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收藏Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
Quintana-Feliciano, Richard; Kottur, Jithesh; Ni, Mi; Ghosh, Rikhia; Salas-Estrada, Leslie; Ahlsen, Goran; Rechkoblit, Olga; Shapiro, Lawrence; Filizola, Marta; Fang, Gang; Aggarwal, Aneel K. 分享 收藏 Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitroXLF和XRCC4无序区域的多价相互作用可促进强大的细胞NHEJ并在体外驱动连接促进缩合物的形成Vu, Duc-Duy; Bonucci, Alessio; Breniere, Manon; Cisneros-Aguirre, Metztli; Pelupessy, Philippe; Wang, Ziqing; Carlier, Ludovic; Bouvignies, Guillaume; Cortes, Patricia; Aggarwal, Aneel K.; Blackledge, Martin; Gueroui, Zoher; Belle, Valerie; Stark, Jeremy M.; Modesti, Mauro; Ferrage, Fabien 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic CancerYu, Xufen; Li, Dongxu; Kottur, Jithesh; Kim, Huen Suk; Herring, Laura E.; Yu, Yao; Xie, Ling; Hu, Xiaoping; Chen, Xian; Cai, Ling; Liu, Jing; Aggarwal, Aneel K.; Wang, Gang Greg; Jin, Jian 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeuticLi, Dongxu; Yu, Xufen; Kottur, Jithesh; Gong, Weida; Zhang, Zhao; Storey, Aaron J.; Tsai, Yi-Hsuan; Uryu, Hidetaka; Shen, Yudao; Byrum, Stephanie D.; Edmondson, Rick D.; Mackintosh, Samuel G.; Cai, Ling; Liu, Zhijie; Aggarwal, Aneel K.; Tackett, Alan J.; Liu, Jing; Jin, Jian; Wang, Gang Greg 分享 收藏 分享 收藏 A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse modelsYu, Xufen; Li, Dongxu; Kottur, Jithesh; Shen, Yudao; Kim, Huen Suk; Park, Kwang-Su; Tsai, Yi-Hsuan; Gong, Weida; Wang, Jun; Suzuki, Kyogo; Parker, Joel; Herring, Laura; Kaniskan, H. Umit; Cai, Ling; Jain, Rinku; Liu, Jing; Aggarwal, Aneel K.; Wang, Gang Greg; Jin, Jian 分享 收藏 Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant diseaseSato, Katsutoshi; Padgaonkar, Amol A.; Baker, Stacey J.; Cosenza, Stephen C.; Rechkoblit, Olga; Venkata Subbaiah, D. R. C.; Domingo-Domenech, Josep; Bartkowski, Alison; Port, Elisa R.; Aggarwal, Aneel K.; Ramana Reddy, M. V.; Irie, Hanna Y.; Premkumar Reddy, E. 分享 收藏 FANCI functions as a repair/apoptosis switch in response to DNA crosslinksShah, Richa B.; Kernan, Jennifer L.; van Hoogstraten, Anya; Ando, Kiyohiro; Li, Yuanyuan; Belcher, Alicia L.; Mininger, Ivy; Bussenault, Andrei M.; Raman, Renuka; Ramanagoudr-Bhojappa, Ramanagouda; Huang, Tony T.; D'Andrea, Alan D.; Chandrasekharappa, Settara C.; Aggarwal, Aneel K.; Thompson, Ruth; Sidi, Samuel 分享 收藏 分享 收藏 分享 收藏 A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding AgentBaker, Stacey J.; Cosenza, Stephen C.; Athuluri-Divakar, Saikrishna; Reddy, M. V. Ramana; Vasquez-Del Carpio, Rodrigo; Jain, Rinku; Aggarwal, Aneel K.; Reddy, E. Premkumar 分享 收藏 Role of Nuclear Receptor Condensates in Ligand Induced Co-operative Gene RegulationNair, Sreejith; Yang, Lu; Meluzzi, Dario; Yang, Feng; Oh, Soohwan; Tan, Yuliang; Gamliel, Amir; Alshareedah, Ibraheem; Wang, Susan; Suter, Tom; Friedman, Meyer; Ma, Qi; Jayani, Ranveer; Zhang, Jie; Aggarwal, Aneel; Banerjee, Priya; Rosenfeld, Michael 分享 收藏 
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