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Discovery and characterization of Casdatifan (AB521), a clinical-stage, potent, and selective Hypoxia-Inducible Factor (HIF)-2α inhibitor Lawson, Kenneth V.; Mailyan, Artur; Mata, Guillaume; Beatty, Joel W.; Drew, Samuel L.; Fournier, Jeremy T. A.; Kalisiak, Jaroslaw; Tran, Ahn T.; Yu, Kai; Rosen, Brandon R.; Hardman, Clayton; Epplin, Matthew; Sivick, Kelsey E.; Piovesan, Dana; Liu, Suan; Ginn, Elain; Meleza, Cesar A.; Seitz, Lisa; Cheng, Tzuling; Pham, Amber; Ghasemi, Mohammad; Foster, Paul G.; Walters, Matthew J.; Leleti, Manmohan; Powers, Jay P. 分享 收藏
Quemliclustat (CD73 Inhibitor) reduces adenosine-regulated NR4A gene expression and increases mPDAC inflammation in patients from the ARC-8 trial Kim, Ji Yun; Wang, Ning; Weeder, Ben; Stagnaro, Enzo; Mrouj, Karim; Aquino, Jose; He, Xian; O'Reilly, Eileen M.; Pant, Shubham; Manji, Gulam A.; Wainberg, Zev A.; Rhee, Joon; Beagle, Brandon; DiRenzo, Daniel; Walters, Matthew J.; Kaplan, Angelo; Cho, Sean; Kabbarah, Omar 分享 收藏
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Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors Anderson, Amy E.; Parashar, Kaustubh; Jin, Ke; Clor, Julie; Stagnaro, Carlo E.; Vani, Urvi; Singh, Jaskirat; Chen, Ada; Guan, Yihong; Talukdar, Priyanka; Sathishkumar, Pavithra; Juat, Damie J.; Singh, Hema; Kushwaha, Ritu; Zhao, Xiaoning; Kaplan, Angelo; Seitz, Lisa; Walters, Matthew J.; Fernandez-Salas, Ester; Walker, Nigel P. C.; Bowman, Christine E. 分享 收藏
Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells Piovesan, Dana; de Groot, Amber E.; Cho, Soonweng; Anderson, Amy E.; Ray, Rebecca D.; Patnaik, Amita; Foster, Paul G.; Mitchell, Casey G.; Lopez Espinoza, Alejandra Y.; Zhu, Wandi S.; Stagnaro, Carlo E.; Singh, Hema; Zhao, Xiaoning; Seitz, Lisa; Walker, Nigel P.; Walters, Matthew J.; Sivick, Kelsey E. 分享 收藏
Cbl inhibition increases the response of cytotoxic T cells to sub-optimal stimulation and drives enhanced anti-tumor responses alone or in combination with PD-1 blockade Yamashiro, Livia; Marubayashi, Sachie; Rayaji, Rameshwari; Battsooj, Anudari; Mrouj, Karim; Singh, Hema; Lee, Yue Tong; Chen, Ada; Shen, Lunda; Mailyan, Artur; Yu, Kai; Podunavac, Masha; Yu, Julie; Liu, Dongdong; Hardman, Clayton; Yin, Johnny; Gangam, Srikanth; Lawson, Ken; Leleti, Manmohan; Walters, Matthew; DiRenzo, Daniel 分享 收藏
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Targeting hypoxia inducible factor (HIF)-2α with AB521, a novel and potent small molecule HIF-2α inhibitor, for the treatment of clear cell renal cell carcinoma Piovesan, Dana; Cho, Soonweng; Lawson, Kenneth V.; Liao, Kai H.; Foster, Paul G.; Cheng, Tzuling; Walters, Matthew J.; Gauthier, Kelsey E. Sivick 分享 收藏
Characterization of AB598, a therapeutic anti-human CD39 antibody for the treatment of cancer Anderson, Amy E.; Kaplan, Angelo; Vani, Urvi; Stagnaro, Enzo; Parashar, Kaustubh; Clor, Julie; Walker, Nigel P.; Young, Steve W.; Walters, Matthew J.; Fernandez-Salas, Ester; Bowman, Christine E.; Seitz, Lisa 分享 收藏
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Anti-TIGIT antibodies promote immune activation relevant to targeting stem-like and tumor-specific T cells in combination with anti-PD-1 Gauthier, Kelsey E. Sivick; Piovesan, Dana; de Groot, Amber E.; Reiner, Gabrielle L.; Schweickert, Patrick G.; Soriano, Ferdie; Chen, Ada; Singh, Hema; Zhao, Xiaoning; Seitz, Lisa; Reddy, Anita; Young, Stephen W.; Walker, Nigel; Walters, Matthew J. 分享 收藏
Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity Piovesan, Dana; Tan, Joanne B. L.; Becker, Annette; Banuelos, Jesus; Narasappa, Nell; DiRenzo, Daniel; Zhang, Kristen; Chen, Ada; Ginn, Elaine; Udyavar, Akshata R.; Yin, Fangfang; Paprcka, Susan L.; Purandare, Bhamini; Park, Timothy W.; Kimura, Nikki; Kalisiak, Jaroslaw; Young, Stephen W.; Powers, Jay P.; Schindler, Uli; Sivick, Kelsey E.; Walters, Matthew J. 分享 收藏
AB521 potently and selectively inhibits pro-tumorigenic gene transcription by Hypoxia-Inducible Factor (HIF)-2a in vitro and in vivo Gauthier, Kelsey E. Sivick; Piovesan, Dana; Cho, Soonweng; Lawson, Kenneth V.; Schweickert, Patrick G.; Lopez, Alejandra; Liu, Suan; Park, Timothy; Mailyan, Artur; Fournier, Jeremy T. A.; Beatty, Joel W.; Drew, Samuel L.; Kalisiak, Jarek; Gal, Balint; Mata, Guillaume; Wang, Zhang; Rosen, Brandon R.; Hardman, Clayton; Epplin, Matthaw P.; Yu, Kai; Haelsig, Karl T.; Jin, Lixia; Ginn, Elaine; Au, Jennie; Meleza, Cesar A.; Tencer, Joel; Pham, Amber; Kwon, Hyock J.; Young, Stephen W.; Leleti, Manmohan; Powers, Jay P.; Walters, Matthew J. 分享 收藏
Potent and selective AXL tyrosine kinase inhibition demonstrates significant anti-tumor efficacy in combination with standard of care therapeutics in preclinical models Paprcka, Susan L.; Sridhar, Subhasree; Luu, Irene M.; Jafri, Salema; Miles, Dillon H.; Liu, Suan; Flores, Ruben; Qu, Shiwei; Lamani, Manjunath; Paladugu, Sriivas; Meleza, Cesar; Wu, James; Singh, Hema; Chen, Yu; Cho, Sean; Udyavar, Akshata; Kaplan, Angelo; Stargnaro, Enzo; Zhao, Xiaoning; Jin, Lixia; Leleti, Manmohan R.; Young, Stephen W.; Powers, Jay P.; Walters, Matthew J.; Fernandez-Salas, Ester 分享 收藏
Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ) Mata, Guillaume; Miles, Dillon H.; Drew, Samuel L.; Fournier, Jeremy; Lawson, Kenneth, V; Mailyan, Artur K.; Sharif, Ehesan U.; Yan, Xuelei; Beatty, Joel W.; Banuelos, Jesus; Chen, Jie; Ginn, Elaine; Chen, Ada; Gerrick, Kimberline Y.; Pham, Amber T.; Wong, Kent; Soni, Divyank; Dhanota, Puja; Shaqfeh, Stefan G.; Meleza, Cesar; Narasappa, Nell; Singh, Hema; Zhao, Xiaoning; Jin, Lixia; Schindler, Ulrike; Walters, Matthew J.; Young, Stephen W.; Walker, Nigel P.; Leleti, Manmohan Reddy; Powers, Jay P.; Jeffrey, Jenna L. 分享 收藏
NOVEL, POTENT, AND SELECTIVE INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF)-2α REVERSE PRO-TUMORIGENIC TRANSCRIPTIONAL PROGRAMMING IN CANCER, STROMAL, AND IMMUNE CELLS Gauthier, Kelsey Sivick; Piovesan, Dana; Lawson, Kenneth; Cho, Soonweng; Udyavar, Akshata; Chan, Jean; Chen, Ada; Au, Jennie; Meleza, Cesar; Zhao, Xiaoning; Anh Tran; Drew, Samuel; Gal, Balint; Rosen, Brandon; Leleti, Manmohan; Ginn, Elaine; Jin, Lixia; Young, Stephen; Powers, Jay; Walters, Matthew 分享 收藏
Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors 发现有效和选择性的7-氮杂吲哚异吲哚啉酮基pi3k γ 抑制剂 Miles, Dillon H.; Yan, Xuelei; Thomas-Tran, Rhiannon; Fournier, Jeremy; Sharif, Ehesan U.; Drew, Samuel L.; Mata, Guillaume; Lawson, Kenneth, V; Ginn, Elaine; Wong, Kent; Soni, Divyank; Dhanota, Puja; Shaqfeh, Stefan G.; Meleza, Cesar; Chen, Ada; Pham, Amber T.; Park, Timothy; Swinarski, Debbie; Banuelos, Jesus; Schindler, Ulrike; Walters, Matthew J.; Walker, Nigel P.; Zhao, Xiaoning; Young, Stephen W.; Chen, Jie; Jin, Lixia; Leleti, Manmohan Reddy; Powers, Jay P.; Jeffrey, Jenna L. 分享 收藏
Discovery of Potent and Selective PI3Kγ Inhibitors Drew, Samuel L.; Thomas-Tran, Rhiannon; Beatty, Joel W.; Fournier, Jeremy; Lawson, Kenneth, V; Miles, Dillon H.; Mata, Guillaume; Sharif, Ehesan U.; Yan, Xuelei; Mailyan, Artur K.; Ginn, Elaine; Chen, Jie; Wong, Kent; Soni, Divyank; Dhanota, Puja; Chen, Pei-Yu; Shaqfeh, Stefan G.; Meleza, Cesar; Pham, Amber T.; Chen, Ada; Zhao, Xiaoning; Banuelos, Jesus; Jin, Lixia; Schindler, Ulrike; Walters, Matthew J.; Young, Stephen W.; Walker, Nigel P.; Leleti, Manmohan Reddy; Powers, Jay P.; Jeffrey, Jenna L. 分享 收藏
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