏
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria Charman, Susan A.; Arbe-Barnes, Sarah; Bathurst, Ian C.; Brun, Reto; Campbell, Michael; Charman, William N.; Chiu, Francis C. K.; Chollet, Jacques; Craft, J. Carl; Creek, Darren J.; Dong, Yuxiang; Matile, Hugues; Maurer, Melanie; Morizzi, Julia; Nguyen, Tien; Papastogiannidis, Petros; Scheurer, Christian; Shackleford, David M.; Sriraghavan, Kamaraj; Stingelin, Lukas; Tang, Yuanqing; Urwyler, Heinrich; Wang, Xiaofang; White, Karen L.; Wittlin, Sergio; Zhou, Lin; Vennerstrom, Jonathan L. 分享 收藏
Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum Geist, Julie G.; Lauw, Susan; Illarionova, Victoria; Illarionov, Boris; Fischer, Markus; Graewert, Tobias; Rohdich, Felix; Eisenreich, Wolfgang; Kaiser, Johannes; Groll, Michael; Scheurer, Christian; Wittlin, Sergio; Alonso-Gomez, Jose L.; Schweizer, W. Bernd; Bacher, Adelbert; Diederich, Francois 分享 收藏
The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277) Dong, Yuxiang; Wittlin, Sergio; Sriraghavan, Kamaraj; Chollet, Jacques; Charman, Susan A.; Charman, William N.; Scheurer, Christian; Urwyler, Heinrich; Tomas, Josefina Santo; Snyder, Christopher; Creek, Darren J.; Morizzi, Julia; Koltun, Maria; Matile, Hugues; Wang, Xiaofang; Padmanilayam, Maniyan; Tang, Yuanqing; Dorn, Arnulf; Brun, Reto; Vennerstrom, Jonathan L. 分享 收藏
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Spiro- and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides Wang, Xiaofang; Dong, Yuxiang; Wittlin, Sergio; Creek, Darren; Chollet, Jacques; Charman, Susan A.; Santo Tomas, Josefina; Scheurer, Christian; Snyder, Christopher; Vennerstrom, Jonathan L. 分享 收藏
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes Dong, Yuxiang; Tang, Yuanqing; Chollet, Jacques; Matile, Hugues; Wittlin, Sergio; Charman, Susan A.; Charman, William N.; Tomas, Josefina Santo; Scheurer, Christian; Snyder, Christopher; Scorneaux, Bernard; Bajpai, Saroi; Alexander, Scott A.; Wang, Xiaofang; Padmanilayam, Manlyan; Cheruku, Srinivasa R.; Brun, Reto; Vennerstrom, Jonathan L. 分享 收藏
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes Dong, YX; Chollet, J; Matile, H; Charman, SA; Chiu, FCK; Charman, WN; Scorneaux, B; Urwyler, H; Tomas, JS; Scheurer, C; Snyder, C; Dorn, A; Wang, XF; Karle, JM; Tang, YQ; Wittlin, S; Brun, R; Vennerstrom, JL 分享 收藏
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