未登录TEAD inhibition by SW-682 potentiates activity of targeted therapies in NSCLC models
Chen, L.; Jove, V.; de Marval, P. Miliani; DuBose, R.; Saha, S.; Johnson, M.; Ahn, S.; Powell, K.; Liu, F.; Lawhorn, B.; Gwaltney, S.; Shao, W.; Lin, T. A. .png)
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收藏Rational combination of pan-TEAD inhibitor SW-682 and MEK inhibitor mirdametinib in head and neck squamous cell carcinomas leads to synergistic responseSchirmer, A.; Chen, L.; Celentano, L.; Chanelo, A.; Jove, V.; DuBose, R.; Saha, S.; Johnson, M.; Lawhorn, B.; Gwaltney, S.; Lin, T. A.; de Marval, P. Miliani 分享 收藏 A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma ModelsHillen, Hanne; Candi, Aurelie; Vanderhoydonck, Bart; Kowalczyk, Weronika; Sansores-Garcia, Leticia; Kesikiadou, Elena C.; Van Huffel, Leen; Spiessens, Lore; Nijs, Marnik; Soons, Erik; Haeck, Wanda; Klaassen, Hugo; Smets, Wim; Spieser, Stephane A.; Marchand, Arnaud; Chaltin, Patrick; Ciesielski, Fabrice; Debaene, Francois; Chen, Lei; Kamal, Adeela; Gwaltney, Stephen L.; Versele, Matthias; Halder, Georg A. 分享 收藏 SW-682: A novel TEAD inhibitor for the treatment of cancers bearing mutations in the Hippo signaling pathwayChen, Lei; de Marval, Paula Milani; Powell, Kendall; Johnson, Mark; Falls, Greg; Lawhorn, Brian; Candi, Aurelie; Kilonda, Amuri; Vanderhoydonck, Bart; Marchand, Arnaud; Versele, Matthias; Halder, Georg; Gwaltney, Stephen L.; Kamal, Adeela 分享 收藏 Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell HemoglobinMetcalf, Brian; Chuang, Chihyuan; Dufu, Kobina; Patel, Mira P.; Silva-Garcia, Abel; Johnson, Carl; Lu, Qing; Partridge, James R.; Patskovska, Larysa; Patskovsky, Yury; Almo, Steven C.; Jacobson, Matthew P.; Hua, Lan; Xu, Qing; Gwaltney, Stephen L., II; Yee, Calvin; Harris, Jason; Morgan, Bradley P.; James, Joyce; Xu, Donghong; Hutchaleelaha, Athiwat; Paulvannan, Kumar; Oksenberg, Donna; Li, Zhe 分享 收藏 Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IVZhang, Zhiyuan; Wallace, Michael B.; Feng, Jun; Stafford, Jeffrey A.; Skene, Robert J.; Shi, Lihong; Lee, Bumsup; Aertgeerts, Kathleen; Jennings, Andy; Xu, Rongda; Kassel, Daniel B.; Kaldor, Stephen W.; Navre, Marc; Webb, David R.; Gwaltney, Stephen L., II 分享 收藏 Discovery of alogliptin: A potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV (vol 50, pg 2297, 2007)Feng, Jun; Zhang, Zhiyuan; Wallace, Micahel B.; Stafford, Jeffrey A.; Stephen, W. Kaldor; Kassel, Danil B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney, Stephen L., II 分享 收藏 Discovery of alogliptin: A potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IVFeng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney, Stephen L., II 分享 收藏 Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors发现1，4-二氢茚并 [1，2-c] 吡唑作为一类新型有效和选择性的检查点激酶1抑制剂Tong, Yunsong; Claiborne, Akiyo; Stewart, Kent D.; Park, Chang; Kovar, Peter; Chen, Zehan; Credo, Robert B.; Gu, Wen-Zhen; Gwaltney, Stephen L., II; Judge, Russell A.; Zhang, Haiying; Rosenberg, Saul H.; Sham, Hing L.; Sowin, Thomas J.; Lin, Nan-horng 分享 收藏 New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor modelsSzczepankiewicz, BG; Liu, G; Jae, HS; Tasker, AS; Gunawardana, IW; von Geldern, TW; Gwaltney, SL; Wu-Wong, JR; Gehrke, L; Chiou, WJ; Credo, RB; Alder, JD; Nukkala, MA; Zielinski, NA; Jarvis, K; Mollison, KW; Frost, DJ; Bauch, JL; Hui, YH; Claiborne, AK; Li, Q; Rosenberg, SH 分享 收藏 分享 收藏 分享 收藏 
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