未登录 Unlocking Enhanced Immunity in Pancreatic Ductal Adenocarcinoma: Activins Interplay with CAF-Stroma Mechanisms Mccluney, Simon; Park, Danielle; Miller, Daniel; Bloxham, Robert; Mehic, Merima; de Vries, Emma; Wang, Xuelu; Wilkinson, Robert; Hunt, James; Hyvonen, Marko; Boeing, Stefan; Sarker, Debashis; Hill, Caroline 分享 收藏
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models Kaistha, Brajesh P.; Kar, Gozde; Dannhorn, Andreas; Watkins, Amanda; Opoku-Ansah, Grace; Ilieva, Kristina; Mullins, Stefanie; Anderton, Judith; Galvani, Elena; Garcon, Fabien; Lapointe, Jean-Martin; Brown, Lee; Hair, James; Slidel, Tim; Luheshi, Nadia; Ryan, Kelli; Hardaker, Elizabeth; Dovedi, Simon; Kumar, Rakesh; Wilkinson, Robert W.; Hammond, Scott A.; Eyles, Jim 分享 收藏
CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells CD73控制变形虫胰腺癌细胞中肌球蛋白II驱动的侵袭，转移和免疫抑制 Samain, Remi; Maiques, Oscar; Monger, Joanne; Lam, Hoyin; Candido, Juliana; George, Samantha; Ferrari, Nicola; Kohihammer, Leonie; Lunetto, Sophia; Varela, Adrian; Orgaz, Jose L.; Vilardell, Felip; Olsina, Jorge Juan; Matias-Guiu, Xavier; Sarker, Debashis; Biddle, Adrian; Balkwill, Frances R.; Eyles, Jim; Wilkinson, Robert W.; Kocher, Hemant M.; Calvo, Fernando; Wells, Claire M.; Sanz-Moreno, Victoria 分享 收藏
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A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression Gitto, Sarah B.; Whicker, Margaret; Davies, Gareth; Kumar, Sushil; Kinneer, Krista; Lewis, Arthur; Mamidi, Srinivas; Medvedev, Sergey; Anderton, Judith; Tang, Jessica; Ferman, Benjamin; Coats, Steve; Wilkinson, Robert W.; Brown, Eric J.; Powell, Daniel J.; Simpkins, Fiona 分享 收藏
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation 靶向DNA损伤反应成分可在ATM缺陷的癌细胞中诱导STING依赖性I型IFN反应增强，并驱动树突状细胞活化 Lopez-Pelaez, Marta; Young, Lucy; Vazquez-Chantada, Mercedes; Nelson, Nadine; Durant, Steve; Wilkinson, Robert W.; Poon, Edmund; Gaspar, Miguel; Valge-Archer, Viia; Smith, Paul; Dovedi, Simon J. 分享 收藏
Recombinant Newcastle Disease Virus Immunotherapy Drives Oncolytic Effects and Durable Systemic Antitumor Immunity Harper, James; Burke, Shannon; Travers, Jon; Rath, Nicola; Leinster, Andrew; Navarro, Christel; Franks, Ruth; Leyland, Rebecca; Mulgrew, Kathy; McGlinchey, Kelly; Brown, Lee; Dovedi, Simon J.; Koopmann, Jens-Oliver; Durham, Nicholas M.; Cheng, Xing; Jin, Hong; Eyles, Jim; Wilkinson, Robert W.; Carroll, Danielle 分享 收藏
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells 增强PD-1活化T细胞CTLA4阻断的单价双特异性PD-1/CTLA4抗体的设计和功效 Dovedi, Simon J.; Elder, Matthew J.; Yang, Chunning; Sitnikova, Suzanne, I; Irving, Lorraine; Hansen, Anna; Hair, James; Jones, Des C.; Hasani, Sumati; Wang, Bo; Im, Seock-Ah; Tran, Ben; Subramaniam, Deepa S.; Gainer, Shelby D.; Vashisht, Kapil; Lewis, Arthur; Jin, Xiaofang; Kentner, Stacy; Mulgrew, Kathy; Wang, Yaya; Overstreet, Michael G.; Dodgson, James; Wu, Yanli; Palazon, Asis; Morrow, Michelle; Rainey, Godfrey J.; Browne, Gareth J.; Neal, Frances; Murray, Thomas, V; Toloczko, Aleksandra D.; Dall'Acqua, William; Achour, Ikbel; Freeman, Daniel J.; Wilkinson, Robert W.; Mazor, Yariv 分享 收藏
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer Schofield, Darren J.; Percival-Alwyn, Jennifer; Rytelewski, Mateusz; Hood, John; Rothstein, Raymond; Wetzel, Leslie; McGlinchey, Kelly; Adjei, Grace; Watkins, Amanda; Machiesky, LeeAnn; Chen, Weimin; Andrews, John; Groves, Maria; Morrow, Michelle; Stewart, Ross A.; Leinster, Andrew; Wilkinson, Robert W.; Hammond, Scott A.; Luheshi, Nadia; Dobson, Claire; Oberst, Michael 分享 收藏
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action Austin, Mark; Burschowsky, Daniel; Chan, Denice T. Y.; Jenkinson, Lesley; Haynes, Stuart; Diamandakis, Agata; Seewooruthun, Chitra; Addyman, Alexandra; Fiedler, Sebastian; Ryman, Stephanie; Whitehouse, Jessica; Slater, Louise H.; Hadjinicolaou, Andreas V.; Gileadi, Uzi; Gowans, Ellen; Shibata, Yoko; Barnard, Michelle; Kaserer, Teresa; Sharma, Pooja; Luheshi, Nadia M.; Wilkinson, Robert W.; Vaughan, Tristan J.; Holt, Sarah V.; Cerundolo, Vincenzo; Carr, Mark D.; Groves, Maria A. T. 分享 收藏
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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation Chan, Denice T. Y.; Jenkinson, Lesley; Haynes, Stuart W.; Austin, Mark; Diamandakis, Agata; Burschowsky, Daniel; Seewooruthun, Chitra; Addyman, Alexandra; Fiedler, Sebastian; Ryman, Stephanie; Whitehouse, Jessica; Slater, Louise H.; Gowans, Ellen; Shibata, Yoko; Barnard, Michelle; Wilkinson, Robert W.; Vaughan, Tristan J.; Holt, Sarah, V; Cerundolo, Vincenzo; Carr, Mark D.; Groves, Maria A. T. 分享 收藏
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies Mullins, Stefanie R.; Vasilakos, John P.; Deschler, Katharina; Grigsby, Iwen; Gillis, Pete; John, Julius; Elder, Matthew J.; Swales, John; Timosenko, Elina; Cooper, Zachary; Dovedi, Simon J.; Leishman, Andrew J.; Luheshi, Nadia; Elvecrog, James; Tilahun, Ashenafi; Goodwin, Richard; Herbst, Ronald; Tomai, Mark A.; Wilkinson, Robert W. 分享 收藏
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MEDI1191, a novel IL-12 mRNA therapy for intratumoral injection to promote TH1 transformation of the patient tumor microenvironment Luheshi, Nadia; Hewitt, Susannah; Garcon, Fabien; Burke, Shannon; Watkins, Amanda; Arnold, Kristen; Zielinski, John; Martin, Philip; Sulikowski, Michael; Bagnall, Christopher; Lapointe, Jean-Martin; Moody, Gordon; Si, Han; Morehouse, Christopher; Wilkinson, Robert W.; Herbst, Ronald; Frederick, Joshua 分享 收藏
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A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity Nelson, Nadine; Lopez-Pelaez, Marta; Palazon, Asis; Poon, Edmund; De La Roche, Maike; Barry, Simon; Valge-Archer, Viia; Wilkinson, Robert W.; Dovedi, Simon J.; Smith, Paul D. 分享 收藏
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