Jason C. Young - Publications, H-index & Citations

Jason C. Young

McGill University

41H指数

82论文数

7.4K被引数

收录论文 42

发表时间

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

NATURE COMMUNICATIONS

IF15.7

2023-06-23

OAAI

Rodina, Anna; Xu, Chao; Digwal, Chander S. S.; Joshi, Suhasini; Patel, Yogita; Santhaseela, Anand R. R.; Bay, Sadik; Merugu, Swathi; Alam, Aftab; Yan, Pengrong; Yang, Chenghua; Roychowdhury, Tanaya; Panchal, Palak; Shrestha, Liza; Kang, Yanlong; Sharma, Sahil; Almodovar, Justina; Corben, Adriana; Alpaugh, Mary L. L.; Modi, Shanu; Guzman, Monica L. L.; Fei, Teng; Taldone, Tony; Ginsberg, Stephen D. D.; Erdjument-Bromage, Hediye; Neubert, Thomas A. A.; Manova-Todorova, Katia; Tsou, Meng-Fu Bryan; Young, Jason C. C.; Wang, Tai; Chiosis, Gabriela

Sorghum bicolor SbHSP110 has an elongated shape and is able of protecting against aggregation and replacing human HSPH1/HSP110 in refolding and disaggregation assays

BIOPOLYMERS

IF3.2

2023-02-24

OAAI

Franco, Juliana C.; Nogueira, Maria L. C.; Gandelini, Gabriela M.; Pinheiro, Glaucia M. S.; Goncalves, Conrado C.; Barbosa, Leandro R. S.; Young, Jason C.; Ramos, Carlos H. I.

The chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70

SCIENTIFIC REPORTS

IF3.9

2021-08-24

OAAI

Goncalves, Conrado C.; Sharon, Itai; Schmeing, T. Martin; Ramos, Carlos H., I; Young, Jason C.

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR HSC70及其共伴侣与CFTR上结构热点的选择性结合

SCIENTIFIC REPORTS

IF3.9

2020-03-06

OAAI

Baaklini, Imad; Goncalves, Conrado de Campos; Lukacs, Gergely L.; Young, Jason C.

Function, evolution, and structure of J-domain proteins J结构域蛋白的功能、进化和结构

CELL STRESS & CHAPERONES

IF3.2

2019-01-01

111

OAAI

Kampinga, Harm H.; Andreasson, Claes; Barducci, Alessandro; Cheetham, Michael E.; Cyr, Douglas; Emanuelsson, Cecilia; Genevaux, Pierre; Gestwicki, Jason E.; Goloubinoff, Pierre; Huerta-Cepas, Jaime; Kirstein, Janine; Liberek, Krzysztof; Mayer, Matthias P.; Nagata, Kazuhiro; Nillegoda, Nadinath B.; Pulido, Pablo; Ramos, Carlos; De los Rios, Paolo; Rospert, Sabine; Rosenzweig, Rina; Sahi, Chandan; Taipale, Mikko; Tomiczek, Bratlomiej; Ushioda, Ryo; Young, Jason C.; Zimmermann, Richard; Zylicz, Alicja; Zylicz, Maciej; Craig, Elizabeth A.; Marszalek, Jaroslaw

Membrane cholesterol as regulator of human rhomboid protease RHBDL4

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-10-01

OAAI

Paschkowsky, Sandra; Recinto, Sherilyn Junelle; Young, Jason C.; Bondar, Ana-Nicoleta; Munter, Lisa Marie

Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-08-01

OAAI

Menade, Marie; Kozlov, Guennadi; Trempe, Jean-Francois; Pande, Harshit; Shenker, Solomon; Wickremasinghe, Sihara; Li, Xinlu; Hojjat, Hamed; Dicaire, Marie-Josee; Brais, Bernard; McPherson, Peter S.; Wong, Michael J. H.; Young, Jason C.; Gehring, Kalle

Preclinical mechanistic and efficacy evaluation of a novel small molecule TLR7 agonist RO7020531 for the treatment of chronic hepatitis B

JOURNAL OF HEPATOLOGY

IF33

2018-04-01

PREAI

Dai, L.; Yu, X.; Yu, Y.; Gu, L.; Zhao, J.; Zhu, L.; Ottaviani, G.; Yun, H.; Ait-Goughoulte, M.; Ilnicka, M.; Xie, J.; Wang, L.; Feng, A.; Young, J.; Gao, L.

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

NATURE COMMUNICATIONS

IF15.7

2017-08-30

OAAI

Bagdany, Miklos; Veit, Guido; Fukuda, Ryosuke; Avramescu, Radu G.; Okiyoneda, Tsukasa; Baaklini, Imad; Singh, Jay; Sovak, Guy; Xu, Haijin; Apaja, Pirjo M.; Sattin, Sara; Beitel, Lenore K.; Roldan, Ariel; Colombo, Giorgio; Balch, William; Young, Jason C.; Lukacs, Gergely L.

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-02-01

OAAI

Hantouche, Christine; Williamson, Brittany; Valinsky, William C.; Solomon, Joshua; Shrier, Alvin; Young, Jason C.

Heat Shock Protein 90 kDa (Hsp90) Has a Second Functional Interaction Site with the Mitochondrial Import Receptor Tom70

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-09-01

OAAI

Zanphorlin, Leticia M.; Lima, Tatiani B.; Wong, Michael J.; Balbuena, Tiago S.; Minetti, Conceicao A. S. A.; Remeta, David P.; Young, Jason C.; Barbosa, Leandro R. S.; Gozzo, Fabio C.; Ramos, Carlos H. I.

The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels

DISEASE MODELS & MECHANISMS

IF3.3

2014-03-01

OAAI

Young, Jason C.

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-02-18

OAAI

Kang, Yanlong; Taldone, Tony; Patel, Hardik J.; Patel, Pallav D.; Rodina, Anna; Gozman, Alexander; Maharaj, Ronnie; Clement, Cristina C.; Patel, Maulik R.; Brodsky, Jeffrey L.; Young, Jason C.; Chiosis, Gabriela

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-02-18

OAAI

Taldone, Tony; Kang, Yanlong; Patel, Hardik J.; Patel, Maulik R.; Patel, Pallav D.; Rodina, Anna; Patel, Yogita; Gozman, Alexander; Maharaj, Ronnie; Clement, Cristina C.; Lu, Alvin; Young, Jason C.; Chiosis, Gabriela

A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate

JOURNAL OF CELL BIOLOGY

IF6.4

2014-02-03

OAAI

Binda, Chantal; Genier, Samuel; Cartier, Andreane; Larrivee, Jean-Francois; Stankova, Jana; Young, Jason C.; Parent, Jean-Luc

Expression and Purification of a Functional hERG Pore Domain for Biophysical and Electrophysiological Studies

BIOPHYSICAL JOURNAL

IF3.1

2014-01-01

OAAI

Beaugrand, Maiwenn; Kalsi, Sumit; Gravel, Andree E.; Johnson, Christopher D.; Wright, Neville; Young, Jason C.; de Planque, Maurits R. R.; Marcotte, Isabelle; Williamson, Philip T. F.

The DNAJA2 Substrate Release Mechanism Is Essential for Chaperone-mediated Folding DNAJA2底物释放机制对于伴侣介导的折叠至关重要

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-12-01

OAAI

Baaklini, Imad; Wong, Michael J. H.; Hantouche, Christine; Patel, Yogita; Shrier, Alvin; Young, Jason C.

Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70 in Vitro Suggests a Chaperone Displacement Mechanism

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-09-01

OAAI

Fan, Anna C. Y.; Kozlov, Guennadi; Hoegl, Annabelle; Marcellus, Richard C.; Wong, Michael J. H.; Gehring, Kalle; Young, Jason C.

OEP61 is a chaperone receptor at the plastid outer envelope OEP61是质体外膜的伴侣受体

BIOCHEMICAL JOURNAL

IF4.3

2011-07-27

OAAI

von Loeffelholz, Ottilie; Kriechbaumer, Verena; Ewan, Richard A.; Jonczyk, Rafal; Lehmann, Susann; Young, Jason C.; Abell, Ben M.

Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-07-01

OAAI

Warr, Matthew R.; Mills, John R.; Mai Nguyen; Lemaire-Ewing, Stephanie; Baardsnes, Jason; Sun, Karen L. W.; Malina, Abba; Young, Jason C.; Jeyaraju, Danny V.; O'Connor-McCourt, Maureen; Pellegrini, Luca; Pelletier, Jerry; Shore, Gordon C.

研究方向