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Molecular characterization of newly diagnosed acute myeloid leukemia patients aged 60 years or older: a report from the Beat AML clinical trial 新诊断急性髓系白血病60岁及以上患者的分子特征分析：Beat AML临床试验报告 Hoff, Fieke W.; Huang, Ying; Welkie, Rina Li; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Patel, Prapti A.; Collins Jr, Robert H.; Baer, Maria R.; Duong, Vu H.; Blum, William G.; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca L.; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja G.; Rosenberg, Leonard; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Yocum, Ashley O.; Borate, Uma M.; Mims, Alice S.; Byrd, John C.; Madanat, Yazan F. 分享 收藏
IDH2 Mutation Is Associated with Favorable Outcome Among Older Adults with Newly Diagnosed Acute Myeloid Leukemia Treated with Lower-Intensity Therapy IDH2突变与接受低强度治疗的新诊断急性髓系白血病老年患者的良好预后相关。 Hoff, Fieke W.; Huang, Ying; Li Welkie, Rina; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Patel, Prapti A.; Collins, Robert H.; Baer, Maria R.; Duong, Vu H.; Blum, William; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor J.; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja Gullen; Rosenberg, Leonard; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Yocum, Ashley Owen; Borate, Uma; Mims, Alice; Byrd, John C.; Madanat, Yazan F. 分享 收藏
Outcomes and Survival in Newly Diagnosed, Older, Acute Myeloid Leukemia Patients from the Beat AML Master Trial in the Venetoclax/Azacitidine Age 新诊断、老年急性髓系白血病患者在Venetoclax/阿扎胞苷时代的Beat AML主试验中的结局与生存情况 Borate, Uma; Huang, Ying; Li Welkie, Rina; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Madanat, Yazan F.; Patel, Prapti A.; Collins, Robert H.; Baer, Maria R.; Duong, Vu H.; Blum, William; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor J.; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja Gullen; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Rossenber, Leohard; Yocum, Ashley Owen; Mims, Alice; Byrd, John C. 分享 收藏
Pentostatin Low-Dose TBI Is an Effective Conditioning Regimen That Permits Donor Engraftment in Patients with High Co-Morbidities Undergoing the First Transplant or Prior to a Second Transplant Pentostatin低剂量TBI是一种有效的预处理方案，可在初次移植或二次移植前允许具有高合并症的患者实现供者植入。 Gvajaia, Ani; Rimando, Joseph; Blum, William; Vale, Colin A.; Giver, Cynthia R.; Corbett, Elaina L.; Hall, Kevin; Murphy, Kristina; Lechowicz, Mary Jo; Conn, Michel; Surati, Minal; Qayed, Muna; Langston, Amelia; Waller, Edmund K. 分享 收藏
A Randomized Phase 2 Trial of 28-Day (Arm A) Versus 14-Day (Arm B) Schedule of Venetoclax plus Azacitidine in Newly Diagnosed Acute Myeloid Leukemia Patients ≥ 60 Years 一项随机Ⅱ期临床试验，比较28天（A组）与14天（B组）方案下Venetoclax联合Azacitidine治疗初诊急性髓系白血病患者（≥60岁）的效果。 Borate, Uma; Huang, Ying; Zeidner, Joshua F.; Swords, Ronan T.; Koenig, Kristin L.; Stein, Eytan M.; Baer, Maria R.; Stock, Wendy; Madanat, Yazan F.; Olin, Rebecca; Blum, William; Schiller, Gary J.; Lin, Tara L.; Curran, Emily K.; Martycz, Molly; Rosenberg, Leonard; Marcus, Sonja Gullen; Chen, Timothy; Stefanos, Mona; Levine, Ross L.; Druker, Brian J.; Yocum, Ashley Owen; Burd, Amy; Mims, Alice; Byrd, John C. 分享 收藏
Beat-AML 2024 ELN-refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy Beat-aml 2024 ELN-对新诊断AML的老年人进行低强度治疗的风险分层 Hoff, Fieke W.; Blum, William G.; Huang, Ying; Li Welkie, Rina; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Archer, Kellie J.; Patel, Prapti A.; Collins, Robert H.; Baer, Maria R.; Duong, Vu H.; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca L.; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja G.; Rosenberg, Leonard; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Yocum, Ashley O.; Borate, Uma M.; Mims, Alice S.; Byrd, John C.; Madanat, Yazan F. 分享 收藏
A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2-mutant AML 评估enasidenib和适应风险的阿扎胞苷添加对新诊断的IDH2-mutant AML的疗效的研究 Cai, Sheng F.; Huang, Ying; Lance, Jennie R.; Mao, Hsiaoyin Charlene; Dunbar, Andrew J.; McNulty, Samantha N.; Druley, Todd; Li, Yan; Baer, Maria R.; Stock, Wendy; Kovacsovics, Tibor; Blum, William G.; Schiller, Gary J.; Olin, Rebecca L.; Foran, James M.; Litzow, Mark; Lin, Tara; Patel, Prapti; Foster, Matthew C.; Boyiadzis, Michael; Collins, Robert H.; Chervin, Jordan; Shoben, Abigail; Vergilio, Jo-Anne; Heerema, Nyla A.; Rosenberg, Leonard; Chen, Timothy L.; Yocum, Ashley O.; Druggan, Franchesca; Marcus, Sonja; Stefanos, Mona; Druker, Brian J.; Mims, Alice S.; Borate, Uma; Burd, Amy; Byrd, John C.; Levine, Ross L.; Stein, Eytan M. 分享 收藏
Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG) Ozga, Michael; Nicolet, Deedra; Mrozek, Krzysztof; Yilmaz, Ayse S.; Kohlschmidt, Jessica; Larkin, Karilyn T.; Blachly, James S.; Oakes, Christopher C.; Buss, Jill; Walker, Christopher J.; Orwick, Shelley; Jurinovic, Vindi; Rothenberg-Thurley, Maja; Dufour, Annika; Schneider, Stephanie; Sauerland, Maria Cristina; Goerlich, Dennis; Krug, Utz; Berdel, Wolfgang E.; Woermann, Bernhard J.; Hiddemann, Wolfgang; Braess, Jan; Subklewe, Marion; Spiekermann, Karsten; Carroll, Andrew J.; Blum, William G.; Powell, Bayard L.; Kolitz, Jonathan E.; Moore, Joseph O.; Mayer, Robert J.; Larson, Richard A.; Uy, Geoffrey L.; Stock, Wendy; Metzeler, Klaus H.; Grimes, H. Leighton; Byrd, John C.; Salomonis, Nathan; Herold, Tobias; Mims, Alice S.; Eisfeld, Ann-Kathrin 分享 收藏
Samples from patients with AML show high concordance in detection of mutations by NGS at local institutions vs central laboratories 来自AML患者的样本在地方机构与中央实验室的NGS检测突变方面显示出高度一致性 Borate, Uma; Yang, Fei; Press, Richard; Ruppert, Amy S.; Jones, Dan; Caruthers, Sean; Zhao, Weiqiang; Vergilio, Jo-Anne; Pavlick, Dean C.; Juckett, Luke; Norris, Brianna; Bucy, Taylor; Burd, Amy; Stein, Eytan M.; Patel, Prapti; Baer, Maria R.; Stock, Wendy; Schiller, Gary; Blum, William; Kovacsovics, Tibor; Litzow, Mark; Foran, James; Heerema, Nyla A.; Rosenberg, Leonard; Marcus, Sonja; Yocum, Ashley; Stefanos, Mona; Druker, Brian; Byrd, John C.; Levine, Ross L.; Mims, Alice 分享 收藏
Association of social deprivation with survival in younger adult patients with AML: an Alliance study Rebechi, Melanie; Kohlschmidt, Jessica; Mrozek, Krzysztof; Nicolet, Deedra; Mims, Alice S.; Blachly, James S.; Orwick, Shelley; Larkin, Karilyn T.; Oakes, Christopher C.; Hantel, Andrew; Carroll, Andrew J.; Blum, William G.; Powell, Bayard L.; Uy, Geoffrey L.; Stone, Richard M.; Larson, Richard A.; Byrd, John C.; Paskett, Electra D.; Plascak, Jesse J.; Eisfeld, Ann-Kathrin 分享 收藏
Olutasidenib (FT-2102) induces durable complete remissions in patients with relapsed or refractory IDH1-mutated AML Olutasidenib (FT-2102) 可诱导复发或难治性IDH1-mutated AML患者持久完全缓解 de Botton, Stephane; Fenaux, Pierre; Yee, Karen; Recher, Christian; Wei, Andrew H.; Montesinos, Pau; Taussig, David C.; Pigneux, Arnaud; Braun, Thorsten; Curti, Antonio; Grove, Carolyn; Jonas, Brian A.; Khwaja, Asim; Legrand, Ollivier; Peterlin, Pierre; Arnan, Montserrat; Blum, William; Cilloni, Daniela; Hiwase, Devendra K.; Jurcic, Joseph G.; Krauter, Juergen; Thomas, Xavier; Watts, Justin M.; Yang, Jay; Polyanskaya, Olga; Brevard, Julie; Sweeney, Jennifer; Barrett, Emma; Cortes, Jorge 分享 收藏
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates Saliba, Antoine N.; Kaufmann, Scott H.; Stein, Eytan M.; Patel, Prapti A.; Baer, Maria R.; Stock, Wendy; Deininger, Michael; Blum, William; Schiller, Gary J.; Olin, Rebecca L.; Litzow, Mark R.; Lin, Tara L.; Ball, Brian J.; Boyiadzis, Michael M.; Traer, Elie; Odenike, Olatoyosi; Arellano, Martha L.; Walker, Alison; Duong, Vu H.; Kovacsovics, Tibor; Collins, Robert H.; Shoben, Abigail B.; Heerema, Nyla A.; Foster, Matthew C.; Peterson, Kevin L.; Schneider, Paula A.; Martycz, Molly; Gana, Theophilus J.; Rosenberg, Leonard; Marcus, Sonja; Yocum, Ashley O.; Chen, Timothy; Stefanos, Mona; Mims, Alice S.; Borate, Uma; Burd, Amy; Druker, Brian J.; Levine, Ross L.; Byrd, John C.; Foran, James M. 分享 收藏
Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial Entospletinib联合地西他滨治疗TP53突变或复杂核型的急性髓系白血病: Beat AML Master试验的2期子研究 Duong, Vu H.; Ruppert, Amy S.; Mims, Alice S.; Borate, Uma; Stein, Eytan M.; Baer, Maria R.; Stock, Wendy; Kovacsovics, Tibor; Blum, William; Arellano, Martha L.; Schiller, Gary J.; Olin, Rebecca L.; Foran, James M.; Litzow, Mark R.; Lin, Tara L.; Patel, Prapti A.; Foster, Matthew C.; Redner, Robert L.; Al-Mansour, Zeina; Cogle, Christopher R.; Swords, Ronan T.; Collins, Robert H.; Vergilio, Jo-Anne; Heerema, Nyla A.; Rosenberg, Leonard; Yocum, Ashley O.; Marcus, Sonja; Chen, Timothy; Druggan, Franchesca; Stefanos, Mona; Gana, Theophilus J.; Shoben, Abigail B.; Druker, Brian J.; Burd, Amy; Byrd, John C.; Levine, Ross L.; Boyiadzis, Michael M. 分享 收藏
Outcome prediction by the 2022 European LeukemiaNet genetic-risk classification for adults with acute myeloid leukemia: an Alliance study Mrozek, Krzysztof; Kohlschmidt, Jessica; Blachly, James S.; Nicolet, Deedra; Carroll, Andrew J.; Archer, Kellie J.; Mims, Alice S.; Larkin, Karilyn T.; Orwick, Shelley; Oakes, Christopher C.; Kolitz, Jonathan E.; Powell, Bayard L.; Blum, William G.; Marcucci, Guido; Baer, Maria R.; Uy, Geoffrey L.; Stock, Wendy; Byrd, John C.; Eisfeld, Ann-Kathrin 分享 收藏
High early death rates, treatment resistance, and short survival of Black adolescents and young adults with AML Larkin, Karilyn T.; Nicolet, Deedra; Kelly, Benjamin J.; Mrozek, Krzysztof; LaHaye, Stephanie; Miller, Katherine E.; Wijeratne, Saranga; Wheeler, Gregory; Kohlschmidt, Jessica; Blachly, James S.; Mims, Alice S.; Walker, Christopher J.; Oakes, Christopher C.; Orwick, Shelley; Boateng, Isaiah; Buss, Jill; Heyrosa, Adrienne; Desai, Helee; Carroll, Andrew J.; Blum, William; Powell, Bayard L.; Kolitz, Jonathan E.; Moore, Joseph O.; Mayer, Robert J.; Larson, Richard A.; Stone, Richard M.; Paskett, Electra D.; Byrd, John C.; Mardis, Elaine R.; Eisfeld, Ann-Kathrin 分享 收藏
An open-label, phase I/II trial to determine the maximum tolerated dose and investigate safety, pharmacokinetics and efficacy of BI 836858, an unconjugated anti-CD33 monoclonal antibody, in combination with decitabine in patients with acute myeloid leukemia Fiedler, Walter; Montesinos, Pau; Schliemann, Christoph; Middeke, Jan; Vasu, Sumithira; Scholz, Christian W.; Esteve, Jordi; Mondal, Shoubhik; Rueter, Bjoern; Burkard, Ute; Osswald, Annika; Blum, William 分享 收藏
A phase I study of the fully human, fragment crystallizable-engineered, anti-CD-33 monoclonal antibody BI 836858 in patients with previously-treated acute myeloid leukemia Vasu, Sumithira; Altman, Jessica K.; Uy, Geoffrey L.; Tallman, Martin S.; Gojo, Ivana; Lozanski, Gerard; Burkard, Ute; Osswald, Annika; James, Pamela; Ruter, Bjorn; Blum, William 分享 收藏
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Chen, Dong; Xia, Siyuan; Zhang, Rukang; Li, Yuancheng; Famulare, Christopher A.; Fan, Hao; Wu, Rong; Wang, Mei; Zhu, Allen C.; Elf, Shannon E.; Su, Rui; Dong, Lei; Arellano, Martha; Blum, William G.; Mao, Hui; Lonial, Sagar; Stock, Wendy; Odenike, Olatoyosi; Le Beau, Michelle; Boggon, Titus J.; He, Chuan; Chen, Jianjun; Gao, Xue; Levine, Ross L.; Chen, Jing 分享 收藏
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