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Paul J. Coleman

merck & company

66H指数
363论文数
1.4W被引数
收录论文 45
发表时间
2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
err2024-05-24
err1
PREAI
errBreslin, Michael J.; Schubert, Jeffrey W.; Wang, Deping; Huang, Chienjung; Clements, Michelle K.; Li, Yuxing; Zhou, Xiaoping; Vardigan, Joshua D.; Kraus, Richard L.; Santarelli, Vincent P.; Uslaner, Jason M.; Coleman, Paul J.; Stachel, Shawn J.
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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
err2023-01-10
err14
errOAAI
errLayton, Mark E.; Kern, Jeffrey C.; Hartingh, Timothy J.; Shipe, William D.; Raheem, Izzat; Kandebo, Monika; Hayes, Robert P.; Huszar, Sarah; Eddins, Donnie; Ma, Bennett; Fuerst, Joy; Wollenberg, Gordon K.; Li, Jing; Fritzen, Jeff; McGaughey, Georgia B.; Uslaner, Jason M.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D.
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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
err2021-03-07
err18
errOAAI
errBeshore, Douglas C.; Adam, Gregory C.; Barnard, Richard J. O.; Burlein, Christine; Gallicchio, Steven N.; Holloway, M. Katharine; Krosky, Daniel; Lemaire, Wei; Myers, Robert W.; Patel, Sangita; Plotkin, Michael A.; Powell, David A.; Rada, Vanessa; Cox, Christopher D.; Coleman, Paul J.; Klein, Daniel J.; Wolkenberg, Scott E.
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The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia
err2017-01-06
err100
PREAI
errColeman, Paul J.; Gotter, Anthony L.; Herring, W. Joseph; Winrow, Christopher J.; Renger, John J.
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
err2016-06-03
err70
errOAAI
errGotter, Anthony L.; Forman, Mark S.; Harrell, Charles M.; Stevens, Joanne; Svetnik, Vladimir; Yee, Ka Lai; Li, Xiaodong; Roecker, Anthony J.; Fox, Steven V.; Tannenbaum, Pamela L.; Garson, Susan L.; De Lepeleire, Inge; Calder, Nicole; Rosen, Laura; Struyk, Arie; Coleman, Paul J.; Herring, W. Joseph; Renger, John J.; Winrow, Christopher J.
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Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles
err2016-05-26
err214
errOAAI
errHostetler, Eric D.; Walji, Abbas M.; Zeng, Zhizhen; Miller, Patricia; Bennacef, Idriss; Salinas, Cristian; Connolly, Brett; Gantert, Liza; Haley, Hyking; Holahan, Marie; Purcell, Mona; Riffel, Kerry; Lohith, Talakad G.; Coleman, Paul; Soriano, Aileen; Ogawa, Aimie; Xu, Serena; Zhang, Xiaoping; Joshi, Elizabeth; Della Rocca, Joseph; Hesk, David; Schenk, David J.; Evelhoch, Jeffrey L.
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Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F}-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
err2016-05-05
err141
PREAI
errWalji, Abbas M.; Hostetler, Eric D.; Selnick, Harold; Zeng, Zhizhen; Miller, Patricia; Bennacef, Idriss; Salinas, Cristian; Connolly, Brett; Gantert, Liza; Holahan, Marie; O'Malley, Stacey; Purcell, Mona; Riffel, Kerry; Li, Jin; Balsells, Jaume; OBrien, Julie A.; Melquist, Stacey; Soriano, Aileen; Zhang, Xiaoping; Ogawa, Aimie; Xu, Serena; Joshi, Elizabeth; Della Rocca, Joseph; Hess, Fred J.; Schachter, Joel; Hesk, David; Schenk, David; Struyk, Arie; Babaoglu, Kerim; Lohith, Talakad G.; Wang, Yaode; Yang, Kun; Fu, Jianmin; Evelhoch, Jeffrey L.; Coleman, Paul J.
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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
err2016-03-07
err117
PREAI
errYin, Jie; Babaoglu, Kerim; Brautigam, Chad A.; Clark, Lindsay; Shao, Zhenhua; Scheuermann, Thomas H.; Harrell, Charles M.; Gotter, Anthony L.; Roecker, Anthony J.; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.; Rosenbaum, Daniel M.
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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
errSLEEP
IF4.9
err2016-03-01
err40
errOAAI
errTannenbaum, Pamela L.; Tye, Spencer J.; Stevens, Joanne; Gotter, Anthony L.; Fox, Steven V.; Savitz, Alan T.; Coleman, Paul J.; Uslaner, Jason M.; Kuduk, Scott D.; Hargreaves, Richard; Winrow, Christopher J.; Renger, John J.
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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors (vol 58, pg 8154, 2015)
err2015-12-28
err1
errOAAI
errRaheem, Izzat T.; Walji, Abbas M.; Klein, Daniel; Sanders, John M.; Powell, David A.; Abeywickrema, Pravien; Barbe, Guillaume; Bennet, Amrith; Childers, Karla; Christensen, Melodie; Clas, Sophie-Dorothee; Dubost, David; Embrey, Mark; Grobler, Jay; Hafey, Michael J.; Hartingh, Timothy J.; Hazuda, Daria J.; Kuethe, Jeffrey T.; Dunn, Jamie McCabe; Miller, Michael D.; Moore, Keith P.; Nolting, Andrew; Pajkovic, Natasa; Patel, Sangita; Peng, Zuihui; Rada, Vanessa; Rearden, Paul; Schreier, John D.; Sisko, John; Steele, Thomas G.; Truchon, Jean-Francois; Wai, John; Xu, Min; Coleman, Paul J.
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Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193
err2015-11-23
err9
PREAI
errHostetler, Eric D.; Fan, Hong; Joshi, Aniket D.; Zeng, Zhizhen; Eng, Waisi; Gantert, Liza; Holahan, Marie; Meng, Xianjun; Miller, Patricia; O'Malley, Stacey; Purcell, Mona; Riffel, Kerry; Salinas, Cristian; Williams, Mangay; Ma, Bennett; Buist, Nicole; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D.; Flores, Brock A.; Raheem, Izzat T.; Cook, Jacquelynn J.; Evelhoch, Jeffrey L.
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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors
err2015-10-08
err36
PREAI
errRaheem, Izzat T.; Walji, Abbas M.; Klein, Daniel; Sanders, John M.; Powell, David A.; Abeywickrema, Pravien; Barbe, Guillaume; Bennet, Amrith; Clas, Sophie-Dorothee; Dubost, David; Embrey, Mark; Grobler, Jay; Hafey, Michael J.; Hartingh, Timothy J.; Hazuda, Dania J.; Miller, Michael D.; Moore, Keith P.; Pajkovic, Natasa; Patel, Sangita; Rada, Vanessa; Rearden, Paul; Schreier, John D.; Sisko, John; Steele, Thomas G.; Truchon, Jean-Francois; Wai, John; Xu, Min; Coleman, Paul J.
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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis
err2015-09-25
err52
PREAI
errShipe, William D.; Sharik, Steven S.; Barrow, James C.; McGaughey, Georgia B.; Theberge, Cory R.; Uslaner, Jason M.; Yan, Youwei; Renger, John J.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D.
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Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia
err2015-09-15
err101
PREAI
errRoecker, Anthony J.; Cox, Christopher D.; Colemant, Paul J.
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P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
err2015-03-10
err21
PREAI
errRudd, Michael T.; Butcher, John W.; Nguyen, Kevin T.; McIntyre, Charles J.; Romano, Joseph J.; Gilbert, Kevin F.; Bush, Kimberly J.; Liverton, Nigel J.; Holloway, M. Katharine; Harper, Steven; Ferrara, Marco; DiFilippo, Marcello; Summa, Vincenzo; Swestock, John; Fritzen, Jeff; Carroll, Steven S.; Burlein, Christine; DiMuzio, Jillian M.; Gates, Adam; Graham, Donald J.; Huang, Qian; McClain, Stephanie; McHale, Carolyn; Stahlhut, Mark W.; Black, Stuart; Chase, Robert; Soriano, Aileen; Fandozzi, Christine M.; Taylor, Anne; Trainor, Nicole; Olsen, David B.; Coleman, Paul J.; Ludmerer, Steven W.; McCauley, John A.
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Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption
err2014-12-02
err25
PREAI
errWalji, Abbas M.; Sanchez, Rosa I.; Clas, Sophie-Dorothee; Nofsinger, Rebecca; Ruiz, Manuel de Lera; Li, Jing; Bennet, Amrithraj; John, Christopher; Bennett, David Jonathan; Sanders, John M.; Di Marco, Christina N.; Kim, Somang Hope; Balsells, Jaume; Ceglia, Scott S.; Dang, Qun; Manser, Kimberly; Nissley, Becky; Wai, John S.; Hafey, Michael; Wang, Junying; Chessen, Gene; Templeton, Allen; Higgins, John; Smith, Ronald; Wu, Yunhui; Grobler, Jay; Coleman, Paul J.
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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants (vol 56, pg 4161, 2012)
err2014-08-01
err2
errOAAI
errSumma, Vincenzo; Ludmerer, Steven W.; McCauley, John A.; Fandozzi, Christine; Burlein, Christine; Claudio, Giuliano; Coleman, Paul J.; DiMuzio, Jillian M.; Ferrara, Marco; Di Filippo, Marcello; Gates, Adam T.; Graham, Donald J.; Harper, Steven; Hazuda, Daria J.; Huang, Qian; McHale, Carolyn; Monteagudo, Edith; Pucci, Vincenzo; Rowley, Michael; Rudd, Michael T.; Soriano, Aileen; Stahlhut, Mark W.; Vacca, Joseph P.; Olsen, David B.; Liverton, Nigel J.; Carroll, Steven S.
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Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs
err2014-02-01
err18
errOAAI
errMcGaughey, Georgia; Bayly, Christopher I.; Cox, Christopher D.; Schreier, John D.; Breslin, Michael J.; Bogusky, Michael; Pitzenberger, Steve; Ball, Richard; Coleman, Paul J.
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Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors
err2014-01-09
err26
errOAAI
errShah, Unmesh; Jayne, Charles; Chackalamannil, Samuel; Velazquez, Francisco; Guo, Zhuyan; Buevich, Alexei; Howe, John A.; Chase, Robert; Soriano, Aileen; Agrawal, Sony; Rudd, Michael T.; McCauley, John A.; Liverton, Nigel J.; Romano, Joseph; Bush, Kimberly; Coleman, Paul J.; Grise-Bard, Christiane; Brochu, Marie-Christine; Charron, Sylvie; Aulakh, Virender; Bachand, Benoit; Beaulieu, Patrick; Zaghdane, Helmi; Bhat, Sathesh; Han, Yongxin; Vacca, Joseph P.; Davies, Ian W.; Weber, Ann E.; Venkatraman, Srikanth
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Discovery of 5-Chloro-N-[( 5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia
err2013-12-27
err78
PREAI
errRoecker, Anthony J.; Mercer, Swati P.; Schreier, John D.; Cox, Christopher D.; Fraley, Mark E.; Steen, Justin T.; Lemaire, Wei; Bruno, Joseph G.; Harrell, C. Meacham; Garson, Susan L.; Gotter, Anthony L.; Fox, Steven V.; Stevens, Joanne; Tannenbaum, Pamela L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Stellabott, Joyce; Hartman, George D.; Young, Steven D.; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
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