John Orban - Publications, H-index & Citations

John Orban

Massachusetts General Hospital

36H指数

154论文数

4.3K被引数

收录论文 28

发表时间

Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer

SCIENCE ADVANCES

IF12.5

2023-10-13

OAAI

Mohanty, Atish; Nam, Arin; Srivastava, Saumya; Jones, Jeff; Lomenick, Brett; Singhal, Sharad S.; Guo, Linlin; Cho, Hyejin; Li, Aimin; Behal, Amita; Mirzapoiazova, Tamara; Massarelli, Erminia; Koczywas, Marianna; Arvanitis, Leonidas D.; Walser, Tonya; Villaflor, Victoria; Hamilton, Stanley; Mambetsariev, Isa; Sattler, Martin; Nasser, Mohd W.; Jain, Maneesh; Batra, Surinder K.; Soldi, Raffaella; Sharma, Sunil; Fakih, Marwan; Mohanty, Saswat Kumar; Mainan, Avijit; Wu, Xiwei; Chen, Yihong; He, Yanan; Chou, Tsui-Fen; Roy, Susmita; Orban, John; Kulkarni, Prakash; Salgia, Ravi

Reversible switching between two common protein folds in a designed system using only temperature

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-01-20

OAAI

Solomon, Tsega L.; He, Yanan; Sari, Nese; Chen, Yihong; Gallagher, D. Travis; Bryan, Philip N.; Orban, John

Engineering subtilisin proteases that specifically degrade active RAS

COMMUNICATIONS BIOLOGY

IF5.1

2021-03-05

OAAI

Chen, Yingwei; Toth, Eric A.; Ruan, Biao; Choi, Eun Jung; Simmerman, Richard; Chen, Yihong; He, Yanan; Wang, Ruixue; Godoy-Ruiz, Raquel; King, Harlan; Custer, Gregory; Gallagher, D. Travis; Rozak, David A.; Solomon, Melani; Muro, Silvia; Weber, David J.; Orban, John; Fuerst, Thomas R.; Bryan, Philip N.

Carfilzomib: A potential drug against cisplatin-resistant lung adenocarcinoma

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Nam, Arin; Mohanty, Atish; Bhattacharya, Supriyo; Srivastava, Saumya; Pangeni, Rajendra; Raz, Dan; Orban, John; Kulkarni, Prakash; Salgia, Ravi

The structural basis of T-cell receptor (TCR) activation: An enduring enigma

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-01-24

125

OAAI

Mariuzza, Roy A.; Agnihotri, Pragati; Orban, John

Allosteric Effects and Signal Transduction in the Peptide-MHC Binding to a Human T Cell Receptor

BIOPHYSICAL JOURNAL

IF3.1

2019-02-01

OAAI

Ma, Buyong; Orban, John P.; Mariuzza, Roy; Nussinov, Ruth

Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites 与人类抗病毒T细胞受体结合的肽-MHC (pMHC) 诱导pMHC-和CD3-binding位点之间的长距离变构通讯

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-10-01

OAAI

Rangarajan, Sneha; He, Yanan; Chen, Yihong; Kerzic, Melissa C.; Ma, Buyong; Gowthaman, Ragul; Pierce, Brian G.; Nussinov, Ruth; Mariuzza, Roy A.; Orban, John

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

JOURNAL OF CLINICAL MEDICINE

IF2.9

2018-06-17

OAAI

Salgia, Ravi; Jolly, Mohit Kumar; Dorff, Tanya; Lau, Clayton; Weninger, Keith; Orban, John; Kulkarni, Prakash

Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity 前列腺癌的表型可塑性，Bet-Hedging和雄激素独立性: 非遗传异质性的作用

FRONTIERS IN ONCOLOGY

IF3.3

2018-03-06

OAAI

Jolly, Mohit Kumar; Kulkarni, Prakash; Weninger, Keith; Orban, John; Levine, Herbert

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity 磷酸化诱导的内在无序蛋白的构象动力学及其在表型异质性中的潜在作用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-03-13

OAAI

Kulkarni, Prakash; Jolly, Mohit Kumar; Jia, Dongya; Mooney, Steven M.; Bhargava, Ajay; Kagohara, Luciane T.; Chen, Yihong; Hao, Pengyu; He, Yanan; Veltri, Robert W.; Grishaev, Alexander; Weninger, Keith; Levine, Herbert; Orban, John

Phosphorylation of the intrinsically disordered cancer/testis antigen PAGE4 by HIPK1 and CLK2 in prostate cancer

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Kagohara, Luciane T.; Mooney, Steven; Chen, Yihong; Orban, John; Kulkarni, Prakash; Veltri, Robert W.

Clinical commissioning of an in vivo range verification system for prostate cancer treatment with anterior and anterior oblique proton beams

PHYSICS IN MEDICINE AND BIOLOGY

IF3.4

2016-03-22

PREAI

Hoesl, M.; Deepak, S.; Moteabbed, M.; Jassens, G.; Orban, J.; Park, Y. K.; Parodi, K.; Bentefour, E. H.; Lu, H. M.

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-10-01

OAAI

He, Yanan; Chen, Yihong; Mooney, Steven M.; Rajagopalan, Krithika; Bhargava, Ajay; Sacho, Elizabeth; Weninger, Keith; Bryan, Philip N.; Kulkarni, Prakash; Orban, John

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-08-01

OAAI

He, Yanan; Rangarajan, Sneha; Kerzic, Melissa; Luo, Ming; Chen, Yihong; Wang, Qian; Yin, Yiyuan; Workman, Creg J.; Vignali, Kate M.; Vignali, Dario A. A.; Mariuzza, Roy A.; Orban, John

Subdomain Interactions Foster the Design of Two Protein Pairs with ∼80% Sequence Identity but Different Folds

BIOPHYSICAL JOURNAL

IF3.1

2015-01-01

OAAI

Porter, Lauren L.; He, Yanan; Chen, Yihong; Orban, John; Bryan, Philip N.

Protein Evolution across Fold Classes: A 3-α-Helix Bundle can Switch to β, α/β, and α plus β Folds by Stepwise Mutation

BIOPHYSICAL JOURNAL

IF3.1

2015-01-01

OAAI

Porter, Lauren L.; He, Yanan; Chen, Yihong; Orban, John; Bryan, Philip N.