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AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models AAV9介导的MYBPC3基因治疗通过优化表达盒增强MYBPC3心肌病模型的心脏功能和生存率 Greer-Short, Amara; Greenwood, Anna; Leon, Elena C.; Qureshi, Tawny Neal; von Kraut, Konor; Wong, Justin; Tsui, Jonathan H.; Reid, Christopher A.; Cheng, Ze; Easter, Emilee; Yang, Jin; Ho, Jaclyn; Steltzer, Stephanie; Budan, Ana; Cho, Marie; Chandrakumar, Rishikesan; Cisne-Thompson, Olga; Feathers, Charles; Chung, Tae Won; Rodriguez, Neshel; Jones, Samantha; Alleyne-Levy, Chris; Liu, Jun; Jing, Frank; Prince, William S.; Lin, Jianmin; Ivey, Kathryn N.; Tingley, Whittemore G.; Hoey, Timothy; Lombardi, Laura M. 分享 收藏
Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice (vol 15, 1352, 2024) Ranjbarvaziri, Sara; Zeng, Aliya; Wu, Iris; Greer-Short, Amara; Farshidfar, Farshad; Budan, Ana; Xu, Emma; Shenwai, Reva; Kozubov, Matthew; Li, Cindy; Van Pell, Melissa; Grafton, Francis; Mackay, Charles E.; Song, Xiaomei; Priest, James R.; Argast, Gretchen; Mandegar, Mohammad A.; Hoey, Timothy; Yang, Jin 分享 收藏
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as an In Vitro Model to Evaluate the Efficacy of a Gene Replacement Therapy for Plakophilin-2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy Gil, Isaac Perea; Aycinena, J. Alex; Chandrakumar, Rishikesan; Cisne-Thompson, Olga; Tsui, Jonathan; Zepeda, Bernardo; Tefera, Anley; Shenwai, Reva; Farshidfar, Farshad; Jones, Chayse; Yang, Zhihong Jane; Hoey, Timothy; Argast, Gretchen 分享 收藏
AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy Wu, Iris; Zeng, Aliya; Greer-Short, Amara; Aycinena, J. Alex; Tefera, Anley E.; Shenwai, Reva; Farshidfar, Farshad; Van Pell, Melissa; Xu, Emma; Reid, Chris; Rodriguez, Neshel; Lim, Beatriz; Chung, Tae Won; Woods, Joseph; Scott, Aquilla; Jones, Samantha; Dee-Hoskins, Cristina; Gutierrez, Carolina G.; Madariaga, Jessie; Robinson, Kevin; Hatter, Yolanda; Butler, Renee; Steltzer, Stephanie; Ho, Jaclyn; Priest, James R.; Song, Xiaomei; Jing, Frank; Green, Kristina; Ivey, Kathryn N.; Hoey, Timothy; Yang, Jin; Yang, Zhihong Jane 分享 收藏
Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice 靶向HDAC6治疗射血分数保留的小鼠心力衰竭 Ranjbarvaziri, Sara; Zeng, Aliya; Wu, Iris; Greer-Short, Amara; Farshidfar, Farshad; Budan, Ana; Xu, Emma; Shenwai, Reva; Kozubov, Matthew; Li, Cindy; Van Pell, Melissa; Grafton, Francis; MacKay, Charles E.; Song, Xiaomei; Priest, James R.; Argast, Gretchen; Mandegar, Mohammad A.; Hoey, Timothy; Yang, Jin 分享 收藏
Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus Zhou, Huanyu; Yang, Jin; Srinath, Chetan; Zeng, Aliya; Wu, Iris; Leon, Elena C.; Qureshi, Tawny Neal; Reid, Christopher A.; Nettesheim, Emily R.; Xu, Emma; Duclos, Zoe; Mohamed, Tamer M. A.; Farshidfar, Farshad; Fejes, Anthony; Liu, Jun; Jones, Samantha; Feathers, Charles; Chung, Tae Won; Jing, Frank; Prince, William S.; Lin, Jianmin; Yu, Pengzhi; Srivastava, Deepak; Hoey, Timothy; Ivey, Kathryn N.; Lombardi, Laura M. 分享 收藏
Histone Deacetylase 6 (HDAC6) Inhibitor Improves StressInduced Cardiomyocyte Restructuring in Heart Failure with Preserved Ejection Fraction (HFpEF) in a Multimodal Manner Based on Single Nucleus RNA-seq (snRNA-seq) Farshidfar, Farshad; Kozubov, Matthew; Shenwai, Reva; Hosseinian, Amir; Yang, Jin; Zeng, Aliya; Wu, Iris; Greer-Short, Amara; Mackay, Charles; Priest, James; Hoey, Timothy 分享 收藏
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Clinical Development of Cardiac Reprogramming Gene Therapy Zhou, Huanyu; Lombardi, Laura M.; Reid, Christopher A.; Yang, Jin; Srinath, Chetan; Zeng, Aliya; Leon, Elena C.; Qureshi, Tawny N.; Nettesheim, Emily R.; Xu, Emma; Duclos, Zoe; Liu, Jun; Jones, Samantha; Feathers, Charles; Chung, Tae Won; Jing, Frank; Prince, William; Lin, JianMin; Hoey, Timothy; Ivey, Kathryn 分享 收藏
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COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins Lim, Gah-Hyun; Hoey, Timothy; Zhu, Shifeng; Clavel, Marion; Yu, Keshun; Navarre, Duroy; Kachroo, Aardra; Deragon, Jean-Marc; Kachroo, Pradeep 分享 收藏
RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations Fischer, Marcus M.; Yeung, V. Pete; Cattaruzza, Fiore; Hussein, Rajaa; Yen, Wan-Ching; Murriel, Christopher; Evans, James W.; O'Young, Gilbert; Brunner, Alayne L.; Wang, Min; Cain, Jennifer; Cancilla, Belinda; Kapoun, Ann; Hoey, Timothy 分享 收藏
R-SPONDIN3 antagonism sensitizes colorectal cancer to taxane treatment Fischer, Marcus M.; Yeung, V. Pete; Cattaruzza, Fiore; Murriel, Christopher; Evans, James W.; O'Young, Gilbert; Brunner, Alayne; Wang, Min; Cancilla, Belinda; Kapoun, Ann; Hoey, Timothy 分享 收藏
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Fischer, Marcus M.; Cancilla, Belinda; Yeung, V. Pete; Cattaruzza, Fiore; Chartier, Cecile; Murriel, Christopher L.; Cain, Jennifer; Tam, Raymond; Cheng, Chieh-Yang; Evans, James W.; O'Young, Gilbert; Song, Xiaomei; Lewicki, John; Kapoun, Ann M.; Gurney, Austin; Yen, Wan-Ching; Hoey, Timothy 分享 收藏
N Development of a 6-gene qPCR RUO-validated assay as a predictive biomarker for response of vantictumab (OMP-18R5; anti-frizzled) in HER2-breast cancer patients Zhang, C.; O'Young, G.; Wikstrom, K.; Davison, T.; Yeung, P.; Cattaruzza, F.; Yen, W-C; Hoey, T.; Lewicki, J.; Rachmann, R.; Kerr, P.; Hill, L.; Eason, R.; McErlean, S.; Liu, Y.; Kapoun, A. M. 分享 收藏
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Chartier, Cecile; Raval, Janak; Axelrod, Fumiko; Bond, Chris; Cain, Jennifer; Dee-Hoskins, Cristina; Ma, Shirley; Fischer, Marcus M.; Shah, Jalpa; Wei, Jie; Ji, May; Lam, Andrew; Stroud, Michelle; Yen, Wan-Ching; Yeung, Pete; Cancilla, Belinda; O'Young, Gilbert; Wang, Min; Kapoun, Ann M.; Lewicki, John; Hoey, Timothy; Gurney, Austin 分享 收藏
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Tarextumab (Anti-NOTCH2/3) reverses NOTCH2 and NOTCH3-dependent tumorigenicity and metastases in small cell lung cancer Shah, Jalpa; O'Young, Gilbert; Wei, Jie; Fischer, Marcus; Yen, Wan-Ching; Cancilla, Belinda; Kapoun, Ann; Lewicki, John; Cain, Jennifer; Hoey, Timothy 分享 收藏
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